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> > what is actually killing these 1 in 4 people post tx after say

the

> > first year?

> >

C

Liver Transpl. 2001 Sep;7(9):811-5.

Analysis of causes of death in liver transplant recipients who

survived more than 3 years.

Pruthi J, Medkiff KA, Esrason KT, Donovan JA, Yoshida EM, Erb SR,

Steinbrecher UP, Fong TL.

Division of Liver Transplantation, Southern California Permanente

Medical Group, Los Angeles, CA, USA.

Few studies have examined causes of death in long-term survivors of

orthotopic liver transplantation (OLT). We reviewed causes of death

among 299 adult liver transplant recipients who survived more than 3

years after OLT at 2 centers. Thirty-eight of the 299 patients

subsequently died. Nonhepatic causes accounted for 22 of 38 late

deaths (58%). Death caused by malignancies occurred in 9 patients

between 3.3 and 8.0 years after OLT. Eight patients died of

cardiovascular complications. The 6 patients who died of myocardial

infarction had risk factors for coronary artery disease. Hepatic

failure caused by recurrent liver disease or chronic rejection

accounted for 16 of 38 late deaths (42%). These 16 patients were

younger than patients who died of nonhepatic complications (mean

ages, 50.7 v 62.1 years; P =.001). However, the mean interval

between OLT and death was similar among patients who died of

nonhepatic versus hepatic causes. Nine patients had recurrent liver

disease leading to death, and 8 of 9 patients had recurrent chronic

hepatitis C virus (HCV) infection. Chronic rejection resulting in

graft failure and death occurred in 7 patients. In summary, de novo

malignancies and cardiovascular complications accounted for more

than half the late deaths. Patients who died of nonhepatic causes

were significantly older than patients who died of hepatic causes.

Chronic rejection and recurrent HCV infection accounted for the

majority of hepatic causes of death. With longer follow-up, graft

failure resulting from recurrent HCV infection will become the major

cause of death in late survivors.

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> > what is actually killing these 1 in 4 people post tx after say

the

> > first year?

> >

C

Liver Transpl. 2001 Sep;7(9):811-5.

Analysis of causes of death in liver transplant recipients who

survived more than 3 years.

Pruthi J, Medkiff KA, Esrason KT, Donovan JA, Yoshida EM, Erb SR,

Steinbrecher UP, Fong TL.

Division of Liver Transplantation, Southern California Permanente

Medical Group, Los Angeles, CA, USA.

Few studies have examined causes of death in long-term survivors of

orthotopic liver transplantation (OLT). We reviewed causes of death

among 299 adult liver transplant recipients who survived more than 3

years after OLT at 2 centers. Thirty-eight of the 299 patients

subsequently died. Nonhepatic causes accounted for 22 of 38 late

deaths (58%). Death caused by malignancies occurred in 9 patients

between 3.3 and 8.0 years after OLT. Eight patients died of

cardiovascular complications. The 6 patients who died of myocardial

infarction had risk factors for coronary artery disease. Hepatic

failure caused by recurrent liver disease or chronic rejection

accounted for 16 of 38 late deaths (42%). These 16 patients were

younger than patients who died of nonhepatic complications (mean

ages, 50.7 v 62.1 years; P =.001). However, the mean interval

between OLT and death was similar among patients who died of

nonhepatic versus hepatic causes. Nine patients had recurrent liver

disease leading to death, and 8 of 9 patients had recurrent chronic

hepatitis C virus (HCV) infection. Chronic rejection resulting in

graft failure and death occurred in 7 patients. In summary, de novo

malignancies and cardiovascular complications accounted for more

than half the late deaths. Patients who died of nonhepatic causes

were significantly older than patients who died of hepatic causes.

Chronic rejection and recurrent HCV infection accounted for the

majority of hepatic causes of death. With longer follow-up, graft

failure resulting from recurrent HCV infection will become the major

cause of death in late survivors.

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> > what is actually killing these 1 in 4 people post tx after say

the

> > first year?

> >

C

Liver Transpl. 2001 Sep;7(9):811-5.

Analysis of causes of death in liver transplant recipients who

survived more than 3 years.

