Guest guest Posted February 28, 2000 Report Share Posted February 28, 2000 1 : Immunopharmacology 1996 Mar;31(2-3):163-9 Related Articles, Books Inflammatory and immunological parameters of disease activity in rheumatoid arthritis patients treated with minocycline. Kloppenburg M, Dijkmans BA, Verweij CL, Breedveld FC Department of Rheumatology, Leiden University Hospital, The Netherlands. The objective of this study was to analyze the anti-inflammatory effect of minocycline in rheumatoid arthritis. Serum samples of 65 RA patients who completed a 26-week randomized double-blind trial of minocycline (100 mg twice a day) versus placebo were studied. In this trial some clinical parameters and in particular the acute phase response decreased significantly in the minocycline-treated group. Serum levels of albumin and interleukin-6 (IL-6) were compared with CRP levels in order to study the acute phase response. Furthermore, rheumatoid factor (RF) and total immunoglobulin isotypes as well as serum levels of soluble interleukin-2 receptor (sIL2-2R) were determined in order to study immunological parameters of the disease. Immunoglobulins and cytokines were measured by ELISA. Serum levels of albumin remained stable, whereas serum CRP levels decreased both in the minocycline- and in the placebo-treated group. Serum levels of IL-6 decreased in the minocycline-treated group only and this decrease was positively correlated with the decrease in CRP levels. Minocycline significantly decreased serum IgM-RF, IgA-RF, total IgM and total IgA levels. In addition the ratio of IgM-RF/total IgM decreased in the minocycline-treated group. No such changes were observed in the placebo-treated group. The anti-inflammatory effect of minocycline in RA patients may be due to the reduction in the synthesis of IL-6 and rheumatoid factor. Publication Types: a.. Clinical trial b.. Randomized controlled trial PMID: 8861742, UI: 97014909 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- [This message contained attachments] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 28, 2000 Report Share Posted February 28, 2000 Connie- Thank you so much Janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 29, 2000 Report Share Posted February 29, 2000 In a message dated 02/29/2000 6:40:15 AM Eastern Standard Time, CATH2000@... writes: << Has anyone ever e-mailed Dr. Trentham ab >> Hi- You might want to e-mail Dr. Jane Buckner as she is dpoing current research on RP...I think the question of ethnic backgriound was in her questionairre...also know that one of her focuses is on a genetic link re: autoimmune diseases... Janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 29, 2000 Report Share Posted February 29, 2000 here. Very interesting. Most my bloodwork is always normal except for elevated ANA (speckled) and have had elevated IgM and C3 complement. Docs always say it doesn't mean anything but peaked my attention to see article and increased IgM levels responding to Minocycline. I do know that Minocycline has helped me tremendously and that I wouldn't be able to function on a normal level without it. Thanks for all the info. Would recommend people asks docs to at least consider. I didn't realize just how much it helps until I didn't take it, then it became extremely clear that it did help. I do appreciate all the info on this subject. Has anyone ever e-mailed Dr. Trentham about so many of us having Cherokee Indian in our genetic background? Does anyone think that would be wise to do so? Hope all is well with everyone. I will get completed address list out, just having really tough week this week. Will e-mail later about why when I have more time. May everyone's day be touched with a smile and hug!! > > 1 : Immunopharmacology 1996 Mar;31(2-3):163-9 Related Articles, Books > > Inflammatory and immunological parameters of disease activity in > rheumatoid arthritis patients treated with minocycline. > > Kloppenburg M, Dijkmans BA, Verweij CL, Breedveld FC > > Department of Rheumatology, Leiden University Hospital, The > Netherlands. > > The objective of this study was to analyze the anti-inflammatory > effect of minocycline in rheumatoid arthritis. Serum samples of 65 RA > patients who completed a 26-week randomized double-blind trial of > minocycline (100 mg twice a day) versus placebo were studied. In this > trial some clinical parameters and in particular the acute phase > response decreased significantly in the minocycline-treated group. > Serum levels of albumin and interleukin-6 (IL-6) were compared with > CRP levels in order to study the acute phase response. Furthermore, > rheumatoid factor (RF) and total immunoglobulin isotypes as well as > serum levels of soluble interleukin-2 receptor (sIL2-2R) were > determined in order to study immunological parameters of the disease. > Immunoglobulins and cytokines were measured by ELISA. Serum levels of > albumin remained stable, whereas serum CRP levels decreased both in > the minocycline- and in the placebo-treated group. Serum levels of > IL-6 decreased in the minocycline-treated group only and this decrease > was positively correlated with the decrease in CRP levels. Minocycline > significantly decreased serum IgM-RF, IgA-RF, total IgM and total IgA > levels. In addition the ratio of IgM-RF/total IgM decreased in the > minocycline-treated group. No such changes were observed in the > placebo-treated group. The anti-inflammatory effect of minocycline in > RA patients may be due to the reduction in the synthesis of IL-6 and > rheumatoid factor. > > Publication Types: > > * Clinical trial > * Randomized controlled trial > > PMID: 8861742, UI: 97014909 > ----------------------------------------------------------------------- > [Click Here] > ----------------------------------------------------------------------- > ----------------------------------------------------------------------- > > Enter Ht: ft. in. [ o n h e a l t h ] Enter Wt: lbs. > > ----------------------------------------------------------------------- > hi and welcome. maybe we can come up with answers that our doctors > can't Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2000 Report Share Posted March 1, 2000 Hi , I'm glad the articles were helpful....I know I have more somewhere around here :-) The Minocycline has really helped me, too. Dr. Franco just told me that I have fibromyalgia, too, based on his pushing on those pressure points. He was pleased that I am doing very well and told me to keep taking the Minocin and the Zithromax until I see him again next year. Please add me to your address list, when you have the time :-) I've added some information that might be helpful. Let me know if you think that it is appropriate for this list. many hugs to you, Connie Connie Hache 1669 April Loop Richland, WA 99352 (509)943-6137 age 46 diagnosis: dermatomyositis, possibly RP treatment: low dose, long term Minocin and Zithromaz you can find my story (hopefully in the near future) at www.rheumatic.org Please contact me if you have any questions concerning treating connective tissue diseases such as RA, Lupus, Scleraderma, Reactive Arthritis, Dermatomyositis, Polymyositis, and Fibromyalgia with antibiotics. Many people are finding out that this treatment gets to the root cause of these diseases. New research is finding many of these people have a mycoplasma infection. To: Rpolychondritisonelist Sent: Tuesday, February 29, 2000 3:42 AM Subject: Re: 2nd referenced article here. Very interesting. Most my bloodwork is always normal except for elevated ANA (speckled) and have had elevated IgM and C3 complement. Docs always say it doesn't mean anything but peaked my attention to see article and increased IgM levels responding to Minocycline. I do know that Minocycline has helped me tremendously and that I wouldn't be able to function on a normal level without it. Thanks for all the info. Would recommend people asks docs to at least consider. I didn't realize just how much it helps until I didn't take it, then it became extremely clear that it did help. I do appreciate all the info on this subject. Has anyone ever e-mailed Dr. Trentham about so many of us having Cherokee Indian in our genetic background? Does anyone think that would be wise to do so? Hope all is well with everyone. I will get completed address list out, just having really tough week this week. Will e-mail later about why when I have more time. May everyone's day be touched with a smile and hug!! Quote Link to comment Share on other sites More sharing options...
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