Re: Marcia/ ~Cy

November 7, 2004

Hi ,

That is interesting to me that perhaps less of a match might be preferable.

I have never heard of that at all. I thought the closer the match the better.

At least that is what I was told.

In a message dated 11/7/2004 4:01:34 PM Pacific Standard Time,

GNCCLEVENGER@... writes:

> I read that IGA can and probably will be detected in transplant

> kidney biopsy,but most transplanted kidneys don't fail due to IGA. I

> am only speculating, but I believe 2 things. 1- is that IGA is a slow

> progressive disease and transplanted kidneys only last a certain time

> on average and 2- that the immunosuppresents you take for rejection

> keep the IGA from worsening faster.I did read that it is possible for

> the IGA to cause the new kidney to fail but is rare. The transplant

> doc told me that I will have more of a chance of IGA attacking a 6

> out of 6 kidney from my brother because it is the same tissue type as

> mine. As if I was better to have a lesser match. I am choosing I

> think to ignore that for now. Some of this is just my opinion-has

> anyone else heard the same or been told this.

> christine

>

November 7, 2004

Hi ,

You did express yourself beautifully. Your email was not in the least

condescending to anyone. One thing to remember that the majority of kidney

transplants are on older people, and also the number one cause of kidney failure

is

diabetes, so those two factors definitely impact that 20 year expectancy. IgAN

recipients are generally younger and overall in better health, and that leads

our life expectancy to be much longer. My Neph told me last month that after

my transplant, I will have a fairly normal life expectancy because of my good

overall health, excluding IgAN of course.

I hope that encourages you!

In a message dated 11/7/2004 4:22:13 PM Pacific Standard Time,

GNCCLEVENGER@... writes:

> Hi ,

> when I went for transplant work up that is what the transplant doc

> told me. My neph say's you always want best match, but transplant doc

> said I would want to watch it closer because the IGA would act as if

> his kidney was the same as mine and attack it. I was kind of taken

> aback when he said it because I was so happy to know I had a 6 out of

> 6 match, that I didn't even respond to it.

> When I was first diagnosed, I thought well I get a transplant and

> that would be that. when I found out the average life expectancy of

> living donor transplant was 20yrs, I cried. I thought it could last

> forever. at age 34 , 20yrs isn't enough. Acceptance is something I

> have learned since getting IGA and realizing you can't control

> everything so don't wast time worrying about it. I think now, I will

> deal with what will come. I know some would love a kidny for 20years,

> I do not mean to be condescending, I am just expressing how I felt-I

> feel differently now, that is why I am not going to worry about IGA

> with the new kidney when I am not even there yet.

> hope I expressed myself clearly,

> christine

November 7, 2004

Hi ,

when I went for transplant work up that is what the transplant doc

told me. My neph say's you always want best match, but transplant doc

said I would want to watch it closer because the IGA would act as if

his kidney was the same as mine and attack it. I was kind of taken

aback when he said it because I was so happy to know I had a 6 out of

6 match, that I didn't even respond to it.

When I was first diagnosed, I thought well I get a transplant and

that would be that. when I found out the average life expectancy of

living donor transplant was 20yrs, I cried. I thought it could last

forever. at age 34 , 20yrs isn't enough. Acceptance is something I

have learned since getting IGA and realizing you can't control

everything so don't wast time worrying about it. I think now, I will

deal with what will come. I know some would love a kidny for 20years,

I do not mean to be condescending, I am just expressing how I felt-I

feel differently now, that is why I am not going to worry about IGA

with the new kidney when I am not even there yet.

hope I expressed myself clearly,

christine

> Hi ,

>

> That is interesting to me that perhaps less of a match might be

preferable.

> I have never heard of that at all. I thought the closer the match

the better.

> At least that is what I was told.

>

> In a message dated 11/7/2004 4:01:34 PM Pacific Standard Time,

> GNCCLEVENGER@J... writes:

>

> > I read that IGA can and probably will be detected in transplant

> > kidney biopsy,but most transplanted kidneys don't fail due to

IGA. I

> > am only speculating, but I believe 2 things. 1- is that IGA is a

slow

> > progressive disease and transplanted kidneys only last a certain

time

> > on average and 2- that the immunosuppresents you take for

rejection

> > keep the IGA from worsening faster.I did read that it is possible

for

> > the IGA to cause the new kidney to fail but is rare. The

transplant

> > doc told me that I will have more of a chance of IGA attacking a

6

> > out of 6 kidney from my brother because it is the same tissue

type as

> > mine. As if I was better to have a lesser match. I am choosing I

> > think to ignore that for now. Some of this is just my opinion-has

> > anyone else heard the same or been told this.

> > christine

> >

>

November 8, 2004

My son has had recurrence of IgAN in his transplanted kidney. We were a

4/6 match and were told that there is a slightly higher risk in a

transplant from a family member, apparently because the family member

also may be somewhat more vulnerable to IgAN because of the genetic

connection to the person with IgAN. I don't think it's directly a

function of how good a match you are, just that you come from the the

gene pool. However, I wouldn't consider that a reason to turn down a

kidney from a relative who's a good match and a wiling donor.

Betsy

>

> > Bree,