Dr Cecile Jadin RA Protocol

[Guest guest]

Note: The US has no significant ability to detect Rickettsia.

Australian results have about 90% of RA/CFIDS patients with one of

the three families of CWD bacteria found. Her protocol treats ALL of

these families.... Nicolson has published that the number of

different species increases with the length of illness. Hence,

multiple infections should be assumed.

From http://www.cfs.inform.dk/Nyheder.udland/cfsnews19aug.txt

THE RICKETTSIAL APPROACH IN TREATMENT OF PATIENTS FOR CFS, FM, RA.

and NEUROLOGICAL DYSFUNCTION

Dr Cecile Jadin MD MBBCH.

P.O. Box 4417 Randburg 2125

South Africa

Cecile, originally from Belgium, a surgeon by profession, is now

working in South Africa as a clinician. For the last 7 years, she has

focused her research on Rickettsia. Her father, Professor JB Jadin,

undertook groundbreaking research on Rickettsial infection, first in

the

Pasteur Institute of Tunisia, then in Central Africa with Professor

Giroud. From an early age she was familiar with the work of her

father and

colleagues. What she presented, therefore were the results of teamwork

from the last 100 years.

Eight years ago, one of her friends became unable to walk and was

diagnosed as having CFS. For 4 years Cecile suggested the diagnosis

of Rickettsial infection. The Weil-Felix test was performed several

times in South Africa and the results were negative. 4 years

ago her friend came to her with an acute appendicitis. She removed

her appendix, and upon her request, she sent her serum to her father

to test for Rickettsia, via the Giroud's Micro-Agglutination testing

and it was positive. Cecile treated her with Tetracyclines and 3

weeks later, she was riding her horse again. Cecile admitted she

herself was sceptical. But this case brought her a couple of 100

patients and the publicity surrounding an investigation of her

methodology by the South African Medical Council brought several

thousand more.

Rickettsiae, like mycoplasma, are infections that are half way

between bacteria and virus and they infect inside cells. Because they

are

related to bacteria, they are sensitive to antibiotics. The most well

known is the strain R. Prowaseki which causes epidemic Typhus. Some

strains are known to be capable of causing non-obvious infections

which

lead to symptoms under certain conditions.

Rickettsial-like organism could be involved in some CFS patients for

many reasons because (to name a few):

1. Onset is acute in many cases, with a flu like illness, but

illness continues (Rickettsiae can infect then remain dormant

until something activates them)

2. The epidemic and non epidemic cases could highlight the life of

a germ emerging and disappearing in a wave pattern,

epidemically and historically. The survival of the germ being

circumstance dependent - other factors are maybe needed to

maintain itself in a particular host.

3. Lymphocyte studies conducted on sheep with tick-borne diseases,

CFS patients, and patients with Q Fever endocarditis are

showing amazingly similar results.

4. During the First World War, 25 million Russians contracted

louse-borne epidemic typhus, resulting in 3 million deaths. Why

not

before or after? It could suggest that the stress factor

reactivates

the virulence. In the medical history of CFS patients, stress

has

often been described as the start of the illness.

5. The symptoms displayed by CFS, Fibromyalgia, RA, and even

neurological patients like MS, show the same diversity of

symptoms as known Rickettsial patients.

6. The success rate of the Rickettsia treatment, Tetracycline. Dr

e Bottero on 100 patients, Dr Tableton on 300

patients and herself on a much larger number of patients

- 3,800. Patients maintain an 84% - to 96% recovery rate.

Three Cornerstones of Diagnosing Chronic Rickettsia Infection:

1. By Giroud's Micro-Agglutination test against five strains of

Rickettsia: R. Prowazeki,R. Mooseri, R. Gonori, ielia

Burnetti, Neo Rickettsia , Chlamydia. Standard Rickettsia tests

are

only for acute infection.[This testing is only available in

France

and South Africa ]

2. Blood tests, most relevant: - Liver Function Tests - Rickettsia

can show hepotoxicity - Iron study - abnormalities sometimes. -

Thyroid antibodies, rather than TFT, although the TFT show

abnormalities in 3% of patients, the thyroid AB are elevated in

28%

of cases and improve or normalise rapidly with treatment. -

CRP, RF,

ANF, WR elevated in 53% cases but improve with treatment

3. Physical Exam Symptoms -tiredness, myalgia, arthralgia,

headaches (retroorbital and temporal), memory and concentration

deficit, psychological and neurological disorders, chest pain,

palpitations, vision abnormalities, nausea, loss of balance,

recurrent sore throat, bruising , sweats, low grade fever,

Raynauds

syndrome. A constant guideline in the Physical examination

shows -

An inflamed throat - Multiple adenopathies - Heart abnormalities

(vascular and valvular impact ) - RIF (right inguinal fascia)

tenderness (ie tenderness of the appendix region )

Treatment of Rickettsia

Treatment consists of 7 to 12 days per month of a specific

Tetracycline used as follows :

1. A high dosage is required 2g/day for about 12 days for the old

tetracyclines and phenicolates with the usual reservations

about chloramphenicol and 300 mg/day for doxycycline and 6

capsules per day for lymecycline(6) with the limitation of:

- Safety Our experience is that when liver functions are

normal to start with, they stay normal. If they were abnormal,

they will improve during treatment and generally return to

normal. Rickettsia are more hepotoxic than Tetracyclines.

