Guest guest Posted February 13, 2001 Report Share Posted February 13, 2001 I wrote a week or so ago about our experience with inhaled gentamicin. For those who missed it, Rina (dF508/W1282X) has been on inhaled gent. for about a year. She was on inhaled colymicin following aggressive treatment for first growth Pseudomonas aeruginosa in the summer of 1999. As soon as the latest research on " stop " mutations was reported following trials in Israel, we asked the cf team to switch to gent. We give her inhaled gent. twice per day, following morning and evening physio. We mix one ml. of Garamycin (brand name for IV gent.) with three ml. normal saline. The concentration is 40 mg. per ml. so she gets a total of 80 mg. per day. We use a Pari Pro Turbo with a Sidestream nebulizer - it takes about ten minutes to deliver. We have had no problems and Rina's lungs have been in great shape. She usually cultures normal flora, occassionaly light growth of Staph. aureus. The theory is that by suppressing the " nonsense " stop codon, gentamicin promotes the production of some functional CFTR. Is it working? I don't know. Would Rina be culturing something without the inhaled gent.? I am not sure and I have no intention of finding out, LOL. Max, father of four, one wcf Quote Link to comment Share on other sites More sharing options...
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