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Molecular Medicine MedPulse® www.medscape.com/molecularmedicinehomeMedPulse is a weekly index of key news and features on Medscape's specialty sites compiled by Medscape's Editors.

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Conference Report - Breast Cancer Markers: What Next? Which HER-2/neu assay yields the best results in most clinical settings? Medscape General Medicine 5(4) 2003Molecular Diagnosis of Common STDs Experts at the American Society of Clinical Pathology meeting discuss the best way to screen individuals at high risk for common STDs.Medscape Molecular Medicine 5(2) 2003Diagnostic Usefulness of Monoclonal Antibody P504S in the Workup of Atypical Prostatic Glandular Proliferations In the current prostate-specific antigen screening era, surgical pathologists are faced with increasing numbers of prostate needle biopsy specimens with exceedingly small foci of prostate cancer.Am J Clin Pathol 120(5) 2003

ASK THE EXPERTS ON IRRITABLE BOWEL SYNDROMEAre there any means of identifying slow transit time other than useof radiopaque markers? Find out what expert Yehuda Ringel, MD, hadto say in "Ask the Experts - Measuring Colonic Transit Time." NEW inthe "Focus On" section of the IBS Resource Center.

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Criminalizing Medical Errors: Does the Punishment Fit the Crime? Medical mistakes are increasingly being charged as criminal acts; society's changing attitudes may be to blame, according to a BMJ editorial.Medscape Medical News 2003U.N. Sets Back U.S. Bid for Global Stem Cell Ban A U.N. tradition of seeking broad international consensus in the drafting of treaties has set back a Bush administration campaign for a global ban on medical research on stem cells.Reuters Health Information 2003Pros and Cons of Open-Access Publishing Debated One article argues that all scientific research should be freely and immediately available online, while a counterpoint article warns that many questions must be answered before open-access publishing can be widely implemented.Medscape Medical News 2003Need to Regulate "Dangerous" Research Debated A "spirited" debate on the need to regulate researchers who are involved in "sensitive" research related to potentially dangerous pathogens highlighted a half-day symposium, "National Security and Biological Research: Where Are the Boundaries," held here at the New York Academy of Sciences (NYAS) on Tuesday.Reuters Health Information 2003Enzyme Treatment Permits Axon Regeneration in Severed Nerves Treatment of severed peripheral nerves with proteoglycan-degrading enzymes enhances axon regeneration in mice, according to a report presented at the annual meeting of the Society for Neuroscience in New Orleans.Reuters Health Information 2003Splenocyte Injection Leads to Islet Regeneration in Murine Autoimmune Diabetes In nonobese diabetic (NOD) mice, a model of autoimmune (type 1) diabetes, injections of live donor splenocytes from healthy nondiabetic mice leads to islet cell regeneration and the permanent reversal of disease, even in mice with end-stage diabetes.Reuters Health Information 2003Heart Valves Made With Patient's Own Cells A new type of heart valve made with a patient's own cells may offer an alternative that is safer than other replacement valves, German scientists reported on Wednesday.Reuters Health Information 2003Immunoglobulin Helpful in Inflammatory Cardiopathy Intravenous immunoglobulin appears effective in the treatment of acute inflammatory cardiomyopathy, Japanese researchers report in the October issue of the International Journal of Cardiology.Reuters Health Information 2003Fat Cell Secretions May Explain Link Between Obesity and Hypertension Adipocytes secrete mineralocorticoid-releasing factors that directly stimulate the adrenal gland to release aldosterone, new study findings suggest. Reuters Health Information 2003New Costimulation Blocker May Be Effective for Rheumatoid Arthritis Treatment Investigators also found low rates of serious adverse effects among patients receiving 10 mg CTLA4Ig per kilogram of body weight. Medscape Medical News 2003POMC Gene Expression Cures Diabetes in Mice Increased expression of the propiomelanocortin (POMC) gene by hypothalamic neurons can normalize glucose homeostasis in leptin-deficient diabetic mice, new research indicates.Reuters Health Information 2003Gene Modified Cell Therapy Ameliorates Rheumatoid Arthritis in Animal Model Dendritic cells that express an apoptosis-inducing protein and that target antigen-specific T cells inhibit the development of disease in an animal model of rheumatoid arthritis, researchers at the University of Alabama at Birmingham report.Reuters Health Information 2003Findings Shed Light on How Imiquimod Clears Basal Cell Cancer Topical therapy with imiquimod, a local immune response modifier, promotes the destruction of basal cell carcinoma (BCC) by increasing tumor susceptibility to apoptosis and by attracting immune cells to the tumor site, new research shows.Reuters Health Information 2003

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