Effect of low-level and intermittent minocycline therapy on the growth of Mycobacterium leprae in mice.

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Effect of low-level and intermittent minocycline therapy on the growth of Mycobacterium leprae in mice.Gelber RH, Siu P, Tsang M, Alley P, Murray LPAntimicrob Agents Chemother 1991 May 35:992-4

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Antimicrob Agents Chemother • Volume 35 • Issue 5

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MEDLINE, full MEDLINE, related recordsAbstractWe evaluated the minimal concentrations of minocycline in the diet and in serum required to inhibit the growth of seven Mycobacterium leprae isolates in mice. Minocycline concentrations of 0.01 and 0.04% in the diet, which resulted in levels in serum of less than or equal to 0.17 and 0.51 microgram/ml, respectively, were consistently and completely inhibitory. Even 0.004% dietary minocycline (levels in serum, less than or equal to 0.08 microgram/ml) partially inhibited five of these strains, while 0.001% minocycline was consistently inactive. For five of these isolates, minocycline at a concentration of 0.04% in the diet given 3 days (Monday, Wednesday, Friday) and 1 day weekly completely inhibited the growth of M. leprae, and minocycline given even 1 day monthly was partially inhibitory for three of these five M. leprae isolates.MeSH

Animal; Diet; Drug Administration Schedule; Human; Leprosy, Lepromatous; Mice; Mice, Inbred BALB C; Minocycline; Mycobacterium leprae; Support, Non-U.S. Gov'tCAS Registry Number (Substance Name)10118-90-8 (Minocycline)Author AddressKuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco, California 94115-1896.

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Publication Type

Journal Article

ISSN

0066-4804

Country

UNITED STATES

Language

eng

Journal Code

6HK

Date of Entry

19910820

Entry Month

199108

Journal Subset

IM

Class Update Date

2000

Last Revision Date

20001218

Unique Identifier

91307285