Pruthi J, Medkiff KA, Esrason KT, Donovan JA, Yoshida EM, Erb SR,

Steinbrecher UP, Fong TL.

Division of Liver Transplantation, Southern California Permanente

Medical Group, Los Angeles, CA, USA.

Few studies have examined causes of death in long-term survivors of

orthotopic liver transplantation (OLT). We reviewed causes of death

among 299 adult liver transplant recipients who survived more than 3

years after OLT at 2 centers. Thirty-eight of the 299 patients

subsequently died. Nonhepatic causes accounted for 22 of 38 late

deaths (58%). Death caused by malignancies occurred in 9 patients

between 3.3 and 8.0 years after OLT. Eight patients died of

cardiovascular complications. The 6 patients who died of myocardial

infarction had risk factors for coronary artery disease. Hepatic

failure caused by recurrent liver disease or chronic rejection

accounted for 16 of 38 late deaths (42%). These 16 patients were

younger than patients who died of nonhepatic complications (mean

ages, 50.7 v 62.1 years; P =.001). However, the mean interval

between OLT and death was similar among patients who died of

nonhepatic versus hepatic causes. Nine patients had recurrent liver

disease leading to death, and 8 of 9 patients had recurrent chronic

hepatitis C virus (HCV) infection. Chronic rejection resulting in

graft failure and death occurred in 7 patients. In summary, de novo

malignancies and cardiovascular complications accounted for more

than half the late deaths. Patients who died of nonhepatic causes

were significantly older than patients who died of hepatic causes.

Chronic rejection and recurrent HCV infection accounted for the

majority of hepatic causes of death. With longer follow-up, graft

failure resulting from recurrent HCV infection will become the major

cause of death in late survivors.

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>

> Liver Transpl. 2001 Sep;7(9):811-5.

>

>

> Analysis of causes of death in liver transplant recipients who

> survived more than 3 years.

>

> Thanks for this.

I note from this that some many deaths are none 'liver' reasons eg

heart etc. Some are recurrent hep c. Does anybody know if there have

been any studies on psc patients. Could it be assumed for example

that PSC people post tx might have better outcomes assuming they

don't have hep C etc? Or do we assume that the same 1:4 approx will

die post 5 years tx.

Thanks

Tim (UK) psc 01 uc 03

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>

> Liver Transpl. 2001 Sep;7(9):811-5.

>

>

> Analysis of causes of death in liver transplant recipients who

> survived more than 3 years.

>

> Thanks for this.

I note from this that some many deaths are none 'liver' reasons eg

heart etc. Some are recurrent hep c. Does anybody know if there have

been any studies on psc patients. Could it be assumed for example

that PSC people post tx might have better outcomes assuming they

don't have hep C etc? Or do we assume that the same 1:4 approx will

die post 5 years tx.

Thanks

Tim (UK) psc 01 uc 03

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Hi Tim;

The Mayo Clinic has published this article on long-term outcomes

after liver transplantation for PSC. It sounds like the major cause

of death was severe infection:

Hepatology. 1999 Nov;30(5):1121-7.

Long-term results of patients undergoing liver transplantation for

primary sclerosing cholangitis.

Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton

MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA.

Liver Transplant Unit, Mayo Clinic, Rochester, MN 55905, USA.

