Cardio CRP or CCRP

[Guest guest]

Has anyone had high numbers with CCRP or Cardio CRP - this just came

up for me ... I got bloodwork to determine what was going on with

increased pain and severe fatigue I wrote about last week.... blood

tests showed high lymphocytes ... I think due to my first prolonged

cholangitis attack ... this is what I found on the web about CCRP,

but interested to know if anyone else had this show up ... and if

so, what you did about it? the info does reference

infection/inflamation...but this is about the heart I think...

I also have very itchy eyes for past several weeks- and now while on

Cipro having more itching..any help is appreciated. Thanks

barbara in MD

Cardio CRP™

Test Summary

Clinical Use

Assess relative risk of cardiovascular disease (CVD)

Assess risk of a recurrent cardiovascular event in patients with

coronary heart disease (CHD)

Clinical Background

C-reactive protein (CRP) is a non-specific acute-phase protein

produced by the liver in response to tissue injury, infection, and

inflammation. Measurement of serum levels, which rise as much as

1,000-fold after an acute event, has traditionally been used to

diagnose and monitor acute inflammatory states. However, mild CRP

elevation (within the normal, non-acute-phase range) has recently

emerged as a valuable marker of cardiovascular risk.1

Mildly elevated CRP (eg, £10 mg/L) has been linked with risk for

CVD, including first and recurrent coronary events1 and stroke;2

vascular events after stroke;3 myocardial infarction or angina in

patients with peripheral vascular disease;4 poor outcome in acute

coronary syndromes1,5 and congestive heart failure;6 restenosis

after coronary angioplasty;7 sudden cardiac death;8 hypertension;9

dementia;10 and type 2 diabetes mellitus.11 Prospective studies with

highly sensitive assays such as Cardio CRP have consistently shown

CRP to be a strong predictor of increased cardiovascular risk in

both men and women.1 The predictive value of CRP is independent of

other established risk factors, including LDL-cholesterol, and

screening with both CRP and LDL may provide a better risk assessment

than using either test alone.12 Additionally, evidence suggests

patients with high CRP/normal LDL are at greater risk than those

with normal CRP/high LDL.12

Many therapies aimed at reducing cardiovascular risk act through

anti-inflammatory pathways. Aspirin and statins both yield the

greatest preventive effect in patients with the highest CRP

levels.1,13 Statin therapy reduces the risk of first acute coronary

events14 and stroke15 associated with elevated CRP, and recent

evidence suggests patients who have low CRP levels after statin

therapy have better clinical outcomes regardless of the resultant

LDL level.16 Statin therapy also appears to reduce the risk of major

adverse cardiac events after stent implantation in patients with

elevated CRP levels.17 Furthermore, evidence from multiple studies

indicate that intensive statin therapy leads to an early reduction

in cardiac events, sustained for over 2 years, in patients with

acute coronary syndrome.18 Such reduction is likely related to

diminished inflammation as evidenced by greater decreases in CRP

levels observed after statin therapy than observed after placebo.19

Weight loss20 and regular physical activity,21 both associated with

reduced cardiovascular risk, appear to have anti-inflammatory

effects as well (ie, reduced CRP, fibrinogen, and white blood cell

levels).

Individuals Suitable For Testing

Individuals without a previous history of CHD, especially those with

intermediate CHD risk (10-year risk = 10% to 20% according to

Framingham global risk scoring system1,22)

Patients with stable or acute coronary disease

Specimen Requirements

1 mL room temperature serum (0.5 mL minimum); refrigerated or frozen

serum also acceptable. Alternatively, heparin or EDTA plasma may be

submitted.

Overnight fasting prior to specimen collection is preferred to avoid

excess turbidity due to lipemia. Samples should be collected 2 or

more weeks after resolution of any acute inflammatory disease.

Method

Nephelometric method utilizing latex particles coated with CRP

monoclonal antibodies

Standardized against the International Federation of Clinical

Chemistry and Laboratory Medicine (IFCC)/ Bureau Communautaire de

Référence (BCR)/College of American Pathologists (CAP) CRP reference

preparation

Analytical sensitivity: 0.2 mg/L

Cardio CRP results are reported in mg/L with an interpretive comment

regarding the risk for CHD

Synonyms: high-sensitivity C-reactive protein; highly sensitive C-

reactive protein

CPT Code*: 86141

Reference Range1

Cardio CRP mg/L Relative Cardiovascular Risk

<1.0 Low

1.0–3.0 Average

3.1–10.0 High

>10.0 Persistent elevations may represent non-cardiovascular

inflammation

Interpretive Information

Ideally, CRP levels should be measured twice, 2 weeks apart, and the

average of the 2 values used for risk assessment.

The reference ranges listed above are derived from a study of more

than 40,000 adults from various populations.1 CRP values in the

range of 3.1 to 10 mg/L indicate an approximate 2.0 relative risk of

CVD compared with those in the lowest tertile. Levels persistently

above 10 mg/L may indicate an acute inflammatory process; sources of

infection or inflammation should be sought and the test repeated at

least 2 weeks later, after the inflammatory response has resolved.1

The following are associated with increased CRP levels: elevated

blood pressure, elevated body mass index, cigarette smoking,

metabolic syndrome, diabetes, low HDL levels, high triglyceride

levels, use of estrogen or progesterone, and chronic infections or

inflammation. Moderate alcohol intake, physical activity, weight

loss, and medications including statins, fibrates, and niacin are

associated with decreased levels.1

[Guest guest]

Noah has had elevated CRP several times (not CCRP) and his doctor has used that to measure when a flare might be coming or as a way to know when to watch his well-being more carefully overall.

She usually ups his blood testing to weekly when the CRP has gone up.

Just our experience with CRP not CCRP. Sorry I could not help more.

Mom of Zoe (13) My very normal (teenager normal) soccer player;

Noah (9) Indeterminate colitis, PSC, Osteopenia (1-4 lumbar vertebrae), Enthesopathy;

Aidan (5) Moderately-severe SNHL bilaterally

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[Guest guest]

Noah has had elevated CRP several times (not CCRP) and his doctor has used that to measure when a flare might be coming or as a way to know when to watch his well-being more carefully overall.

She usually ups his blood testing to weekly when the CRP has gone up.

Just our experience with CRP not CCRP. Sorry I could not help more.

Mom of Zoe (13) My very normal (teenager normal) soccer player;

Noah (9) Indeterminate colitis, PSC, Osteopenia (1-4 lumbar vertebrae), Enthesopathy;

Aidan (5) Moderately-severe SNHL bilaterally

Recycle Yourself

Become an Organ Donor