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Did anyone see the two articles in the USA today yesterday (April 2) about

CF? One was in the entertainment section - about whether to offer CF

screening for Caucasian couples before conception, and the other was in the

sports section about a 21 year old student who has CF at the University of

Richmond who wants to throw out the first pitch at all major league ball

games in a season to promote CF awareness. Also, see the attached!

Krishnan

Mother of Santosh, 3 1/2 wcf and Leela, 19mowocf

April 2001 News

Cystic Fibrosis Foundation Receives $25 Million Pledge To Support the

Therapeutics Development Program

Bethesda, land - April 2, 2001: The Cystic Fibrosis Foundation today

received a pledge for a donation of $25 million to support its Therapeutics

Development Program, an innovative research initiative. The funds will be

used to accelerate and increase the “pipeline” of new cystic fibrosis (CF)

therapies, from drug discovery through development to evaluation, using a

specialized clinical trials network, through the Therapeutics Development

Program.

“Given the promise of today’s medical technology and research insights into

CF, the CF Foundation believes only one barrier stands between patients and

a cure: the number of dollars invested in therapeutic research,” said

J. Beall, Ph.D., president and CEO of the CF Foundation. “This substantial

gift will go a long way to help us leverage our investments in the most

dynamic new areas of science and technology.”

While the median life expectancy of people with CF now reaches the early

30s, new options must be developed quickly and safely, Beall added. “People

with CF cannot wait half their lifetimes for new treatment options.”

With this gift, the CF Foundation will support the use of cutting-edge

technology for the identification and development of new drugs to treat CF.

Building upon its platform of knowledge, the CF Foundation is now investing

in the latest biological, chemical, and genetic techniques. Technologies

such as high-throughput screening, combinatorial chemistry, functional

genomics, proteomics, and structural genomics are now being applied to CF in

the hopes of formulating new compounds and novel approaches to treat the

disease.

The CF Foundation also will use its clinical trials network to evaluate

these potential new therapies. In the past year alone, the CF Foundation

committed more than $110 million in multi-year, milestone-driven awards to

bring new technologies to CF research. The best evidence that these

initiatives are succeeding is the growing pipeline of products - now 20 -

under evaluation in preclinical and clinical studies. This generous gift

will enable the CF Foundation to continue to stimulate critical research, as

its investments in cutting-edge technologies are ultimately an investment in

the future of people with CF.

In essence, this gift will allow CF Foundation-supported researchers to make

a contribution to speeding the course of drug development. On average, it

takes 14 years and $500 million to develop a new pharmaceutical treatment,

according to industry sources. The CF Foundation aims to improve this

timetable and decrease the costs of development through its investment in CF

research.

The CF Foundation respects the donor’s wish to remain anonymous.

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