Liver transplantation is the only effective therapeutic option for

patients with end-stage liver disease due to primary sclerosing

cholangitis (PSC). In this study, we analyzed a single center's

experience with 150 consecutive PSC patients who received 174 liver

allografts. Mean follow-up was 55 months. Actuarial patient survival

at 1, 2, 5, and 10 years was 93.7%, 92.2%, 86.4%, and 69.8%,

respectively, whereas graft survival was 83.4%, 83.4%, 79.0%, and

60.5%, respectively. The main indication for retransplantation was

hepatic artery thrombosis, and the major cause of death was severe

infection. Patients with PSC had a higher incidence of acute

cellular and chronic ductopenic rejection compared to a non-PSC

control group. Chronic ductopenic rejection adversely affected

patient and graft survival. Biliary strictures, both anastomotic and

nonanastomotic, were frequent and occurred in 16.2% and 27.2% of

patients, respectively. The incidence of recurrent PSC was 20%. A

negative impact on patient survival was not seen in patients with

either postoperative biliary strictures or recurrence of PSC. Six

patients (4%) had cholangiocarcinoma and 1 patient died related to

recurrence of malignant disease. Seventy-eight percent of PSC

patients had associated inflammatory bowel disease, most commonly

chronic ulcerative colitis, which did not adversely impact patient

outcome posttransplantation. Nine patients required proctocolectomy

after liver transplantation; 5 because of intractable symptoms

related to inflammatory bowel disease and 4 due to the development

of colorectal carcinoma/high-grade dysplasia. Our data show that

liver transplantation provides excellent long-term patient and graft

survival for patients with end-stage PSC. PMID: 10534330.

Best regards,

Dave

(father of (21); PSC 07/03; UC 08/03)

> Does anybody know if there have been any studies on psc patients.

Could it be assumed for example that PSC people post tx might have

better outcomes assuming they don't have hep C etc? Or do we assume

that the same 1:4 approx will die post 5 years tx.

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Thank you bery much that's exactly what I was looking for. U amaze me

how u come up with the goods all the time!

Tim

>

> Hi Tim;

>

> The Mayo Clinic has published this article on long-term outcomes

> after liver transplantation for PSC. It sounds like the major cause

> of death was severe infection:

>

>

D

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Thank you bery much that's exactly what I was looking for. U amaze me

how u come up with the goods all the time!

Tim

>

> Hi Tim;

>

> The Mayo Clinic has published this article on long-term outcomes

> after liver transplantation for PSC. It sounds like the major cause

> of death was severe infection:

>

>

D

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Thank you bery much that's exactly what I was looking for. U amaze me

how u come up with the goods all the time!

Tim

>

> Hi Tim;

>

> The Mayo Clinic has published this article on long-term outcomes

> after liver transplantation for PSC. It sounds like the major cause

> of death was severe infection:

>

>

D

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Thanks Tim

That is quite encouraging showing that if you have to have a liver

disease this is I guess one of the better ones in terms of tx. I still

wish that 20% was even less!

Tim (UK)

>

> According to Table 9.11a, Adjusted Patient Survival, Deceased Donor

> Liver Transplants, Survival at 3 Months, 1 Year, 3 Years, and 5

Years

> based on Primary Diagnosis, 3 classes of diagnosis (Cholestatic

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I donated 60% of my liver to my Husband on October 16th. He did

really good for the first couple of days, but then developed a major

infection. They are still trying to find out where it came from. He is

having an MRI late tonight and he may need another transplant because the

antibiotics are attacking the new liver. I was discharged today and am

getting better physically everyday, but I am on an emotional roller

coaster... I will keep eveyone posted.

>

>Reply-To:

>To:

>Subject: Re: Reasons to die post tx

>Date: Mon, 23 Oct 2006 15:05:21 -0000

>

>Hi Tim;

>

>The Mayo Clinic has published this article on long-term outcomes

>after liver transplantation for PSC. It sounds like the major cause

>of death was severe infection:

>

>Hepatology. 1999 Nov;30(5):1121-7.

>

>Long-term results of patients undergoing liver transplantation for

>primary sclerosing cholangitis.

>

>Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton

>MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA.

>

>Liver Transplant Unit, Mayo Clinic, Rochester, MN 55905, USA.

