Re: minocycline-immune suppresant?

[Guest guest]

Hi and all,

> From: S C <sasc@...>

>

> I would like more information on this. Is it the doctors latest

> explanation for minocycline showing results or is there some

> definite proof and studies to show it.

First I read of an immunosuppressant aspect re. minocycline was in Part

III, chap. 32, of The New Arthritis Breakthrough. Page 280 is one

place in the chapter where it's discussed.

> Lately it appears to me that the AP is being discounted everywhere,

> even here.

I'm not discounting infectious organism. Please don't think that. To

me, it makes " autoimmunity " perfectly logical. Something that has long

been missing in my own small personal world. I have two adult children

presently with autoimmune disorders. One has vitiligo and areata

universalis - since childhood. The other MS. Another adult child had

their large intestine removed several yrs back due to ulcerative

colitis, which was followed by wearing leg braces for 2 years - some

idiot MD in the hospital had ordered her taken off prednisone abruptly,

which lead to osteonecrosis.

I have spent the last 2-1/2 yrs of my life reading about the immune

system. I'm sure you can understand why. So, for me, when I hear

about a treatment (whatever it is) I want to know IF it affects the

immune system and HOW it does so. Whether it's lymphocytes, cytokines,

neurotransmitters/peptides, macrophages, Langerhans cells, etcetera.

" Theoretically " minocycline should work for my " child " with areata.

Calm down a whole lot of the immune system that's involved. But, if I

personally believe that an organism is causing areata, then I have to

ask myself do I *want* to calm it down. For *them* the answer is

NO. For someone with debilitating RA or scleroderma my answer would be

YES. The answer is relative to each person's situation. There's no

right answer for everyone.

Cutting to the quick, I've looked into minocycline, doxycycline and

zithromax so far. Among the 3 the one which seems less likely to

inhibit the immune system is zithromax. I say that because I looked at

its use for people with AIDS - the last people in the world who want

their immune system depressed. I haven't really spent any time looking

into Biaxin but I do know people with AIDS are often Rx'd it.

If you want to read more about minocycline, you can do a PubMed search

with:

minocycline AND lymphocyte

Last month, I found a total of 35 returns with that one query and 12

seemed of interest, including one dated 1977.

Just because tetracyclines, some more than others, have an

immunomodulating factor, doesn't mean their antibacterial factor

doesn't count too!

Best to you and all, Starla

[Guest guest]

Does anyone know if tetracycline has this same immunosupressant effect of

loading the T-cells with calcium as minocycline? Liz G