Re: Phosphorylated serine?

[Guest guest]

Which one do I want to take? I have the one I questioned about.

I am not sure of the difference between the two sorry, I am sure someone

else will tell you.

Mo

[Guest guest]

Phosphorylated serine is a variety of the form of phosphadityl serine.

Phosphadityl Serine has been shown to improve memory and help ACTH function -

thereby aiding in adrenal function.

Phosphadityl-Serine (PS) an endogogenously occurring phospholipid present in

cell membranes, and is the major acidic phospholipid in the brain.

Phosphadityl-Serine has been shown to positively effect neuronal membranes, cell

metabolism, acetycholine, norepinephrine, seratonin and dopamine.

Phosphadityl-Serine has been known to help improve acetylcholine release,

memory, depression, insomnia, stress, and aged related brain changes

Ann wrote:

I tried the phosphorylated serine last night and I think it helped!

What is

that stuff? I googled it and came up with NOTHING!

Ann s

www.janesjewel.com

[Guest guest]

http://en.wikipedia.org/wiki/Phosphorylation

Phosphorylated serine?

I tried the phosphorylated serine last night and I think it helped! What

is

that stuff? I googled it and came up with NOTHING!

Ann s

www.janesjewel.com

.

[Guest guest]

Wikipedia gave a complicated description. Anybody got a simple explanation

for a simple person?

-- Phosphorylated serine?

I tried the phosphorylated serine last night and I think it helped! What

is

that stuff? I googled it and came up with NOTHING!

Ann s

www.janesjewel.com

..

[Guest guest]

Is it supposed to lower nighttime cortisol? I have a high level of midnight

cortisol that keeps me up. Thanks!

-- Re: Phosphorylated serine?

Phosphorylated serine is a variety of the form of phosphadityl serine.

Phosphadityl Serine has been shown to improve memory and help ACTH function

- thereby aiding in adrenal function.

Phosphadityl-Serine (PS) an endogogenously occurring phospholipid present in

cell membranes, and is the major acidic phospholipid in the brain.

Phosphadityl-Serine has been shown to positively effect neuronal membranes,

cell metabolism, acetycholine, norepinephrine, seratonin and dopamine.

Phosphadityl-Serine has been known to help improve acetylcholine release,

memory, depression, insomnia, stress, and aged related brain changes

Ann wrote:

I tried the phosphorylated serine last night and I think it helped! What is

that stuff? I googled it and came up with NOTHING!

Ann s

www.janesjewel.com

[Guest guest]

It opens cortisolreceptors thus lowering it by allowing your body to

utilize it better. Sometimes it is enough if your daytime cortiosl is

enough for you and just high at night it cn set the rythm right, btu if

it is too high at night due to low daytime cortisol you also need to

take something to inprove your daytime cortisol levels, either Licorice

Root, IUsocort ot HC depending on how low you are inthe daytime.

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

[Guest guest]

I am in the lower range in the morning. Several have thought that the low,

in range reading in the morning might be causing the higher, out of range

nighttime reading. I have some licorice root in the cabinet. How would one

use the stuff for increasing ONLY the morning cortisol? And, is it possible

that undermedicated hypo could cause the whole cortisol imbalance? If I

could get the Armour dosing right, could the cortisol thing go away too?

Just some thoughts. Thanks!

-- Re: Phosphorylated serine?

It opens cortisolreceptors thus lowering it by allowing your body to

utilize it better. Sometimes it is enough if your daytime cortiosl is

enough for you and just high at night it cn set the rythm right, btu if

it is too high at night due to low daytime cortisol you also need to

take something to inprove your daytime cortisol levels, either Licorice

Root, IUsocort ot HC depending on how low you are inthe daytime.

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

[Guest guest]

>>I have some licorice root in the cabinet. How would one

use the stuff for increasing ONLY the morning cortisol? And, is it possible

that undermedicated hypo could cause the whole cortisol imbalance? If I

could get the Armour dosing right, could the cortisol thing go away too? <<

You would need to take the licorice when you first wake up. Yes SOMETIMES when

cortisol is only a tad low, you can correct it by correcting thyroid, the

problem is when it is more than a tad low the thyroid cannot beutilized properly

and it causes more bad symptoms as i only builds in the blood unable to get to

the cells due to low coretisol.

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

[Guest guest]

How much Licorice? Can it be taken on an empty stomach?