>

>Liver transplantation is the only effective therapeutic option for

>patients with end-stage liver disease due to primary sclerosing

>cholangitis (PSC). In this study, we analyzed a single center's

>experience with 150 consecutive PSC patients who received 174 liver

>allografts. Mean follow-up was 55 months. Actuarial patient survival

>at 1, 2, 5, and 10 years was 93.7%, 92.2%, 86.4%, and 69.8%,

>respectively, whereas graft survival was 83.4%, 83.4%, 79.0%, and

>60.5%, respectively. The main indication for retransplantation was

>hepatic artery thrombosis, and the major cause of death was severe

>infection. Patients with PSC had a higher incidence of acute

>cellular and chronic ductopenic rejection compared to a non-PSC

>control group. Chronic ductopenic rejection adversely affected

>patient and graft survival. Biliary strictures, both anastomotic and

>nonanastomotic, were frequent and occurred in 16.2% and 27.2% of

>patients, respectively. The incidence of recurrent PSC was 20%. A

>negative impact on patient survival was not seen in patients with

>either postoperative biliary strictures or recurrence of PSC. Six

>patients (4%) had cholangiocarcinoma and 1 patient died related to

>recurrence of malignant disease. Seventy-eight percent of PSC

>patients had associated inflammatory bowel disease, most commonly

>chronic ulcerative colitis, which did not adversely impact patient

>outcome posttransplantation. Nine patients required proctocolectomy

>after liver transplantation; 5 because of intractable symptoms

>related to inflammatory bowel disease and 4 due to the development

>of colorectal carcinoma/high-grade dysplasia. Our data show that

>liver transplantation provides excellent long-term patient and graft

>survival for patients with end-stage PSC. PMID: 10534330.

>

>Best regards,

>

>Dave

>(father of (21); PSC 07/03; UC 08/03)

>

>

>

>

> > Does anybody know if there have been any studies on psc patients.

>Could it be assumed for example that PSC people post tx might have

>better outcomes assuming they don't have hep C etc? Or do we assume

>that the same 1:4 approx will die post 5 years tx.

>

>

>

_________________________________________________________________

Stay in touch with old friends and meet new ones with Windows Live Spaces

http://clk.atdmt.com/MSN/go/msnnkwsp0070000001msn/direct/01/?href=http://spaces.\

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I donated 60% of my liver to my Husband on October 16th. He did

really good for the first couple of days, but then developed a major

infection. They are still trying to find out where it came from. He is

having an MRI late tonight and he may need another transplant because the

antibiotics are attacking the new liver. I was discharged today and am

getting better physically everyday, but I am on an emotional roller

coaster... I will keep eveyone posted.

>

>Reply-To:

>To:

>Subject: Re: Reasons to die post tx

>Date: Mon, 23 Oct 2006 15:05:21 -0000

>

>Hi Tim;

>

>The Mayo Clinic has published this article on long-term outcomes

>after liver transplantation for PSC. It sounds like the major cause

>of death was severe infection:

>

>Hepatology. 1999 Nov;30(5):1121-7.

>

>Long-term results of patients undergoing liver transplantation for

>primary sclerosing cholangitis.

>

>Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton

>MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA.

>

>Liver Transplant Unit, Mayo Clinic, Rochester, MN 55905, USA.

>

>Liver transplantation is the only effective therapeutic option for

>patients with end-stage liver disease due to primary sclerosing

>cholangitis (PSC). In this study, we analyzed a single center's

>experience with 150 consecutive PSC patients who received 174 liver

>allografts. Mean follow-up was 55 months. Actuarial patient survival

>at 1, 2, 5, and 10 years was 93.7%, 92.2%, 86.4%, and 69.8%,

>respectively, whereas graft survival was 83.4%, 83.4%, 79.0%, and

>60.5%, respectively. The main indication for retransplantation was

>hepatic artery thrombosis, and the major cause of death was severe

>infection. Patients with PSC had a higher incidence of acute

>cellular and chronic ductopenic rejection compared to a non-PSC

>control group. Chronic ductopenic rejection adversely affected

>patient and graft survival. Biliary strictures, both anastomotic and

>nonanastomotic, were frequent and occurred in 16.2% and 27.2% of

>patients, respectively. The incidence of recurrent PSC was 20%. A

>negative impact on patient survival was not seen in patients with

>either postoperative biliary strictures or recurrence of PSC. Six

>patients (4%) had cholangiocarcinoma and 1 patient died related to

>recurrence of malignant disease. Seventy-eight percent of PSC

>patients had associated inflammatory bowel disease, most commonly

>chronic ulcerative colitis, which did not adversely impact patient

>outcome posttransplantation. Nine patients required proctocolectomy

>after liver transplantation; 5 because of intractable symptoms

>related to inflammatory bowel disease and 4 due to the development

>of colorectal carcinoma/high-grade dysplasia. Our data show that

>liver transplantation provides excellent long-term patient and graft

>survival for patients with end-stage PSC. PMID: 10534330.

>

>Best regards,

>

>Dave

>(father of (21); PSC 07/03; UC 08/03)

>

>

>

>

> > Does anybody know if there have been any studies on psc patients.

