Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 You *can* switch to 25mg every 6 hours (which is equivalent to 12.5mg every 3 hours). Because the half-life is 6-8 hours, it shouldn't really matter how often you dose *within* that timeframe (the only thing that matters is total dosage). So feel free to switch back to 6 hour dosing which is much easier to do. . In frequent-dose-chelation , " Anne " wrote: > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 You *can* switch to 25mg every 6 hours (which is equivalent to 12.5mg every 3 hours). Because the half-life is 6-8 hours, it shouldn't really matter how often you dose *within* that timeframe (the only thing that matters is total dosage). So feel free to switch back to 6 hour dosing which is much easier to do. . In frequent-dose-chelation , " Anne " wrote: > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 You *can* switch to 25mg every 6 hours (which is equivalent to 12.5mg every 3 hours). Because the half-life is 6-8 hours, it shouldn't really matter how often you dose *within* that timeframe (the only thing that matters is total dosage). So feel free to switch back to 6 hour dosing which is much easier to do. . In frequent-dose-chelation , " Anne " wrote: > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs TK--- the math works slightly differently, because you are taking it at less than half its half life the blood concentration will rise higher than it would be than if you were taking 25mg/6hr. > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? TK--- yes, I would stop the round after the third day and see how you do. If you do fine on this dosage you may be able to use 25mg/6hr > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs TK--- the math works slightly differently, because you are taking it at less than half its half life the blood concentration will rise higher than it would be than if you were taking 25mg/6hr. > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? TK--- yes, I would stop the round after the third day and see how you do. If you do fine on this dosage you may be able to use 25mg/6hr > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs TK--- the math works slightly differently, because you are taking it at less than half its half life the blood concentration will rise higher than it would be than if you were taking 25mg/6hr. > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? TK--- yes, I would stop the round after the third day and see how you do. If you do fine on this dosage you may be able to use 25mg/6hr > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > I started a round on DMPS a couple of days ago and though I know > you > > only need to take it every 6-8 hrs I forgot this due to being so > used > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > that > > would be almost equivalent to taking 25mg every 6 hrs > > > TK--- the math works slightly differently, because you are taking it > at less than half its half life the blood concentration will rise > higher than it would be than if you were taking 25mg/6hr. You are right (strictly speaking) the 2 cases are slightly different, but the other way around. Taking 25mg/6hr will give higher peak blood concentrations, but also lower trough blood concentrations. 12.5mg/3hr will give more stable average blood levels. But both schedules should be acceptable since they are within the half-life. . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > I started a round on DMPS a couple of days ago and though I know > you > > only need to take it every 6-8 hrs I forgot this due to being so > used > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > that > > would be almost equivalent to taking 25mg every 6 hrs > > > TK--- the math works slightly differently, because you are taking it > at less than half its half life the blood concentration will rise > higher than it would be than if you were taking 25mg/6hr. You are right (strictly speaking) the 2 cases are slightly different, but the other way around. Taking 25mg/6hr will give higher peak blood concentrations, but also lower trough blood concentrations. 12.5mg/3hr will give more stable average blood levels. But both schedules should be acceptable since they are within the half-life. . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > Hi everyone, > > > > I started a round on DMPS a couple of days ago and though I know > you > > only need to take it every 6-8 hrs I forgot this due to being so > used > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > that > > would be almost equivalent to taking 25mg every 6 hrs > > > TK--- the math works slightly differently, because you are taking it > at less than half its half life the blood concentration will rise > higher than it would be than if you were taking 25mg/6hr. Thanks TK, I dont understand, as I'm taking 12.5mg 3hrly, why would that be different to taking 25mg 6 hrly? As that is half the half life. Or do you mean the pharmacology of taking 12.5 is different to 25mg? So its not advisable to switch mid round? My head is quite foggy so I cant work it out, a sign I need to stop the round I think. Anne > > I'm also presuming I should carry on at this hourly rate until the > end > > of this round rather than change to every 6hrs during this round? > > TK--- yes, I would stop the round after the third day and see how > you do. If you do fine on this dosage you may be able to use > 25mg/6hr > > > > > > > Thanks, > > > > Anne > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > Hi everyone, > > > > I started a round on DMPS a couple of days ago and though I know > you > > only need to take it every 6-8 hrs I forgot this due to being so > used > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > that > > would be almost