-- Re: Phosphorylated serine?

>>I have some licorice root in the cabinet. How would one

use the stuff for increasing ONLY the morning cortisol? And, is it possible

that undermedicated hypo could cause the whole cortisol imbalance? If I

could get the Armour dosing right, could the cortisol thing go away too? <<

You would need to take the licorice when you first wake up. Yes SOMETIMES

when cortisol is only a tad low, you can correct it by correcting thyroid,

the problem is when it is more than a tad low the thyroid cannot beutilized

properly and it causes more bad symptoms as i only builds in the blood

unable to get to the cells due to low coretisol.

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

[Guest guest]

>>How much Licorice? Can it be taken on an empty stomach? <<

Follow the dorections for dosing what ever product you buy, and I would try to

eat wiht it as well.

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

[Guest guest]

When I went to this link on: Phosphatidyl

<http://www.nextag.com/phosphatidyl-serine-complex/search-html> Serine in

wikipedia it seems quite different from the link you posted.

<http://groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/message/28761;

_ylc=X3oDMTJzdnVubDVkBF9TAzk3MzU5NzE1BGdycElkAzE3MjI5NjkyBGdycHNwSWQDMTcwOTI

1MTA4MgRtc2dJZAMyODc2MQRzZWMDZG1zZwRzbGsDdm1zZwRzdGltZQMxMTk0NDUxODcw> Re:

Phosphorylated serine?

Posted by: " MsSquarepants "

<mailto:ms.squarepants@...?Subject=%20Re%3A%20Phosphorylated%20serine%

3F> ms.squarepants@... <http://profiles.yahoo.com/croberts_01>

croberts_01

Wed Nov 7, 2007 7:43 am (PST)

<http://en.wikipedia.org/wiki/Phosphorylation>

http://en.wikipedia.org/wiki/Phosphorylation

though what this site had to say about phosphorylation was VERY interesting,

especially the part about the P53 tumor suppression protein this involves...

I have a pituitary tumor, but I also have all these small tumors on my body,

and many new ones in the last year or so, the last time, some years ago,

that I asked a doc about them, they said not to worry just normal " fatty "

tumors..

But WHY??? Is my body making them??? Something must cause them??

This P53 also or the upset of it, is the reason for cancer tumors....

SeaLady

[Guest guest]

Which one do I want to take? I have the one I questioned about.

-- Re: Re: Phosphorylated serine?

Check the different spelling on the two items, not the same thing.

Mo

[Guest guest]

You want the one in the subject line. " Phosphatidyl serine is a

similar-sounding nutritional product that has very different uses. "

from Dr. Shames' Feeling Fat, Fuzzy, or Frazzled?

He recommends SeriPhos brand, 1000 mg, to be taken an hour before your

high cortisol time.

Barb

[Guest guest]

I am ready to order some. Is this the one you are referring to Barb?:

http://www.vitacost.com/InterPlexusSeriphos?csrc=PPCADWLT-seriphos & s_kwcid=s

eriphos|462153431

It came up when I googled what you wrote and it looks pretty good.

Cheri

Re: Phosphorylated serine?

You want the one in the subject line. " Phosphatidyl serine is a

similar-sounding nutritional product that has very different uses. "

from Dr. Shames' Feeling Fat, Fuzzy, or Frazzled?

He recommends SeriPhos brand, 1000 mg, to be taken an hour before your

high cortisol time.

Barb

.

[Guest guest]

That's what I have! It says Seriphos on the bottle. My D.O. Wasn't stupid

after all!!! LOL!

-- Re: Phosphorylated serine?

You want the one in the subject line. " Phosphatidyl serine is a

similar-sounding nutritional product that has very different uses. "

from Dr. Shames' Feeling Fat, Fuzzy, or Frazzled?

He recommends SeriPhos brand, 1000 mg, to be taken an hour before your

high cortisol time.

Barb

[Guest guest]

Here is a pretty good explanation explaining phosphorylated serine,

phosphoserine and Seriphos..they DO seem to be connected, previously I had

bought plain phosphoserine, perhaps this works better???

I also did not know how to take it, there were no real instructions for

helping tamp down cortisol levels - according to the info below - it should

be taken during the day to help high late night cortisol and provide help

with sleep.

