Re: A hypothesis on inflammation and cholestasis (LONG)

[Guest guest]

Wow , thank you so much for this very interesting, complete and thought provoking work.I read it once and will need to read it a couple more times before I feel that I grasp it.With Bill on both urso and cipro, I have wondered about switching him to rifampin but have not brought it up with his doctor.I'm glad to see that the omega 3's might have a similar effect since Bill takes that.I will copy and save this, share it with my husband and I am sure this will be something to discuss at our next conference.It will be interesting to see if either of these therapies delay the need for transplant. Another reason to start tracking what therapies patients are using and what is working and what isn't.Thanks again for this analysis and the time it took to put it together.LeeO.K., here's a hypothesis about inflammation and cholestasis. I'd like to apologize that this is very long and very complicated.

[Guest guest]

Wow , thank you so much for this very interesting, complete and thought provoking work.I read it once and will need to read it a couple more times before I feel that I grasp it.With Bill on both urso and cipro, I have wondered about switching him to rifampin but have not brought it up with his doctor.I'm glad to see that the omega 3's might have a similar effect since Bill takes that.I will copy and save this, share it with my husband and I am sure this will be something to discuss at our next conference.It will be interesting to see if either of these therapies delay the need for transplant. Another reason to start tracking what therapies patients are using and what is working and what isn't.Thanks again for this analysis and the time it took to put it together.LeeO.K., here's a hypothesis about inflammation and cholestasis. I'd like to apologize that this is very long and very complicated.

[Guest guest]

Wow , thank you so much for this very interesting, complete and thought provoking work.I read it once and will need to read it a couple more times before I feel that I grasp it.With Bill on both urso and cipro, I have wondered about switching him to rifampin but have not brought it up with his doctor.I'm glad to see that the omega 3's might have a similar effect since Bill takes that.I will copy and save this, share it with my husband and I am sure this will be something to discuss at our next conference.It will be interesting to see if either of these therapies delay the need for transplant. Another reason to start tracking what therapies patients are using and what is working and what isn't.Thanks again for this analysis and the time it took to put it together.LeeO.K., here's a hypothesis about inflammation and cholestasis. I'd like to apologize that this is very long and very complicated.

[Guest guest]

So, , as someone who never got past freshman biology, could it

be that my PSC was started from a case of " blood poisoning " in

seventh grade? Of course, my doctor made this diagnosis based on

clinical findings, not blood cultures - and I'm not at all surprised

that he used the lay term instead of sepsis. The only reason I knew

it was serious was because this was one of the few times that my

pediatrician actually looked like he was worried about me, like I

wasn't faking. All I thought I had was an infected cut on my hand.

I just took oral antibiotics, but of the three things mentioned at

the end of your piece, this is the only thing I can think of that

would relate in my past...besides just being one sickly kid.

Just curious what your thoughts are since I know we'll never have a

definitive answer. If it started that early, then it would explain

my rapid progression following high school and college. (The fatigue

showed up my senior year of high school, and cholangitis my senior

year of college.)

Thanks,

Deb in VA

PSC 1998, UC 1999, Listed Ltx 2001, LDLTX 5/19/2005

This may explain the beneficial effects of omega-3 fatty

> acids in trauma, burn injury, and sepsis (Calder, 2006).

> Interestingly all of these conditions can lead to sclerosing

> cholangitis (Schmitt et al., 1997; Engler et al., 2003; Benninger

et

> al., 2005).

[Guest guest]

So, , as someone who never got past freshman biology, could it

be that my PSC was started from a case of " blood poisoning " in

seventh grade? Of course, my doctor made this diagnosis based on

clinical findings, not blood cultures - and I'm not at all surprised

that he used the lay term instead of sepsis. The only reason I knew

it was serious was because this was one of the few times that my

pediatrician actually looked like he was worried about me, like I

wasn't faking. All I thought I had was an infected cut on my hand.

I just took oral antibiotics, but of the three things mentioned at

the end of your piece, this is the only thing I can think of that

would relate in my past...besides just being one sickly kid.

Just curious what your thoughts are since I know we'll never have a

definitive answer. If it started that early, then it would explain

my rapid progression following high school and college. (The fatigue

showed up my senior year of high school, and cholangitis my senior

year of college.)

