Guest guest Posted June 3, 2006 Report Share Posted June 3, 2006 > > > > > >If you do not use it according to it's pharmacological > > >properties [half life] every three hours or more often you will be > > >using it incorrectly and redistribute Hg. > > Why can you use a chelator sooner than the half-life, but not later? TK--- Because taking it sooner does not cause a drop in blood levels. Later causes a drop and redistribution. > Like with DMSA you can take it every 2 or 3 hours from what I gather, but > not later than every 4 hours, as that is longer than its half-life (if I am > correct?). TK--- 4hr is DMSA half life. Some can stretch it to a max of 5hr but that is the cut off time for a dose before having to stop the round. You take the chelators at their half life or more frequently to keep a consistent blood level to avoid redistribution. That doesen't mean you can take it at 4hr one dose and 5hr the next as this is going to cause inconsistent blood levels and redistribution. > > Surely the DMSA will build up to 'higher and higher' levels if taking it > sooner effectively making you blood levels higher? TK--- Yes it will and but increasing the blood level as long as you are conistent does not cause redistribution. > > What happens after the half-life time is up? Does the DMSA/ALA get > destroyed/metabolized and just let go of the mercury if it is not already > excreted? TK--- After the half life serum levels start to drop and there is not as much chelator as there is Hg which is why you take another dose to keep blood levels consistent. If there is no more DMSA/ALA in the blood by having taken the next > dose on time, then it can't be mopped up again and is simply re- distributed? TK--- There is chelator left at the half life,half of it. yes if there is not enough chealtor the Hg is redistributed like at the end or a round. > > And finally is the half-life dependent on two factors: 1) the measured > half-life as measured in a lab and 2) the speed of metabolism of a person, > or state of detox pathways. TK--- Yes which is why some people need to take it more often than others. > > On another note I ordered the books buy leaving a message on Andy's phone > and would like to confirm my order to him via email as I ordered from South > Africa. Can anyone supply me with his email address please? TK--- links section > > Thanks, > Dean > Quote Link to comment Share on other sites More sharing options...
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