- Tolerance a) The gastric intolerance will be successfully

prevented by using a gastric pump inhibitor during and if

necessary before and after the administration of the

Tetracyclines. The tolerance of the treatment is directly

related to the J/Herxheimer reaction, a reactivation of old

symptoms and/or exacerbation of present symptoms that occurs on

antibiotic therapy. Its presence has a very important

diagnostic and

prognostic value. It will fade with the number of treatments

received. When very severe, the H/R is treated with Probenecid.

2. The Tetracyclines are alternated because:

a) A patient is frequently contaminated by many strains of

Rickettsia and different Rickettsia have different

sensitivity to different Tetracyclines.

A patient might build resistance to each Tetracycline.

c) Patients show individual sensitivity to different

Tetracyclines or combinations and is very often a privileged

reaction to a specific treatment.

3. The Tetracyclines are combined with Quinolones, Macrolides or

Metronidazole, because Rickettsia present a wide heterogeneity

of susceptibility of different drugs

4. The treatment is often long due to:

a) The chronicity of the germ

The multiple foci of Rickettsia

c) The fact that Rickettsia have a slow evolution and some foci

are dormant, encapsulated and therefore protected from

antibiotic therapy. Only when they become active can they be

treated.

d) Each treatment will allow the immune system to produce and

maintain a proper and efficient level of antibodies. This

happens each time the antigen Rickettsia are released from

the cell to the blood stream while on antibiotic therapy.

e) The length of the disease should logically imply a lengthy

treatment. In our experience, this point is not always true.

Patients, ill for many years, may recover after a few months

treatment.

5. Adjuvants such as Vitamin B complex and acidobacillus are also

used.

6. Cortisone is avoided as it reactivates the germ .

7. Exercise is recommended, for the following 3 reasons:

- Rickettsia is a vascular disease

- The fact that strains of Rickettsia grow better in vitro when

maintained in a CO2 enriched atmosphere.

- The suggestion that Rickettsia grow best when the metabolism

of the host cell is low .

8. Hot baths - to eliminate toxins produced by Rickettsia when

liberated in the bloodstream .

9. Reinfection may obviously occur. Reactivation (called so,

rather than relapse) may also happen due to the interaction of

bacteria, virus, stress, pollution, etc. causing the Rickettsia

to

change to active from dormant. Treatment Time Treatment is

for 3

months to 2 years - 8 months on average. However, as previously

mentioned, the length of treatment is not directly correlated

to the

length of illness. If symptoms return, treat, keep treating. It

has

also been reported that when patients stop treatment before all

symptoms resolve, they slowly, over the following months, get a

return to their level of symptoms that existed before treatment

began. So treatment must not be stopped until all symptoms

resolve

and a negative testing is obtained. Patients can be divided

into 2

categories: 1. Fast progress - their illness was mainly

Rickettsia

2. Slow progress - their illness was Rickettsia plus other

factors No toxicity has been reported ,after the first 3

months, treatment is generally well tolerated.

References include:

1. Giroud P, et al. Au sujet de maladies rickettsiennes et de

celles aux agents proches en Europe Occidentale. Extrait de

Bulletin des Saances. 1976; 3: 420-430.

2. Giroud P, Jadin J. Conceptions actuelles concernant les

rickettsioses et leurs vaccinations. Ann. Soc. Belge Med.

Trop. 1961;

3. 193-206. 3. Le Gac P. Le traitement de la sclerose en plaques

d'origine rickettsienne et neo-rickettsienne. Compte rendu des

communications consacrees aux rickettsioses et

neo-rickettsioses. 1986.

4. Roca V. Transient acquired immunodeficiency during rickettsial

disease. Arch Intern Med. 1984; 144: 198-99 (letter).

5. Jadin J, et al. Meningite, meningocoques et rickettsioses.

Archs Inst. Pasteur Tunis. 1987; 64(3): 321-325. 6 .Bottero PH.

L'antibiotherapie et ses adjuvants. Compte rendu des

communications

consacrees aux rickettsioses et neo-rickettsioses. 1986.