equivalent to taking 25mg every 6 hrs > > > TK--- the math works slightly differently, because you are taking it > at less than half its half life the blood concentration will rise > higher than it would be than if you were taking 25mg/6hr. Thanks TK, I dont understand, as I'm taking 12.5mg 3hrly, why would that be different to taking 25mg 6 hrly? As that is half the half life. Or do you mean the pharmacology of taking 12.5 is different to 25mg? So its not advisable to switch mid round? My head is quite foggy so I cant work it out, a sign I need to stop the round I think. Anne > > I'm also presuming I should carry on at this hourly rate until the > end > > of this round rather than change to every 6hrs during this round? > > TK--- yes, I would stop the round after the third day and see how > you do. If you do fine on this dosage you may be able to use > 25mg/6hr > > > > > > > Thanks, > > > > Anne > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > Hi everyone, > > > > I started a round on DMPS a couple of days ago and though I know > you > > only need to take it every 6-8 hrs I forgot this due to being so > used > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > that > > would be almost equivalent to taking 25mg every 6 hrs > > > TK--- the math works slightly differently, because you are taking it > at less than half its half life the blood concentration will rise > higher than it would be than if you were taking 25mg/6hr. Thanks TK, I dont understand, as I'm taking 12.5mg 3hrly, why would that be different to taking 25mg 6 hrly? As that is half the half life. Or do you mean the pharmacology of taking 12.5 is different to 25mg? So its not advisable to switch mid round? My head is quite foggy so I cant work it out, a sign I need to stop the round I think. Anne > > I'm also presuming I should carry on at this hourly rate until the > end > > of this round rather than change to every 6hrs during this round? > > TK--- yes, I would stop the round after the third day and see how > you do. If you do fine on this dosage you may be able to use > 25mg/6hr > > > > > > > Thanks, > > > > Anne > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > > I started a round on DMPS a couple of days ago and though I know > > you > > > only need to take it every 6-8 hrs I forgot this due to being so > > used > > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > > that > > > would be almost equivalent to taking 25mg every 6 hrs > > > > > > TK--- the math works slightly differently, because you are taking it > > at less than half its half life the blood concentration will rise > > higher than it would be than if you were taking 25mg/6hr. > > You are right (strictly speaking) the 2 cases are slightly different, > but the other way around. Taking 25mg/6hr will give higher peak blood > concentrations, but also lower trough blood concentrations. 12.5mg/3hr > will give more stable average blood levels. But both schedules should > be acceptable since they are within the half-life. > > . Yes that makes more sense, but I have had to stop the round anyway. Thanks ! Anne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > > I started a round on DMPS a couple of days ago and though I know > > you > > > only need to take it every 6-8 hrs I forgot this due to being so > > used > > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > > that > > > would be almost equivalent to taking 25mg every 6 hrs > > > > > > TK--- the math works slightly differently, because you are taking it > > at less than half its half life the blood concentration will rise > > higher than it would be than if you were taking 25mg/6hr. > > You are right (strictly speaking) the 2 cases are slightly different, > but the other way around. Taking 25mg/6hr will give higher peak blood > concentrations, but also lower trough blood concentrations. 12.5mg/3hr > will give more stable average blood levels. But both schedules should > be acceptable since they are within the half-life. > > . Yes that makes more sense, but I have had to stop the round anyway. Thanks ! Anne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 > > > > > I started a round on DMPS a couple of days ago and though I know > > you > > > only need to take it every 6-8 hrs I forgot this due to being so > > used > > > to chelating every 3 hrs. I've been taking 12.5mg, so presumably > > that > > > would be almost equivalent to taking 25mg every 6 hrs > > > > > > TK--- the math works slightly differently, because you are taking it > > at less than half its half life the blood concentration will rise > > higher than it would be than if you were taking 25mg/6hr. > > You are right (strictly speaking) the 2 cases are slightly different, > but the other way around. Taking 25mg/6hr will give higher peak blood > concentrations, but also lower trough blood concentrations. 12.5mg/3hr > will give more stable average blood levels. But both schedules should > be acceptable since they are within the half-life. > > . Yes that makes more sense, but I have had to stop the round anyway. Thanks ! Anne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 Anne May I ask you where you got the DMPS from? Was it on prescription? From what I have read I would prefer to take DMPS to DMSA. Thanks Nicola -- In frequent-dose-chelation , " Anne " wrote: > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 Anne May I ask you where you got the DMPS from? Was it on prescription? From what I have read I would prefer to take DMPS to DMSA. Thanks Nicola -- In frequent-dose-chelation , " Anne " wrote: > > Hi everyone, > > I started a round on DMPS a couple of days ago and though I know you > only need to take it every 6-8 hrs I forgot this due to being so used > to chelating every 3 hrs. I've been taking 