<http://us.st11.yimg.com/us.st.yimg.com/I/yhst-70115233409875_1969_14437136>

Click to enlarge

InterPlexus Seriphos Adaptogen & Adrenal Support 100 Capsules

Phosphorylated Serine (Phosphoserine) Adaptogen & Adrenal Support* DIETARY

SUPPLEMENT

Basic Chemistry

Phosphatidyl Serine when consumed in food, for example egg yolks, or in a

capsule provides about 20% of active Phosphorylated Serine (see #4 in

Diagram 1). Each 100mg of Phosphatidyl Serine yields about 20mg of active

phosphorylated serine following consumption. The bulk of the weight is

derived from 2 fatty acids, R1 & R2.

In the intestinal tract, the various enzymes (brush border and pancreatic)

clip off the fatty acids, predominantly the unsaturated fatty acids. These

fatty acids are not reassembled in the body to the stump molecule, rather

different fatty acids are attached by the body to replace R1 and R2.

The shaded glycerol molecule is very abundant in the body because it is

found in all body fat and in dietary fats/oils in great abundance.

In brief, the Phosphatidyl Serine acts as a precursor molecule and is not

the active form of this nutrient. In our tissues, the rate limiting step is

the phosphorylation of the serine molecule.

In contrast, Phosphorylated Serine (brand name, SERIPHOSR) provides the

activated or Phosphorylated Serine in a chelate form of magnesium and

calcium.

In the local tissue, the Phosphorylated Serine is linked to glycerol and the

appropriate fatty acids specific to each tissue, and is not linked to the

fatty acids provided in the precursor Phosphatidyl Serine.

Phosphorylated Serine (brand name, SERIPHOSR) is a pure product not derived

from animal tissue. The serine is from vegetable sources and the phosphate

is from a pure phosphate donor compound.

Excerpts & Abstracts on the Use of Phosphorylated Serine

Early Cortisol Escape Phenomenon Reversed by Phophatidyl Serine In Elderly

Normal Subjects. Nerozzi, Dina et al, Clincal Trials Journal, 1-89, vol 26

(1).

Summary

The early cortisol escape phenomenon observed after administration of 1mg of

dexamethasone in 50% of the elderly subjects in the study was reversed by

two months therapy with Phosphatidyl Serine (PS), 3 x 100mg tablets daily.

An action of the compound at the neurotransmitter level is hypothesized.

A number of alterations of the *HPAA was detectable in our study in normal

elderly subjects; abnormal elevation of basal morning cortisol values (3

subjects); disruption of the circadian cortisol pattern (4 subjects); early

cortisol escape phenomenon observed in seven of our subjects. A true

non-suppression was visible only in two individuals. Therefore, the early

cortisol escape phenomenon appears to be the most consistent abnormality

found in our subjects.

The question of contribution of non-specific stress factors to cortisol

hypersecretion obviously cannot be ruled out. However, in our opinion, an

intrinsic neuro-endocrine disturbance, which may be part of a central

dysfunction associated with aging, could be at the root of a substantial

part of the hypersecretion.

According to the membrane hypothesis of aging (1), age-dependent changes of

the membranes can negatively interfere with trophism of the neurons, with

cell to cell communication and ultimately with neurotransmission and thus

with most functions linked to neurotransmission, including hormonal

secretion.

*HPAA: Hypothalmic Pituitary Adrenal Axis

According to Massarotti (2), PS seems to stimulate some sort of

morphogenetic neuronal plasticity, which acts as a compensatory adaptive

mechanism to cell deterioration, and is capable of preventing or delaying

the age dependent decline of neurotransmitter function. On the basis of our

findings we can speculate that existence of an analogous mechanism which

acts on neurotransmission similar to that observed in animals treated with

PS.

However, when we consider the impairment of HPAA as a marker of a more

central neurotransmitter imbalance, we can suppose that the readjustment of

such an altered parameter, although partial, may be brought about by some

action at the neurotransmitter level.

Sund & Sun, Top. Geront., 1979; 15:34-53. Massarotti. M. In: Bes A, ed.

Senile Dementias. Effects of Phosphatidyl Serine in Age Associated Memory

Impairment T.H. Crook. Ph.D.; J. Tinklenberg. MD; J. Yesavage, MD; W.

Petrie, ML); M.G. Nunzi, Ph.D; and D.C. Massari, Ph.D.; Neurology, 1991;

41:611-649.

Summary We treated 149 patients meeting criteria of age associated memory

impairment (AAMI) for 12 weeks with a formulation of Phosphatidyl Serine

(100-150mg PS bid) or placebo.