>Could it be assumed for example that PSC people post tx might have

>better outcomes assuming they don't have hep C etc? Or do we assume

>that the same 1:4 approx will die post 5 years tx.

>

>

>

_________________________________________________________________

Stay in touch with old friends and meet new ones with Windows Live Spaces

http://clk.atdmt.com/MSN/go/msnnkwsp0070000001msn/direct/01/?href=http://spaces.\

live.com/spacesapi.aspx?wx_action=create & wx_url=/friends.aspx & mkt=en-us

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I donated 60% of my liver to my Husband on October 16th. He did

really good for the first couple of days, but then developed a major

infection. They are still trying to find out where it came from. He is

having an MRI late tonight and he may need another transplant because the

antibiotics are attacking the new liver. I was discharged today and am

getting better physically everyday, but I am on an emotional roller

coaster... I will keep eveyone posted.

>

>Reply-To:

>To:

>Subject: Re: Reasons to die post tx

>Date: Mon, 23 Oct 2006 15:05:21 -0000

>

>Hi Tim;

>

>The Mayo Clinic has published this article on long-term outcomes

>after liver transplantation for PSC. It sounds like the major cause

>of death was severe infection:

>

>Hepatology. 1999 Nov;30(5):1121-7.

>

>Long-term results of patients undergoing liver transplantation for

>primary sclerosing cholangitis.

>

>Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton

>MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA.

>

>Liver Transplant Unit, Mayo Clinic, Rochester, MN 55905, USA.

>

>Liver transplantation is the only effective therapeutic option for

>patients with end-stage liver disease due to primary sclerosing

>cholangitis (PSC). In this study, we analyzed a single center's

>experience with 150 consecutive PSC patients who received 174 liver

>allografts. Mean follow-up was 55 months. Actuarial patient survival

>at 1, 2, 5, and 10 years was 93.7%, 92.2%, 86.4%, and 69.8%,

>respectively, whereas graft survival was 83.4%, 83.4%, 79.0%, and

>60.5%, respectively. The main indication for retransplantation was

>hepatic artery thrombosis, and the major cause of death was severe

>infection. Patients with PSC had a higher incidence of acute

>cellular and chronic ductopenic rejection compared to a non-PSC

>control group. Chronic ductopenic rejection adversely affected

>patient and graft survival. Biliary strictures, both anastomotic and

>nonanastomotic, were frequent and occurred in 16.2% and 27.2% of

>patients, respectively. The incidence of recurrent PSC was 20%. A

>negative impact on patient survival was not seen in patients with

>either postoperative biliary strictures or recurrence of PSC. Six

>patients (4%) had cholangiocarcinoma and 1 patient died related to

>recurrence of malignant disease. Seventy-eight percent of PSC

>patients had associated inflammatory bowel disease, most commonly

>chronic ulcerative colitis, which did not adversely impact patient

>outcome posttransplantation. Nine patients required proctocolectomy

>after liver transplantation; 5 because of intractable symptoms

>related to inflammatory bowel disease and 4 due to the development

>of colorectal carcinoma/high-grade dysplasia. Our data show that

>liver transplantation provides excellent long-term patient and graft

>survival for patients with end-stage PSC. PMID: 10534330.

>

>Best regards,

>

>Dave

>(father of (21); PSC 07/03; UC 08/03)

>

>

>

>

> > Does anybody know if there have been any studies on psc patients.

>Could it be assumed for example that PSC people post tx might have

>better outcomes assuming they don't have hep C etc? Or do we assume

>that the same 1:4 approx will die post 5 years tx.

>

>

>

_________________________________________________________________

Stay in touch with old friends and meet new ones with Windows Live Spaces

http://clk.atdmt.com/MSN/go/msnnkwsp0070000001msn/direct/01/?href=http://spaces.\

live.com/spacesapi.aspx?wx_action=create & wx_url=/friends.aspx & mkt=en-us

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Dear ,I'm sending prayers out to your husband and well wishes for you.I haven't been on line as much as I am in the middle of moving. I'm sorry that I missed this news of your generousdonation from you to your husband. I hope that they can find the source of his infection and that another transplant won't be needed.God bless you both. LeeI donated 60% of my liver to my Husband on October 16th. He did really good for the first couple of days, but then developed a major infection. 