12.5mg, so presumably that > would be almost equivalent to taking 25mg every 6 hrs > > I'm also presuming I should carry on at this hourly rate until the end > of this round rather than change to every 6hrs during this round? > > Thanks, > > Anne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 > > Thanks TK, I dont understand, as I'm taking 12.5mg 3hrly, why would > that be different to taking 25mg 6 hrly? TK--- You have to do the math correctly, there will be a difference. As that is half the half > life. TK--- The half life is 8hrs not 6hr which needs to be taken into consideration when doing the math. Or do you mean the pharmacology of taking 12.5 is different to > 25mg? TK--changing times and amounts during a round will cause fluctuations So its not advisable to switch mid round? TK--- I would suggest you stop the round if you are going to switch dosing times as there is a difference and it will cause problems with chelator fluctuations. Stick with what the protocol suggests. My head is quite > foggy so I cant work it out, a sign I need to stop the round I think. > > Anne > > > > > I'm also presuming I should carry on at this hourly rate until > the > > end > > > of this round rather than change to every 6hrs during this round? > > > > TK--- yes, I would stop the round after the third day and see how > > you do. If you do fine on this dosage you may be able to use > > 25mg/6hr > > > > > > > > > > > > Thanks, > > > > > > Anne > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 > > TK--- I would suggest you stop the round if you are going to switch > dosing times as there is a difference and it will cause problems > with chelator fluctuations. Stick with what the protocol suggests. > Sorry to keep flogging this subject -- but I thought changing the timing was OK as long as you went *under the recommended time rather than over. I generally take doses of ALA every 2.5 hours, but sometimes 3 or even 2 depending on circumstances. All dosages the same. But you're saying this is a problem? Nell Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 > > TK--- I would suggest you stop the round if you are going to switch > dosing times as there is a difference and it will cause problems > with chelator fluctuations. Stick with what the protocol suggests. > Sorry to keep flogging this subject -- but I thought changing the timing was OK as long as you went *under the recommended time rather than over. I generally take doses of ALA every 2.5 hours, but sometimes 3 or even 2 depending on circumstances. All dosages the same. But you're saying this is a problem? Nell Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 > > > > > TK--- I would suggest you stop the round if you are going to switch > > dosing times as there is a difference and it will cause problems > > with chelator fluctuations. Stick with what the protocol suggests. > > > > Sorry to keep flogging this subject -- but I thought changing the > timing was OK as long as you went *under the recommended time rather > than over. I generally take doses of ALA every 2.5 hours, but > sometimes 3 or even 2 depending on circumstances. All dosages the > same. But you're saying this is a problem? > > Nell If I understand this correctly, it is ideal to always dose at the same interval to maintain the steadiest possible blood level. If your intervals for a day are 3, 2, 3.5 2.5, 2, 2, 3.5, or something like that, you might feel okay and you might not. When you have been chelating regularly at an interval of 2.5 hours, say, and then you have a 3.5 hour interval, there is a slight dip in the blood level. For most people it will still be within a factor of 2 which is what Andy says is important. Some people will notice it and might have problems. I suppose the people who notice that dip in the blood level (I sometimes do) are ones whose personal half life is really shorter and they should keep their interval on the shorter side. I feel a lot better when I stick close to my interval, and I find it gets to be much more important later in the round. Please someone correct me if I'm wrong about any of this. -- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2006 Report Share Posted August 9, 2006 > > > > > TK--- I would suggest you stop the round if you are going to switch > > dosing times as there is a difference and it will cause problems > > with chelator fluctuations. Stick with what the protocol suggests. > > > > Sorry to keep flogging this subject -- but I thought changing the > timing was OK as long as you went *under the recommended time rather > than over. I generally take doses of ALA every 2.5 hours, but > sometimes 3 or even 2 depending on circumstances. All dosages the > same. But you're saying this is a problem? > > Nell If I understand this correctly, it is ideal to always dose at the same interval to maintain the steadiest possible blood level. If your intervals for a day are 3, 2, 3.5 2.5, 2, 2, 3.5, or something like that, you might feel okay and you might not. When you have been chelating regularly at an interval of 2.5 hours, say, and then you have a 3.5 hour interval, there is a slight dip in the blood level. For most people it will still be within a factor of 2 which is what Andy says is important. Some people will notice it and might have problems. I suppose the people who notice that dip in the blood level (I sometimes do) are ones whose personal half life is really shorter and they should keep their interval on the shorter side. I feel a lot better when I stick close to my interval, and I find it gets to be much more important later in the round. Please someone correct me if I'm wrong about any of this. -- Quote Link to comment Share on other sites More sharing options...
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