Patients treated with the compound improved, relative to those untreated,

with learning and memory tasks of daily life.

Analysis of clinical subgroup suggested that persons within the sample who

performed at a relatively low level prior to treatment were most likely to

respond to PS. Within this subgroup, there was improvement on both

computerized and standard neuropsychological performance tests, and also on

clinical global ratings of improvement. The results suggest that the

compound may be a promising candidate for treating memory loss in later

life.

Ingredients

Proprietary Blend: Phosphoserine and Ethanolamine 1,000 mg

Other ingredients: Gelatin.

Suggested usage:

Like all macro minerals, it is best absorbed when taken before meals or

before bedtime at least 15 minutes before eating. For stress, take one

capsule at least 15 minutes before eating.

NOTE: Seriphos works with the pineal gland. Take two in the morning and two

at lunch time before meals for better sleep at nighttime. This mimics the

cortisol " curve " .

Top of Form

Availability: Usually ships in 2-3 business days

seriphospad$21.70pad

Bottom of Form

***SPEND $75 OR MORE AND REGULAR SHIPPING IS FREE!***

Thank you for visiting our store. We strive to meet your needs and if there

is anything we can do to make this a more effective experience, please let

us know. We are committed to providing the absolute best quality products

along with the best in customer service.

SeaLady

[Guest guest]

That is what I have and I think it is working.

-- Re: Phosphorylated serine?

You want the one in the subject line. " Phosphatidyl serine is a

similar-sounding nutritional product that has very different uses. "

from Dr. Shames' Feeling Fat, Fuzzy, or Frazzled?

He recommends SeriPhos brand, 1000 mg, to be taken an hour before your

high cortisol time.

Barb

..

[Guest guest]

Like all macro minerals, it is best absorbed when taken before meals or

Before bedtime at least 15 minutes before eating. For stress, take one

Capsule at least 15 minutes before eating.

NOTE: Seriphos works with the pineal gland. Take two in the morning and two

At lunch time before meals for better sleep at nighttime. This mimics the

Cortisol " curve " .

I am wondering about this part of it. I have been taking it with dinner.

Any thoughts? It does seem to be helping at night. I am afraid that if I

took it during the day it would lower my daytime cortisol and make me

rebound at night like the magnolia extract has done to me in the past. TIA!

-- Re: Phosphorylated serine?

Here is a pretty good explanation explaining phosphorylated serine,

phosphoserine and Seriphos..they DO seem to be connected, previously I had

bought plain phosphoserine, perhaps this works better???

I also did not know how to take it, there were no real instructions for

helping tamp down cortisol levels - according to the info below - it should

be taken during the day to help high late night cortisol and provide help

with sleep.

<http://us.st11.yimg.com/us.st.yimg.com/I/yhst-70115233409875_1969_14437136>

Click to enlarge

InterPlexus Seriphos Adaptogen & Adrenal Support 100 Capsules

Phosphorylated Serine (Phosphoserine) Adaptogen & Adrenal Support* DIETARY

SUPPLEMENT

Basic Chemistry

Phosphatidyl Serine when consumed in food, for example egg yolks, or in a

capsule provides about 20% of active Phosphorylated Serine (see #4 in

Diagram 1). Each 100mg of Phosphatidyl Serine yields about 20mg of active

phosphorylated serine following consumption. The bulk of the weight is

derived from 2 fatty acids, R1 & R2.

In the intestinal tract, the various enzymes (brush border and pancreatic)

clip off the fatty acids, predominantly the unsaturated fatty acids. These

fatty acids are not reassembled in the body to the stump molecule, rather

different fatty acids are attached by the body to replace R1 and R2.

The shaded glycerol molecule is very abundant in the body because it is

found in all body fat and in dietary fats/oils in great abundance.

In brief, the Phosphatidyl Serine acts as a precursor molecule and is not

the active form of this nutrient. In our tissues, the rate limiting step is

the phosphorylation of the serine molecule.

In contrast, Phosphorylated Serine (brand name, SERIPHOSR) provides the

activated or Phosphorylated Serine in a chelate form of magnesium and

calcium.

In the local tissue, the Phosphorylated Serine is linked to glycerol and the

appropriate fatty acids specific to each tissue, and is not linked to the

fatty acids provided in the precursor Phosphatidyl Serine.

