Fw: [cfs_research] FM, CFS and MPS

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[cfs_research] FM, CFS and MPS

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Jan van Roijen

Help ME Circle, 28 februari 2001

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Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Curr Opin Rheumatol 2001 Mar;13(2):117127

Buskila D

Professor of Medicine, Ben Gurion University of the Negev, Faculty of

Health Sciences, Soroka Medical Center, Beer Sheva, Israel.

PMID: 11224736

The prevalence of chronic widespread pain in the general population in

Israel was comparable with reports from the USA, UK, and Canada.

Comorbidity with fibromyalgia (FM) resulted in somatic hyperalgesia in

patients with irritable bowel syndrome. One sixth of the subjects with

chronic widespread pain in the general population were also found to have

a mental disorder.

Mechanisms involved in referred pain, temporal summation, muscle

hyperalgesia, and muscle pain at rest were attenuated by the

NmethylDaspartate (NMDA) antagonist, ketamine, in FM patients. Delayed

corticotropin release, after interleukin6 administration, in FM was

shown to be consistent with a defect in hypothalamic

corticotropinreleasing hormone neural function. The basal autonomic

state of FM patients was characterized by increased sympathetic and

decreased parasympathetic systems tones.

The severity of functional impairment as assessed by the Medical Outcome

Survey Short Form (SF36) discriminated between patients with widespread

pain alone and FM patients.

Chronic fatigue syndrome (CFS) occurred in about 0.42% of a random

communitybased sample of 28,673 adults in Chicago, Illinois. A

significant clinical overlap between CFS and FM was reported. Cytokine

dysregulation was not found to be a singular or dominant factor in the

pathogenesis of CFS. A favorable outcome of CFS in children was reported;

two thirds recovered and resumed normal activities.

No major therapeutic trials in FM and CFS were reported over the past

year.