Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 Dear Dave, It's great to hear of the marked improvement in the health of Judy's dad. What a relief to know that liver failure was not the issue. I hope that things continue to improve for him. Ricky A sigh of relief Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 Dear Dave, It's great to hear of the marked improvement in the health of Judy's dad. What a relief to know that liver failure was not the issue. I hope that things continue to improve for him. Ricky A sigh of relief Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 Dear Dave, It's great to hear of the marked improvement in the health of Judy's dad. What a relief to know that liver failure was not the issue. I hope that things continue to improve for him. Ricky A sigh of relief Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 > Judy's father's lab results today looked much improved... and Judy - Excellent news! It is great to hear that your father's labs are better. Hopefully he feels the improvement already. I appreciate your updates; without hearing follow-up, I feel like someone " borrowed " your book and you don't know the next chapter! Best wishes to both of you and to your family! Joanne (, Ca; mom of 15 11/12ths; UC/PSC 2-06) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 > Judy's father's lab results today looked much improved... and Judy - Excellent news! It is great to hear that your father's labs are better. Hopefully he feels the improvement already. I appreciate your updates; without hearing follow-up, I feel like someone " borrowed " your book and you don't know the next chapter! Best wishes to both of you and to your family! Joanne (, Ca; mom of 15 11/12ths; UC/PSC 2-06) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 > Judy's father's lab results today looked much improved... and Judy - Excellent news! It is great to hear that your father's labs are better. Hopefully he feels the improvement already. I appreciate your updates; without hearing follow-up, I feel like someone " borrowed " your book and you don't know the next chapter! Best wishes to both of you and to your family! Joanne (, Ca; mom of 15 11/12ths; UC/PSC 2-06) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 Dear and Judy ,This is good news, I hope everything continues to improve.It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC.Bills eosinophils are still elevated. Lee Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 Dear and Judy ,This is good news, I hope everything continues to improve.It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC.Bills eosinophils are still elevated. Lee Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 Dear and Judy ,This is good news, I hope everything continues to improve.It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC.Bills eosinophils are still elevated. Lee Dear All; Judy's father's lab results today looked much improved with respect to liver function tests ... his albumin is up from 2.9 to 3.0, his ALT and AST are normal, his alkaline phosphatase is down from 419 to 298, and his bilirubin is down from 5.1 to 1.1. Also his serum sodium is back up from 129 to 140. This time they did a complete blood count, and his eosinophils were elevated ... a possible residual signature of allopurinol hypersensitivity [thanks to Lee's husband, , for suggesting this test!]. Although we cannot be certain that his liver problem was caused by allopurinol, it certainly looks as though everything is normalizing just be staying off this drug. The only way to tell whether this was the cause would be to start taking it again, but this does not seem to be worth the risk. Although Judy's father's kidney function tests remain poor, at least we can breathe a sigh of relief that liver failure is not in the cards. Thanks again to all who offered advice on what to do. Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 > It is strange how this " eosinophils " business keeps showing up and I just wonder what all the connection is with PSC. Bills eosinophils are still elevated. Dear Lee; The connection(s) between elevated eosinophils and PSC might be related to asthma and allergies, and may in part be genetically determined. For instance, there's a connection between interleukin- 10 gene variants and elevated eosinophils in asthma. Interleukin-10 is one of the candidate inflammatory bowel disease genes ... mice deficient in interleukin-10 develop colitis. Interleukin-10 may be required for the proper control of T cells to inhibit inflammatory diseases such as asthma and IBD. But there could be many interactions with other genes, pathogens, and other environmental factors. I wish I knew how all the puzzle pieces fit together! Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 > It is strange how this " eosinophils " business keeps showing up and I just wonder what all the connection is with PSC. Bills eosinophils are still elevated. Dear Lee; The connection(s) between elevated eosinophils and PSC might be related to asthma and allergies, and may in part be genetically determined. For instance, there's a connection between interleukin- 10 gene variants and elevated eosinophils in asthma. Interleukin-10 is one of the candidate inflammatory bowel disease genes ... mice deficient in interleukin-10 develop colitis. Interleukin-10 may be required for the proper control of T cells to inhibit inflammatory diseases such as asthma and IBD. But there could be many interactions with other genes, pathogens, and other environmental factors. I wish I knew how all the puzzle pieces fit together! Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 I also wish we knew how this puzzle went together. I have a hunch that the elevated eosinophils is important somehow.PSC seems so tied in to the allergies.As if the internal digestive system was inflamed from an allergic source.Maybe this is why a few people are able to reverse their health with very strict avoidance diets like Jordan Rubin [ The Makers Diet] and ELaine Gottschell [ Breaking the Vicious Cycle] . When Bill was first diagnosed we tried this and we found it very difficult. If you are only allergic to gluten or citrus, maybe you can avoid it but in Bill's case he has tree allergies, dust, animals , raw fruits and veges and milk just to name a few. So how much of PSC might be allergy driven vs. infectious? Or is it like CF and mostly a genetic predisposition to excess or thicker bile and mucous causing damage to lungs and bile ducts? It seems that we need to come up with the right questions before we can get the right answers. I'm hoping that this is what the new data base will help us to do.Lee > It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC. Bills eosinophils are still elevated. Dear Lee; The connection(s) between elevated eosinophils and PSC might be related to asthma and allergies, and may in part be genetically determined. For instance, there's a connection between interleukin- 10 gene variants and elevated eosinophils in asthma. Interleukin-10 is one of the candidate inflammatory bowel disease genes ... mice deficient in interleukin-10 develop colitis. Interleukin-10 may be required for the proper control of T cells to inhibit inflammatory diseases such as asthma and IBD. But there could be many interactions with other genes, pathogens, and other environmental factors. I wish I knew how all the puzzle pieces fit together! Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 I also wish we knew how this puzzle went together. I have a hunch that the elevated eosinophils is important somehow.PSC seems so tied in to the allergies.As if the internal digestive system was inflamed from an allergic source.Maybe this is why a few people are able to reverse their health with very strict avoidance diets like Jordan Rubin [ The Makers Diet] and ELaine Gottschell [ Breaking the Vicious Cycle] . When Bill was first diagnosed we tried this and we found it very difficult. If you are only allergic to gluten or citrus, maybe you can avoid it but in Bill's case he has tree allergies, dust, animals , raw fruits and veges and milk just to name a few. So how much of PSC might be allergy driven vs. infectious? Or is it like CF and mostly a genetic predisposition to excess or thicker bile and mucous causing damage to lungs and bile ducts? It seems that we need to come up with the right questions before we can get the right answers. I'm hoping that this is what the new data base will help us to do.Lee > It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC. Bills eosinophils are still elevated. Dear Lee; The connection(s) between elevated eosinophils and PSC might be related to asthma and allergies, and may in part be genetically determined. For instance, there's a connection between interleukin- 10 gene variants and elevated eosinophils in asthma. Interleukin-10 is one of the candidate inflammatory bowel disease genes ... mice deficient in interleukin-10 develop colitis. Interleukin-10 may be required for the proper control of T cells to inhibit inflammatory diseases such as asthma and IBD. But there could be many interactions with other genes, pathogens, and other environmental factors. I wish I knew how all the puzzle pieces fit together! Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2006 Report Share Posted May 23, 2006 I also wish we knew how this puzzle went together. I have a hunch that the elevated eosinophils is important somehow.PSC seems so tied in to the allergies.As if the internal digestive system was inflamed from an allergic source.Maybe this is why a few people are able to reverse their health with very strict avoidance diets like Jordan Rubin [ The Makers Diet] and ELaine Gottschell [ Breaking the Vicious Cycle] . When Bill was first diagnosed we tried this and we found it very difficult. If you are only allergic to gluten or citrus, maybe you can avoid it but in Bill's case he has tree allergies, dust, animals , raw fruits and veges and milk just to name a few. So how much of PSC might be allergy driven vs. infectious? Or is it like CF and mostly a genetic predisposition to excess or thicker bile and mucous causing damage to lungs and bile ducts? It seems that we need to come up with the right questions before we can get the right answers. I'm hoping that this is what the new data base will help us to do.Lee > It is strange how this "eosinophils" business keeps showing up and I just wonder what all the connection is with PSC. Bills eosinophils are still elevated. Dear Lee; The connection(s) between elevated eosinophils and PSC might be related to asthma and allergies, and may in part be genetically determined. For instance, there's a connection between interleukin- 10 gene variants and elevated eosinophils in asthma. Interleukin-10 is one of the candidate inflammatory bowel disease genes ... mice deficient in interleukin-10 develop colitis. Interleukin-10 may be required for the proper control of T cells to inhibit inflammatory diseases such as asthma and IBD. But there could be many interactions with other genes, pathogens, and other environmental factors. I wish I knew how all the puzzle pieces fit together! Best regards, Dave (father of (20); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
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