Phosphorylated Serine (brand name, SERIPHOSR) is a pure product not derived

from animal tissue. The serine is from vegetable sources and the phosphate

is from a pure phosphate donor compound.

Excerpts & Abstracts on the Use of Phosphorylated Serine

Early Cortisol Escape Phenomenon Reversed by Phophatidyl Serine In Elderly

Normal Subjects. Nerozzi, Dina et al, Clincal Trials Journal, 1-89, vol 26

(1).

Summary

The early cortisol escape phenomenon observed after administration of 1mg of

dexamethasone in 50% of the elderly subjects in the study was reversed by

two months therapy with Phosphatidyl Serine (PS), 3 x 100mg tablets daily.

An action of the compound at the neurotransmitter level is hypothesized.

A number of alterations of the *HPAA was detectable in our study in normal

elderly subjects; abnormal elevation of basal morning cortisol values (3

subjects); disruption of the circadian cortisol pattern (4 subjects); early

cortisol escape phenomenon observed in seven of our subjects. A true

non-suppression was visible only in two individuals. Therefore, the early

cortisol escape phenomenon appears to be the most consistent abnormality

found in our subjects.

The question of contribution of non-specific stress factors to cortisol

hypersecretion obviously cannot be ruled out. However, in our opinion, an

intrinsic neuro-endocrine disturbance, which may be part of a central

dysfunction associated with aging, could be at the root of a substantial

part of the hypersecretion.

According to the membrane hypothesis of aging (1), age-dependent changes of

the membranes can negatively interfere with trophism of the neurons, with

cell to cell communication and ultimately with neurotransmission and thus

with most functions linked to neurotransmission, including hormonal

secretion.

*HPAA: Hypothalmic Pituitary Adrenal Axis

According to Massarotti (2), PS seems to stimulate some sort of

morphogenetic neuronal plasticity, which acts as a compensatory adaptive

mechanism to cell deterioration, and is capable of preventing or delaying

the age dependent decline of neurotransmitter function. On the basis of our

findings we can speculate that existence of an analogous mechanism which

acts on neurotransmission similar to that observed in animals treated with

PS.

However, when we consider the impairment of HPAA as a marker of a more

central neurotransmitter imbalance, we can suppose that the readjustment of

such an altered parameter, although partial, may be brought about by some

action at the neurotransmitter level.

Sund & Sun, Top. Geront., 1979; 15:34-53. Massarotti. M. In: Bes A, ed.

Senile Dementias. Effects of Phosphatidyl Serine in Age Associated Memory

Impairment T.H. Crook. Ph.D.; J. Tinklenberg. MD; J. Yesavage, MD; W.

Petrie, ML); M.G. Nunzi, Ph.D; and D.C. Massari, Ph.D.; Neurology, 1991;

41:611-649.

Summary We treated 149 patients meeting criteria of age associated memory

impairment (AAMI) for 12 weeks with a formulation of Phosphatidyl Serine

(100-150mg PS bid) or placebo.

Patients treated with the compound improved, relative to those untreated,

with learning and memory tasks of daily life.

Analysis of clinical subgroup suggested that persons within the sample who

performed at a relatively low level prior to treatment were most likely to

respond to PS. Within this subgroup, there was improvement on both

computerized and standard neuropsychological performance tests, and also on

clinical global ratings of improvement. The results suggest that the

compound may be a promising candidate for treating memory loss in later

life.

Ingredients

Proprietary Blend: Phosphoserine and Ethanolamine 1,000 mg

Other ingredients: Gelatin.

Suggested usage:

Like all macro minerals, it is best absorbed when taken before meals or

before bedtime at least 15 minutes before eating. For stress, take one

capsule at least 15 minutes before eating.

NOTE: Seriphos works with the pineal gland. Take two in the morning and two

at lunch time before meals for better sleep at nighttime. This mimics the

cortisol " curve " .

Top of Form

Availability: Usually ships in 2-3 business days

seriphospad$21.70pad

Bottom of Form

***SPEND $75 OR MORE AND REGULAR SHIPPING IS FREE!***

Thank you for visiting our store. We strive to meet your needs and if there

is anything we can do to make this a more effective experience, please let

us know. We are committed to providing the absolute best quality products

along with the best in customer service.

