Joan Has a Question

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Mult Scler. 2002 Feb;8(1):30-5. Related Articles, Links

A double-blind pilot study of the effect of Prokarin on fatigue in

multiple sclerosis.

Gillson G, TL, RB, JV.

Life Diagnostics, Calgary, Alberta, Canada.

In this 12-week study with 29 subjects, the effect of Prokarin

(n=22), a proprietary blend of histamine and caffeine, was compared

to placebo group (n=7) for the following outcomes: 1) fatigue as

measured by the Modified Fatigue Impact Scale (MFIS); 2) lower limb

function as measured by timed walk test; 3) upper limb function as

measured by the pegboard test; 4) cognitive function as measured by

the Paced Auditory Serial Additions Test (PASAT); 5) serum caffeine

level; 6) change in brain chemistry as measured by quantitative

magnetic resonance spectroscopy assay of N-acetyl aspartate (NAA);

and 7) safety as measured by routine blood chemistry, TSH and

urinalysis. Data were acquired at baseline, 4, 8 and 12 weeks. The

Prokarin group MFIS mean was significantly different rom the mean of

the placebo group at 12 weeks (df=24, t=2.08, P=<0.02), with

respective means of 37.40, SD=15.18, for the Prokarin group and

53.2, SD=11.39 for the controls. For the secondary endpoints (PASAT,

25 foot timed walk, peg test, and magnetic resonance spectroscopy

[MRS]), there were no significant differences between the Prokarin-

treated group and the placebo group. However, there were significant

improvements within the Prokarin group for each of these measures

for the pre- versus posttreatment comparison at 12 weeks. Serum

caffeine data indicated that caffeine exerted no independent effect

on performance. No laboratory abnormalities were seen, and the

treatment was well tolerated. CONCLUSION: There was a modest-size

statistical effect of Prokarin on fatigue in multiple sderosis (MS)

compared with the placebo group. A larger trial is warranted, based

on this pilot study.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 11936486 [PubMed - indexed for MEDLINE]

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Hi Pls'er - Can someone please tell me if they have heard of the Medication

called " Prokarin " ? - The have shown this on a program on t.v. and said it was

being used on MS patients and also PLS patients. It is not FDA approved as of

yet - I just was wondering if anyone else tried it or know more information on

this. I have checked out Prokarin.www.edmsllc.com - I am always looking for

things to help - I was just wondering if anyone knew of this?...Thank You Joan