Clinical Trial Request for Subjects with Spasticity

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NIH CLINICAL RESEARCH STUDIES

NIH is actively recruiting patients with spasticity caused by

selective corticospinal tract dysfunction (HSP and PLS):

" Spasticity: Physiologic Studies "

Number: 01-N-0148

Summary: This study will provide information about changes that

occur in the motor neurons of the spinal cord (the nerve cells

that control the muscles) when the motor cortex (the region of

the brain that controls movement) is unable to send messages

to the spinal cord and muscles in the normal way. This information

will help elucidate how the nervous system adapts after injury

or disease of the motor cortex.

All participants will have electromyography (measurement of electrical

activity in muscles) during nerve stimulation and transcranial

magnetic stimulation.

Contacts:

Patient Recruitment and Public Liaison Office

Building 61

10 Cloister Court

Bethesda, land 20892-4754

Toll Free: 1-

TTY: (local),1- (toll free)

Fax:

Electronic Mail:prpl@...

Note: Travel expenses are covered on many NIH sponsored studies.

Spastic Paraplegia Foundation, Inc.

www.sp-foundation.org

Dedicated to upper motor neuron diseases termed Hereditary Spastic

Paraplegia and Primary Lateral Sclerosis