Wellbutrin, restoril and compazine can be a very bad combination of meds

July 3, 2006

I was rediagnosed with small duct PSC about 6 months ago. My blood test labs

are now all good, but I've been feeling severely fatigued. I was ready to

apply for permanent disability from work. I had my j-pouch surgery in Oct.

2005 with the takedown surgery last January, so I've been recovering from

surgery as well. I assumed the fatigue was from the PSC and the surgery. The

insomnia started about the time of the j-pouch surgery in Oct. I started

taking restoril for the insomnia about 6 or 7 months ago. The nausea started

about 2-3 years ago, and I've been on compazine for at least a year now. I

switched from Prozac to Wellbutrin within the last year due to grinding of

my teeth from the Prozac. I had wanted to try to go off the anti-depressant

but my doctor seemed unwilling to do that, and as it happened the last few

years have been difficult with my health issues, and dealing with a

difficult job, and elderly and ailing parents, including the death of my

father. So I've stayed on the anti-depressants. Now with the fatigue being

as bad as it's been, I've been very depressed from that.

Well, the hepatologist told me on Friday that the fatigue cannot be from the

liver, because my liver is doing well now. I'm still in early stage PSC. He

suggested that the cause of the fatigue is more likely the combination of

Wellbutrin and restoril, which are both very powerful brain

regulators/modulators. It turns out when I looked up wellbutrin, restoril

and compazine I was very shocked at the use of the drugs and the side

effects. I had read about them when I started taking them, but at the time

it didn't seem so bad or so scary, and not everyone suffers from the side

effects. The doctor told me that I needed to wean myself off these drugs, at

least the restoril & wellbutrin, which I just started doing, and I already

feel considerably better, despite the insomnia (the insomnia appears to be

caused by the wellbutrin). The fatigue has already lessened considerably.

I was wondering if others have suffered these side effects from this

combination of drugs. In addition I've developed muscle tension in my hands,

an almost constant strong bite of my right jaw, drooling, increased

sensitivity to light, and leaking of the j-pouch at night.

What amazes me is that with all of the doctors I've been seeing, no other

doctor brought this up until now. Perhaps I didn't complain as strongly as

this time about the fatigue, but I have definitely been complaining about

the fatigue, and have been on disability due to it. I pick up my meds at the

same pharmacy, and there was no red flag at the pharmacy either.

Thanks for any additional comments on this.

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