Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 I think what is needed is research on general genetics and inheriting recessive genes (for anyone still confused) - all the CF info pretty much just talks about getting the disease (two carriers getting together) it isn't too concerned with how carriers (with a none carrier partner) keep passing on one mutation. That might help clarify it for everyone. Here are some resources: (following is an excerpt from link listed below.) " IF ONLY ONE PARENT IS A CARRIER, however, the odds of course change accordingly. _____D____r_ D__D/D__D/r_ D__D/D__D/r_ NO affected children CAN be produced, as the unaffected parent's genes dominate over those of the recessive condition, but the children still have a 50/50 chance of being CARRIERS or not. As no sibling is affected, however, this sometimes leads to misunderstanding of one's CARRIER status, which might unfortunately lead to a marriage with another CARRIER which will then reproduce the above risks of unfortunate outcomes for the children of that union, with each having a 25% chance of DEMONSTRATING the condition from receiving both recessive genes at conception as described above. " excerpt from this link: http://neuro-www.mgh.harvard.edu/forum/GeneralNeurologyF/2.4.986.28PMGenetic sBasics.htm This link is actually about dog breeding, but it shows a chart of how recessive genes get passed along by carriers potentially mating with none carriers. http://www.essfta.org/recessive.htm Hope these links help clarify things a little. Lori Re: geneticsresponse > Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my > research gives me what I have posted or I wouldn't have posted. Solid > information > to the contrary will be welcomed and accepted and reposted. > n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom > exhausted! > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 I am getting lost in all of this. I do not know what anybody is saying anymore. Genetics. This is a very complicated subject overall, but in the case of heredity of CF genes, it is extremely simple. There is only one gene that contributes to the disease, much in the way a person has hanging or attached earlobes. Because we each have two sets of genes, that one gene is actually two... kinda like a pair of shoes. Each of your parents sets a shoe in front of you. Neither knows whether the other, or even themselves has a left shoe or a right shoe. If they match up correctly in the way they are set in front of you, then you get to wear the shoes. they both put two left shoes down.......NO they both put two right shoes down.....NO they put opposite shoes down, but the right is on the left and the left is on the right......NO they put opposite shoes down and they are on the right side....YES, you have shoes! There is a bonus, though. If you got two of the same shoe, you get to carry them around with you, even if you cannot wear them! Soon, you will have a child to give shoes to! Now perfect, but a good analogy. The carrier of the shoes only has one of the two shoes that could match with another shoe. Only one of the two. This shoe could be passed down from generation to generation and never find its match until one day somebody is blindsided and suddenly has to wear shoes! Stupid shoes! Anyways, for a child to be born with CF, both parents have to be carriers. Odds, as mentioned in previous messages are 1 in 4 to have CF, 2 in four to carry a CF gene, 1 in 4 to not carry at all. A carrier could have had the CF gene that they carry passed down from a single nomad eeking out a living picking berries and fishing the Elbe River thousands of years ago. Only one mutated CF gene is all it takes to be propogated through generations, father to son, mother to daughter, undetected and harmless. Just the way it is. A carrier only has one gene. Only one parent, of each generation need be a carrier for the mutated gene to be passed down through the generations. Forgive me if I do not cite any sources, but I believe that I have learned enough of genetics in the past four years of study that I do not need to cite sources. I am a reliable source myself. Rich Re: geneticsresponse Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my research gives me what I have posted or I wouldn't have posted. Solid information to the contrary will be welcomed and accepted and reposted. n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom exhausted! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 Sehr gut Lori. Very clear and concise. Re: geneticsresponse > Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my > research gives me what I have posted or I wouldn't have posted. Solid > information > to the contrary will be welcomed and accepted and reposted. > n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom > exhausted! > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 And I do not mean only one gene type!!! Re: geneticsresponse Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my research gives me what I have posted or I wouldn't have posted. Solid information to the contrary will be welcomed and accepted and reposted. n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom exhausted! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 Gosh, n sure knows how to generate some emails, huh! Re: geneticsresponse > > > > Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All > my > > research gives me what I have posted or I wouldn't have posted. Solid > > information > > to the contrary will be welcomed and accepted and reposted. > > n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom > > exhausted! > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 YOUR response is hysteral..so very refreshing too. HAHAHAHA:):) THANKS LOVE & HUGS, grandmomBEV Re: geneticsresponse I am getting lost in all of this. I do not know what anybody is saying anymore. Genetics. This is a very complicated subject overall, but in the case of heredity of CF genes, it is extremely simple. There is only one gene that contributes to the disease, much in the way a person has hanging or attached earlobes. Because we each have two sets of genes, that one gene is actually two... kinda like a pair of shoes. Each of your parents sets a shoe in front of you. Neither knows whether the other, or even themselves has a left shoe or a right shoe. If they match up correctly in the way they are set in front of you, then you get to wear the shoes. they both put two left shoes down.......NO they both put two right shoes down.....NO they put opposite shoes down, but the right is on the left and the left is on the right......NO they put opposite shoes down and they are on the right side....YES, you have shoes! There is a bonus, though. If you got two of the same shoe, you get to carry them around with you, even if you cannot wear them! Soon, you will have a child to give shoes to! Now perfect, but a good analogy. The carrier of the shoes only has one of the two shoes that could match with another shoe. Only one of the two. This shoe could be passed down from generation to generation and never find its match until one day somebody is blindsided and suddenly has to wear shoes! Stupid shoes! Anyways, for a child to be born with CF, both parents have to be carriers. Odds, as mentioned in previous messages are 1 in 4 to have CF, 2 in four to carry a CF gene, 1 in 4 to not carry at all. A carrier could have had the CF gene that they carry passed down from a single nomad eeking out a living picking berries and fishing the Elbe River thousands of years ago. Only one mutated CF gene is all it takes to be propogated through generations, father to son, mother to daughter, undetected and harmless. Just the way it is. A carrier only has one gene. Only one parent, of each generation need be a carrier for the mutated gene to be passed down through the generations. Forgive me if I do not cite any sources, but I believe that I have learned enough of genetics in the past four years of study that I do not need to cite sources. I am a reliable source myself. Rich Re: geneticsresponse Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my research gives me what I have posted or I wouldn't have posted. Solid information to the contrary will be welcomed and accepted and reposted. n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom exhausted! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2001 Report Share Posted January 12, 2001 Rich, Good post. I always believed that only one needed to be a carrier to pass on the carrier gene, As I mentioned before my sister-in-law carriers cf , her husband doesn't but there daughter is also a f5108 carrier, like her mother. Re: geneticsresponse > > > Call your local Cystic Fibrosis Group, Foundation, Society, or Trust. All my > research gives me what I have posted or I wouldn't have posted. Solid > information > to the contrary will be welcomed and accepted and reposted. > n Rojas vwc, mom of 3, 1 w cf, " kids " grown and doing well, Mom > exhausted! > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2001 Report Share Posted January 13, 2001 So is " sehr gut " a good thing? : ) Lori Re: geneticsresponse > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2001 Report Share Posted January 13, 2001 I think this is what I said and we agree on this point - just worded it differently. 75% chance of NOT getting CF (50% chance on being a carrier with one mutation from father OR mother, 25% chance of not getting a mutation from either parent so not even being a carrier), 25% chance of getting CF (a mutation from each parent). I think I am done now - everyone else??? Lori Re: geneticsresponse > Lori, not quite; the odds if two carriers have a pregnancy are for two, not > one > carrier, one naiether, and one cf, but these are only odds. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2001 Report Share Posted January 13, 2001 Lori, you got it, too! n Rojas Quote Link to comment Share on other sites More sharing options...
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