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Dear ,I'm sending prayers out to your husband and well wishes for you.I haven't been on line as much as I am in the middle of moving. I'm sorry that I missed this news of your generousdonation from you to your husband. I hope that they can find the source of his infection and that another transplant won't be needed.God bless you both. LeeI donated 60% of my liver to my Husband on October 16th. He did really good for the first couple of days, but then developed a major infection. 

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Dear ,I'm sending prayers out to your husband and well wishes for you.I haven't been on line as much as I am in the middle of moving. I'm sorry that I missed this news of your generousdonation from you to your husband. I hope that they can find the source of his infection and that another transplant won't be needed.God bless you both. LeeI donated 60% of my liver to my Husband on October 16th. He did really good for the first couple of days, but then developed a major infection. 

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,

All my hopes are with you. My husband and I did a living donor

surgery, so I know that you're dealing with a bundle of emotions. No

matter what happens, know that your gift to was one of the

true miracles of this life. I was surprised by how overwhelming the

emotions were at the time of the surgery and just after. Add to that

the pain killers, and it was hard to cope. Whenever there are

complications involved, there are issues of guilt and second

guessing. (My husband/donor had the complications in our case, so

that was hard for me, and now I'm not " fixed " so that's hard for

him.) Know that when you decided to donate, you made the best

decision that you could given the information you had at the time.

Be there for him as much as you can, but remember that you have to

heal, too. Take good care of yourself during this crisis so that

when he recovers, you're there to help. I hope you have someone

close to you to talk to about all of this. I know that having really

patient and good listening friends really helped me get through it.

Blessings to you both!

Love,

Deb in VA

PSC 1998, UC 1999, Listed Ltx 2001, LDLTX 5/19/2005

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,

All my hopes are with you. My husband and I did a living donor

surgery, so I know that you're dealing with a bundle of emotions. No

matter what happens, know that your gift to was one of the

true miracles of this life. I was surprised by how overwhelming the

emotions were at the time of the surgery and just after. Add to that

the pain killers, and it was hard to cope. Whenever there are

complications involved, there are issues of guilt and second

guessing. (My husband/donor had the complications in our case, so

that was hard for me, and now I'm not " fixed " so that's hard for

him.) Know that when you decided to donate, you made the best

decision that you could given the information you had at the time.

Be there for him as much as you can, but remember that you have to

heal, too. Take good care of yourself during this crisis so that

when he recovers, you're there to help. I hope you have someone

close to you to talk to about all of this. I know that having really

patient and good listening friends really helped me get through it.

Blessings to you both!

Love,

Deb in VA

PSC 1998, UC 1999, Listed Ltx 2001, LDLTX 5/19/2005

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,

All my hopes are with you. My husband and I did a living donor

surgery, so I know that you're dealing with a bundle of emotions. No

matter what happens, know that your gift to was one of the

true miracles of this life. I was surprised by how overwhelming the

emotions were at the time of the surgery and just after. Add to that

the pain killers, and it was hard to cope. Whenever there are

complications involved, there are issues of guilt and second

guessing. (My husband/donor had the complications in our case, so

that was hard for me, and now I'm not " fixed " so that's hard for

him.) Know that when you decided to donate, you made the best

decision that you could given the information you had at the time.

Be there for him as much as you can, but remember that you have to

heal, too. Take good care of yourself during this crisis so that

when he recovers, you're there to help. I hope you have someone

close to you to talk to about all of this. I know that having really

patient and good listening friends really helped me get through it.

Blessings to you both!

Love,

Deb in VA

PSC 1998, UC 1999, Listed Ltx 2001, LDLTX 5/19/2005

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-Hi , Good that you are feeling better and have been discharged.

Unfortunate that your husband developed and infection. I hope all

gets sorted soon. Try and stay positive and stay healthy as you will

need each other

Rita (Florida)

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-Hi , Good that you are feeling better and have been discharged.

Unfortunate that your husband developed and infection. I hope all

gets sorted soon. Try and stay positive and stay healthy as you will

need each other

Rita (Florida)

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