SeaLady

[Guest guest]

>

> I am ready to order some. Is this the one you are referring to Barb?:

> http://www.vitacost.com/InterPlexusSeriphos?csrc=PPCADWLT-

seriphos & s_kwcid=s

> eriphos|462153431

>

Ann said that's what she has, so that must be it. But I thought you

had low cortisol, not high?

Barb

[Guest guest]

I think it depends on each person's adrenal state. I am similar to you. For

me, I would assume I do not want to take it during the day since my cortisol

is already low and I do not want to lower it further. At night my cortisol

is high so taking it an hour before bed like I have read on some sites makes

more sense for me.

Cheri

Re: Phosphorylated serine?

Here is a pretty good explanation explaining phosphorylated serine,

phosphoserine and Seriphos..they DO seem to be connected, previously I had

bought plain phosphoserine, perhaps this works better???

I also did not know how to take it, there were no real instructions for

helping tamp down cortisol levels - according to the info below - it

should

be taken during the day to help high late night cortisol and provide help

with sleep.

<http://us.st11.yimg.com/us.st.yimg.com/I/yhst-70115233409875_1969_14437136>

Click to enlarge

InterPlexus Seriphos Adaptogen & Adrenal Support 100 Capsules

Phosphorylated Serine (Phosphoserine) Adaptogen & Adrenal Support* DIETARY

SUPPLEMENT

Basic Chemistry

Phosphatidyl Serine when consumed in food, for example egg yolks, or in a

capsule provides about 20% of active Phosphorylated Serine (see #4 in

Diagram 1). Each 100mg of Phosphatidyl Serine yields about 20mg of active

phosphorylated serine following consumption. The bulk of the weight is

derived from 2 fatty acids, R1 & R2.

In the intestinal tract, the various enzymes (brush border and pancreatic)

clip off the fatty acids, predominantly the unsaturated fatty acids. These

fatty acids are not reassembled in the body to the stump molecule, rather

different fatty acids are attached by the body to replace R1 and R2.

The shaded glycerol molecule is very abundant in the body because it is

found in all body fat and in dietary fats/oils in great abundance.

In brief, the Phosphatidyl Serine acts as a precursor molecule and is not

the active form of this nutrient. In our tissues, the rate limiting step

is

the phosphorylation of the serine molecule.

In contrast, Phosphorylated Serine (brand name, SERIPHOSR) provides the

activated or Phosphorylated Serine in a chelate form of magnesium and

calcium.

In the local tissue, the Phosphorylated Serine is linked to glycerol and

the

appropriate fatty acids specific to each tissue, and is not linked to the

fatty acids provided in the precursor Phosphatidyl Serine.

Phosphorylated Serine (brand name, SERIPHOSR) is a pure product not

derived

from animal tissue. The serine is from vegetable sources and the phosphate

is from a pure phosphate donor compound.

Excerpts & Abstracts on the Use of Phosphorylated Serine

Early Cortisol Escape Phenomenon Reversed by Phophatidyl Serine In Elderly

Normal Subjects. Nerozzi, Dina et al, Clincal Trials Journal, 1-89, vol 26

(1).

Summary

The early cortisol escape phenomenon observed after administration of 1mg

of

dexamethasone in 50% of the elderly subjects in the study was reversed by

two months therapy with Phosphatidyl Serine (PS), 3 x 100mg tablets daily.

An action of the compound at the neurotransmitter level is hypothesized.

A number of alterations of the *HPAA was detectable in our study in normal

elderly subjects; abnormal elevation of basal morning cortisol values (3

subjects); disruption of the circadian cortisol pattern (4 subjects);

early

cortisol escape phenomenon observed in seven of our subjects. A true

non-suppression was visible only in two individuals. Therefore, the early

cortisol escape phenomenon appears to be the most consistent abnormality

found in our subjects.

The question of contribution of non-specific stress factors to cortisol

hypersecretion obviously cannot be ruled out. However, in our opinion, an

intrinsic neuro-endocrine disturbance, which may be part of a central

dysfunction associated with aging, could be at the root of a substantial

part of the hypersecretion.

According to the membrane hypothesis of aging (1), age-dependent changes

of

the membranes can negatively interfere with trophism of the neurons, with

cell to cell communication and ultimately with neurotransmission and thus

with most functions linked to neurotransmission, including hormonal

secretion.

