Guest guest Posted February 24, 2004 Report Share Posted February 24, 2004 HI JAMES, Ervin, could you expand on this comment please. I'm curious to know why you think its large half life would prevent this. 1. iN MY PREVIOUS MESSAGE I JUST WANTED TO GIVE A SHORT EXPLANATION WITH THE CONCLUSION THAT NO, DON'T DO ANY EXPERIMENTS WITH AMIO, BY YOURSELF. IT IS A VERY STRONG AGENT AND ANY CHANGE MADE SHOULD BE COORDINATED WITH YOUR CARDIO. 2 LONG HALF LIFE SAYS THAT IT TAKES A LONGER PERIOD UNTIL THE MED. REACHES THE NECESSARY LEVEL TO BE EFFECTIVE. OBVIOUSLY IT WORKS IN BOTH DIRECTIONS. I.E. SLOW START AND LONGER PERIOD TO LEAVE THE SYSTEM. 3. USUALLY, AMIO. IS STARTED IN A HOSPITAL ENVIRONMENT, GIVING 800MG AMIO., GOING DOWN GRADUALLY TO 600MG, 400MG AND 200MG. ALL THESE WITHIN APPROX. 7 DAYS. THE TARGET IS 100MG IF IT IS SUFFICIENT TO HELP. 4. WITHOUT EVEN THINKING ABOUT ANY CHANG PLS. TALK TO YOUR DOC. (CARDIO.). AMIODARON IS A FAR MORE DANGEROUS MED. TO TREAT YOURSELF WITHOUT A CLOSE EYE OF YOUR CARDIO. (PERIODICAL BLOOD-TESTS ARE IMPERATIVE!!!! HOPING IT HELPS, ERVIN RE: Amiodarone (2) > Has anyone used Amiodarone to come out of Afib...and if so, was it > successful? > Answer: Amio. has a very long half life therefore I don't believe that it > could be used to stop AF. Ervin, could you expand on this comment please. I'm curious to know why you think its large half life would prevent this. The half life is related to how quickly amiodarone leaves the system. My understanding is whilst it does take long time for amiodarone to reach a steady state for long term use a single high dosage of amiodarone achieves peak plasma levels within 3—7 hours. If one is to be given it long term it is often given first at a high dosage to load the system and then the dosage is reduced. A one off high dosage is also used in ER situations to try to terminate AF. (it was tried twice on me in the ER) Many thanks -- D Backup web page - http://afibsupport.proboards23.com List owner: AFIBsupport-owner For help on how to use the group, including how to drive it via email, send a blank email to AFIBsupport-help Nothing in this message should be considered as medical advice, or should be acted upon without consultation with one's physician. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 24, 2004 Report Share Posted February 24, 2004 Actually, amiodarone is one of the most effective ones. Yes, I agree but because of it's long half life we can't use it like we use a lot of other meds. which have immediate effect. The main point, when we talk about Amiodaron is: NEVER TRY TO TREAT YOURSELF BUT UNDER YOUR CARDIO'S CLOSE SUPERVISION. Ervin RE: Amiodarone (2) > From: Driscoll > Date: 2/23/04, 5:21 PM -0500 > > > > Has anyone used Amiodarone to come out of Afib... > > and if so, was it successful? > > Answer: Amio. has a very long half life therefore > > I don't believe that it could be used to stop AF. > > Ervin, could you expand on this comment please. I'm > curious to know why you think its large half life > would prevent this. This argument, that amiodarone will not convert BECAUSE it has a long elimination half life, is rubbish - there is no correlation brtween the half life and the efficacy of a pharmacological cardioversion agent. Actually, amiodarone is one of the most effective ones. See: http://www.fpnotebook.com/CV7.htm Backup web page - http://afibsupport.proboards23.com List owner: AFIBsupport-owner For help on how to use the group, including how to drive it via email, send a blank email to AFIBsupport-help Nothing in this message should be considered as medical advice, or should be acted upon without consultation with one's physician. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 24, 2004 Report Share Posted February 24, 2004 > Actually, amiodarone is one of the most effective ones. > Yes, I agree but because of it's long half life > we can't use it like we use a lot of other meds. > which have immediate effect. Hi Ervin, I don't believe the situation is as symmetrical as you think. Amiodarone still has an immediate effect (a few hours) even though it has a long half life. > The main point, when we talk about Amiodaron is: > NEVER TRY TO TREAT YOURSELF BUT UNDER YOUR CARDIO'S > CLOSE SUPERVISION. Agreed, and should be true for all meds. If you are going to take amiodarone long term there's a few tests that should be taken before you even start. It certainly is a med that needs very close monitoring. All the best -- D Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 25, 2004 Report Share Posted February 25, 2004 > From: Ervin E. > Date: 2/24/04, 2:34 PM -0500 > > Actually, amiodarone is one of the most effective ones. > Yes, I agree but because of it's long half life > we can't use it like we use a lot of other meds. > which have immediate effect. What, you agree but disagree? There is no reason that a drug with a long elimination half time must also have a long time to cardioversion. > The main point, when we talk about Amiodaron is: > NEVER TRY TO TREAT YOURSELF BUT UNDER YOUR CARDIO'S > CLOSE SUPERVISION. > Ervin In several posts you are attempting to deflect from the issue, which is your fallacious argument that amiodarone will not convert BECAUSE it has a long elimination half life. This is the point Driscoll and I were responding to. > RE: Amiodarone (2) > > > From: Driscoll > > Date: 2/23/04, 5:21 PM -0500 > > > > > > > Has anyone used Amiodarone to come out of Afib... > > > and if so, was it successful? > > > Answer: Amio. has a very long half life therefore > > > I don't believe that it could be used to stop AF. > > > > Ervin, could you expand on this comment please. I'm > > curious to know why you think its large half life > > would prevent this. > > > This argument, that amiodarone will not convert BECAUSE > it has a long elimination half life, is rubbish - there > is no correlation brtween the half life and the efficacy > of a pharmacological cardioversion agent. > > Actually, amiodarone is one of the most effective ones. > See: http://www.fpnotebook.com/CV7.htm Quote Link to comment Share on other sites More sharing options...
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