Guest guest Posted April 13, 2004 Report Share Posted April 13, 2004 , Here is some info I found on a site regarding bone pain and Neupogen. In clinical trials involving over 350 patients receiving NEUPOGEN following nonmyeloablative cytotoxic chemotherapy‚ most adverse experiences were the sequelae of the underlying malignancy or cytotoxic chemotherapy. In all phase 2 and 3 trials‚ medullary bone pain‚ reported in 24% of patients‚ was the only consistently observed adverse reaction attributed to NEUPOGEN therapy. This bone pain was generally reported to be of mild-to-moderate severity‚ and could be controlled in most patients with non-narcotic analgesics; infrequently‚ bone pain was severe enough to require narcotic analgesics. Bone pain was reported more frequently in patients treated with higher doses (20 to 100 mcg/kg/day) administered IV‚ and less frequently in patients treated with lower SC doses of NEUPOGEN (3 to 10 mcg/kg/day). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2004 Report Share Posted April 13, 2004 I don't want to scare anyone, and I don't know what sequelae means (symptoms caused by?) but I just wanted to share my experience with Neupogen, which I had to have in connection with my oxaliplatin last summer. I had the injectible form, but I can't recall the dosage. In any event, Neupogen caused me the worst pain I have ever experienced in my life. It was back pain that was muscular in origin. The doctors believed that the expanding bone marrow caused by the Neupogen (in combination with my weakened abdominals because of my surgery) somehow triggered intense spasms in my back muscles. The pain was so intense that I would literally crawl around screaming on the floor, even when I was on pretty heavy duty narcotics. I guess the point of sharing this is that I made sure to tell my doctor that I was having " level 10 " pain, and he cut my neupogen cycle to a shorter one. I still had the pain, but having the shots for 3 days was nowhere near the agony of having them for 7 (or 10, I can't remember now). Anyhow, my pain gradually went away after the Neupogen shots ended, but it took physical therapy, acupuncture, lidocaine patches and narcotics to even get it to budge a little. I'm good now though and I think my expericence was a bit on the extreme end of the spectrum. > , > > Here is some info I found on a site regarding bone pain and Neupogen. > > > In clinical trials involving over 350 patients receiving NEUPOGEN > following nonmyeloablative cytotoxic chemotherapy‚ most adverse > experiences were the sequelae of the underlying malignancy or > cytotoxic chemotherapy. In all phase 2 and 3 trials‚ medullary bone > pain‚ reported in 24% of patients‚ was the only consistently observed > adverse reaction attributed to NEUPOGEN therapy. This bone pain was > generally reported to be of mild-to-moderate severity‚ and could be > controlled in most patients with non-narcotic analgesics; > infrequently‚ bone pain was severe enough to require narcotic > analgesics. Bone pain was reported more frequently in patients > treated with higher doses (20 to 100 mcg/kg/day) administered IV‚ and > less frequently in patients treated with lower SC doses of NEUPOGEN > (3 to 10 mcg/kg/day). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2004 Report Share Posted April 13, 2004 I don't want to scare anyone, and I don't know what sequelae means (symptoms caused by?) but I just wanted to share my experience with Neupogen, which I had to have in connection with my oxaliplatin last summer. I had the injectible form, but I can't recall the dosage. In any event, Neupogen caused me the worst pain I have ever experienced in my life. It was back pain that was muscular in origin. The doctors believed that the expanding bone marrow caused by the Neupogen (in combination with my weakened abdominals because of my surgery) somehow triggered intense spasms in my back muscles. The pain was so intense that I would literally crawl around screaming on the floor, even when I was on pretty heavy duty narcotics. I guess the point of sharing this is that I made sure to tell my doctor that I was having " level 10 " pain, and he cut my neupogen cycle to a shorter one. I still had the pain, but having the shots for 3 days was nowhere near the agony of having them for 7 (or 10, I can't remember now). Anyhow, my pain gradually went away after the Neupogen shots ended, but it took physical therapy, acupuncture, lidocaine patches and narcotics to even get it to budge a little. I'm good now though and I think my expericence was a bit on the extreme end of the spectrum. > , > > Here is some info I found on a site regarding bone pain and Neupogen. > > > In clinical trials involving over 350 patients receiving NEUPOGEN > following nonmyeloablative cytotoxic chemotherapy‚ most adverse > experiences were the sequelae of the underlying malignancy or > cytotoxic chemotherapy. In all phase 2 and 3 trials‚ medullary bone > pain‚ reported in 24% of patients‚ was the only consistently observed > adverse reaction attributed to NEUPOGEN therapy. This bone pain was > generally reported to be of mild-to-moderate severity‚ and could be > controlled in most patients with non-narcotic analgesics; > infrequently‚ bone pain was severe enough to require narcotic > analgesics. Bone pain was reported more frequently in patients > treated with higher doses (20 to 100 mcg/kg/day) administered IV‚ and > less frequently in patients treated with lower SC doses of NEUPOGEN > (3 to 10 mcg/kg/day). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2004 Report Share Posted April 13, 2004 I don't want to scare anyone, and I don't know what sequelae means (symptoms caused by?) but I just wanted to share my experience with Neupogen, which I had to have in connection with my oxaliplatin last summer. I had the injectible form, but I can't recall the dosage. In any event, Neupogen caused me the worst pain I have ever experienced in my life. It was back pain that was muscular in origin. The doctors believed that the expanding bone marrow caused by the Neupogen (in combination with my weakened abdominals because of my surgery) somehow triggered intense spasms in my back muscles. The pain was so intense that I would literally crawl around screaming on the floor, even when I was on pretty heavy duty narcotics. I guess the point of sharing this is that I made sure to tell my doctor that I was having " level 10 " pain, and he cut my neupogen cycle to a shorter one. I still had the pain, but having the shots for 3 days was nowhere near the agony of having them for 7 (or 10, I can't remember now). Anyhow, my pain gradually went away after the Neupogen shots ended, but it took physical therapy, acupuncture, lidocaine patches and narcotics to even get it to budge a little. I'm good now though and I think my expericence was a bit on the extreme end of the spectrum. > , > > Here is some info I found on a site regarding bone pain and Neupogen. > > > In clinical trials involving over 350 patients receiving NEUPOGEN > following nonmyeloablative cytotoxic chemotherapy‚ most adverse > experiences were the sequelae of the underlying malignancy or > cytotoxic chemotherapy. In all phase 2 and 3 trials‚ medullary bone > pain‚ reported in 24% of patients‚ was the only consistently observed > adverse reaction attributed to NEUPOGEN therapy. This bone pain was > generally reported to be of mild-to-moderate severity‚ and could be > controlled in most patients with non-narcotic analgesics; > infrequently‚ bone pain was severe enough to require narcotic > analgesics. Bone pain was reported more frequently in patients > treated with higher doses (20 to 100 mcg/kg/day) administered IV‚ and > less frequently in patients treated with lower SC doses of NEUPOGEN > (3 to 10 mcg/kg/day). Quote Link to comment Share on other sites More sharing options...
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