*HPAA: Hypothalmic Pituitary Adrenal Axis

According to Massarotti (2), PS seems to stimulate some sort of

morphogenetic neuronal plasticity, which acts as a compensatory adaptive

mechanism to cell deterioration, and is capable of preventing or delaying

the age dependent decline of neurotransmitter function. On the basis of

our

findings we can speculate that existence of an analogous mechanism which

acts on neurotransmission similar to that observed in animals treated with

PS.

However, when we consider the impairment of HPAA as a marker of a more

central neurotransmitter imbalance, we can suppose that the readjustment

of

such an altered parameter, although partial, may be brought about by some

action at the neurotransmitter level.

Sund & Sun, Top. Geront., 1979; 15:34-53. Massarotti. M. In: Bes A, ed.

Senile Dementias. Effects of Phosphatidyl Serine in Age Associated Memory

Impairment T.H. Crook. Ph.D.; J. Tinklenberg. MD; J. Yesavage, MD; W.

Petrie, ML); M.G. Nunzi, Ph.D; and D.C. Massari, Ph.D.; Neurology, 1991;

41:611-649.

Summary We treated 149 patients meeting criteria of age associated memory

impairment (AAMI) for 12 weeks with a formulation of Phosphatidyl Serine

(100-150mg PS bid) or placebo.

Patients treated with the compound improved, relative to those untreated,

with learning and memory tasks of daily life.

Analysis of clinical subgroup suggested that persons within the sample who

performed at a relatively low level prior to treatment were most likely to

respond to PS. Within this subgroup, there was improvement on both

computerized and standard neuropsychological performance tests, and also

on

clinical global ratings of improvement. The results suggest that the

compound may be a promising candidate for treating memory loss in later

life.

Ingredients

Proprietary Blend: Phosphoserine and Ethanolamine 1,000 mg

Other ingredients: Gelatin.

Suggested usage:

Like all macro minerals, it is best absorbed when taken before meals or

before bedtime at least 15 minutes before eating. For stress, take one

capsule at least 15 minutes before eating.

NOTE: Seriphos works with the pineal gland. Take two in the morning and

two

at lunch time before meals for better sleep at nighttime. This mimics the

cortisol " curve " .

Top of Form

Availability: Usually ships in 2-3 business days

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SeaLady

[Guest guest]

I have low cortisol during the day and very high at night during my sleep

hours. Val has said this might be good for people who have high cortisol at

night so it is worth a try. I know I can't do the Relora type products but

reading on this it seems more balancing than just to lower so I would have

to test it and see what kind of reaction I have.

Cheri

Re: Phosphorylated serine?

>

Ann said that's what she has, so that must be it. But I thought you

had low cortisol, not high?

Barb

.

[Guest guest]

I have slightly low, in range in the morning. It stays in range during the

day and goes too high at the midnight reading, out of range and I do not

sleep

-- Re: Phosphorylated serine?

>

> I am ready to order some. Is this the one you are referring to Barb?:

> http://www.vitacost.com/InterPlexusSeriphos?csrc=PPCADWLT-

seriphos & s_kwcid=s

> eriphos|462153431

>

Ann said that's what she has, so that must be it. But I thought you

had low cortisol, not high?

Barb

[Guest guest]

Cheri,

What are the symptoms of high cortisol at night?

Tina

>

> I have low cortisol during the day and very high at night during my

sleep

> hours. Val has said this might be good for people who have high

cortisol at

> night so it is worth a try. I know I can't do the Relora type

products but

> reading on this it seems more balancing than just to lower so I

would have

> to test it and see what kind of reaction I have.

>

> Cheri

> Re: Phosphorylated serine?

>

>

>

>

> >

> Ann said that's what she has, so that must be it. But I thought

you

> had low cortisol, not high?

>

> Barb

>

>

> .

>

>

>

>

[Guest guest]

My saliva tests showed that I was super high the first thing in the morning

and the lab report said it was from a hypocortisol state at night and that I

need to follow a low glycemic diet (which I already was) and that I need to

address insomnia.

Easier said than done, lol. I have had sleep issues since childhood.

The only symptom I noticed was sleeping issues. Other than that I have no

idea what high cortisol symptoms during sleep hours are, other than your

early morning cortisol will be off the charts which mine was.

Cheri

Re: Phosphorylated serine?

Cheri,

What are the symptoms of high cortisol at night?

Tina

[Guest guest]

Cheri have you ever been checked for Sleep Apnea?

--

Artistic Grooming- Hurricane WV

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/