Thanks,

Deb in VA

PSC 1998, UC 1999, Listed Ltx 2001, LDLTX 5/19/2005

This may explain the beneficial effects of omega-3 fatty

> acids in trauma, burn injury, and sepsis (Calder, 2006).

> Interestingly all of these conditions can lead to sclerosing

> cholangitis (Schmitt et al., 1997; Engler et al., 2003; Benninger

et

> al., 2005).

[Guest guest]

Yes, thanks, , for putting this out there for us to digest. With

the help of Wikipedia and your paper, I think I'm finally beginning to

get some understanding of the chemistry terms you all are always

talking about... tx,

Nina

husband PSC 4/06

>

> O.K., here's a hypothesis about inflammation and cholestasis. I'd

> like to apologize that this is very long and very complicated.

[Guest guest]

Yes, thanks, , for putting this out there for us to digest. With

the help of Wikipedia and your paper, I think I'm finally beginning to

get some understanding of the chemistry terms you all are always

talking about... tx,

Nina

husband PSC 4/06

>

> O.K., here's a hypothesis about inflammation and cholestasis. I'd

> like to apologize that this is very long and very complicated.

[Guest guest]

Yes, thanks, , for putting this out there for us to digest. With

the help of Wikipedia and your paper, I think I'm finally beginning to

get some understanding of the chemistry terms you all are always

talking about... tx,

Nina

husband PSC 4/06

>

> O.K., here's a hypothesis about inflammation and cholestasis. I'd

> like to apologize that this is very long and very complicated.

[Guest guest]

wrote:

>

> ..... This may explain the beneficial effects of omega-3 fatty

> acids in trauma, burn injury, and sepsis (Calder, 2006).

> Interestingly all of these conditions can lead to sclerosing

> cholangitis (Schmitt et al., 1997; Engler et al., 2003; Benninger et

> al., 2005).

OK ... for what it's worth -- when I was 14 I suffered considerable

trauma. I was riding my bike (and obeying all the rules of the road, I

might add) when I was hit by a car. I spent 3 days in the hospital and

went home with plenty of plaster casting, bruises, lacerations, etc. My

Mom has always maintained that I've never been the same since then.

Heaven knows, I was always healthy before then, and have been extremely

unhealthy since I was about 17 or 18.

Quite some years ago my Mom read something somewhere about serious

trauma injuries leading to autoimmune problems.

Regards,

Carolyn B. in SC

[Guest guest]

wrote:

>

> ..... This may explain the beneficial effects of omega-3 fatty

> acids in trauma, burn injury, and sepsis (Calder, 2006).

> Interestingly all of these conditions can lead to sclerosing

> cholangitis (Schmitt et al., 1997; Engler et al., 2003; Benninger et

> al., 2005).

OK ... for what it's worth -- when I was 14 I suffered considerable

trauma. I was riding my bike (and obeying all the rules of the road, I

might add) when I was hit by a car. I spent 3 days in the hospital and

went home with plenty of plaster casting, bruises, lacerations, etc. My

Mom has always maintained that I've never been the same since then.

Heaven knows, I was always healthy before then, and have been extremely

unhealthy since I was about 17 or 18.

Quite some years ago my Mom read something somewhere about serious

trauma injuries leading to autoimmune problems.

Regards,

Carolyn B. in SC

[Guest guest]

wrote:

>

> ..... This may explain the beneficial effects of omega-3 fatty

> acids in trauma, burn injury, and sepsis (Calder, 2006).

> Interestingly all of these conditions can lead to sclerosing

> cholangitis (Schmitt et al., 1997; Engler et al., 2003; Benninger et

> al., 2005).

OK ... for what it's worth -- when I was 14 I suffered considerable

trauma. I was riding my bike (and obeying all the rules of the road, I

might add) when I was hit by a car. I spent 3 days in the hospital and

went home with plenty of plaster casting, bruises, lacerations, etc. My

Mom has always maintained that I've never been the same since then.

Heaven knows, I was always healthy before then, and have been extremely

unhealthy since I was about 17 or 18.

Quite some years ago my Mom read something somewhere about serious

trauma injuries leading to autoimmune problems.

Regards,

Carolyn B. in SC