Re: WebMD - Guillain-Barré Syndrome -- Topic Overview

June 19, 2003

Thank you SOOOO much for the spelling!

I had forgotten that my friend's outbreak coincided with her flu

shot! I don't ever get vaccines!

*****I do hate the term anecdotal, he said she said!

I couldn't read what you sent, but with the correct spelling I was

able to get this:

---Guillain-Barré syndrome is thought to be an autoimmune disease.

Vaccines stimulate the immune system.

Theoretically stimulating the immune system might exacerbate or lead

to a reappearance of an autoimmune disease. There are anecdotal

reports of GBS occurring soon after immunizations.1-5 There was an

increase in incidence of GBS after the " swine flu " virus vaccine

program in the United States in 1976.6 More recent information

suggests that the occurrence of GBS after currently used influenza

and other vaccines is extremely rare.7 Case control studies have

shown no evidence of a significant increase in risk of having

received an immunization preceding GBS compared with contemporary

controls.8-10 Retrospective examination of the incidence of GBS for

the seasons of the 1992- 1993 and 1993-1994 influenza vaccination

programs in the United States suggested that influenza vaccination

only caused one to two extra cases of GBS per million vaccinees.11

Despite this evidence, the belief that GBS is an autoimmune condition

and the knowledge that immunizations are designed to activate the

immune system give rise to continued unease about immunization

following the disease. 12;13 This unease is enhanced by a report of

two cases of GBS recurring following swine influenza vaccine.14 In

addition recurrent attacks of chronic inflammatory demyelinating

polyradiculoneuropathy have followed tetanus toxoid immunization.12-

15 However many patients have received immunizations after the acute

phase of their disease, sometimes repeatedly,16 without suffering a

relapse. The number of such patients has, however, not been monitored

and the actual risk is not known. In the absence of adequate evidence

and the difficulty of conducting an adequately powered randomised

trial, it would be appropriate to audit a recovered GBS patient

population to discover what proportion has received immunisations and

what was the outcome.

Although the experiment has never been done in GBS, patients with

multiple sclerosis have been randomized to receive or not receive

influenza vaccine and no evidence emerged to suggest that

immunisation stimulated relapse.17;18 In a recent thorough review

Flachenecker et al.19 found no evidence that immunisation adversely

effects the course of multiple sclerosis. In the case of influenza

vaccine and hepatitis B vaccines this conclusion was based on large

epidemiological studies.

Conclusion

1. In patients who have previously had GBS recurrence of GBS after

immunisation is rare.

2. The need for a particular immunisation requires careful evaluation

on an individual basis.

3. Immunisations should not be performed during the acute phase of

GBS and should probably be avoided until at least one year after the

onset of the disease.

4. If GBS occurred within six weeks after an immunisation, the

patient should not receive that immunisation again.

In LUPIES , " Carol " <neal3884@b...> wrote:

> Hope this is it. I know that my mom had this. It is scary but you

need medical attention quickly. and a quick dxs. mom had to learn to

eat, write, walk, do everything over. but she bounced back. Love and

praying Carol

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> <span class=noanchor-headline>

> <span class=article-title>

> <font color= " #000000 " >Guillain-Barr & #233; Syndrome</font>

> <br><br>

> <font color= " #666666 " >Topic Overview</font>

> </span>

>

> <br><br>

>

> <p>

> <img src= " /NR/rdonlyres/CB293A61-FCF5-4BB4-AF1E-

B8ED9859021C.jpg " align= " left " ><script language=javascript>if

(Common_is_MSN()) document.write('<br

clear=left>');</script></img>Guillain-Barr & #233; syndrome (GBS)

> is an uncommon nervous system disorder that

results from nerve damage caused

> by the body's own defenses (<a

href= " /NR/internal.asp?GUID={23D6873E-82DD-4B98-8F1A-B800427703A7}

#sti150867 " >immune system</a>), usually in response to

> a viral or bacterial infection or other illness.

GBS causes muscle

> weakness, loss of reflexes, and numbness or

tingling in the arms, legs, face, and other parts

> of the body. It may progress to complete

> <a href= " /NR/internal.asp?GUID={02D67EE9-D53C-48A7-

A3C1-D75DDD50EEF0}#stp1255 " >paralysis</a>. Difficulties in breathing

and swallowing

> can also occur. Although GBS can be life-

threatening, most people recover with

> few lasting problems.</p>

> <p>Symptoms usually start with numbness or tingling

in the fingers and

> toes followed by weakness in the leg and arm

muscles that develops over a

> period of days to weeks. Hospital treatment is

often needed during this

> time. The weakness then stabilizes and gradually

improves within the following few

> months. The recovery period may last 12 months or

longer. Serious cases of GBS may

> require hospitalization in an intensive care

unit.</p>

> <p>Treatment for GBS may include <a

href= " /NR/internal.asp?GUID={9C8B15FB-CEE5-4621-B9B9-1F93A218A586}

#tf1512 " >immunotherapy</a>, which

> is designed to alter or combat the abnormal immune

response by removing the

> antibodies that are attacking the nerves.

Immunotherapy may speed

> recovery in many people when it is used early in

the course of the disease. Treatment

> also involves preventing and managing complications

(such as breathing problems

> or infections) and providing supportive care until

symptoms begin to improve.

> Physical therapy and exercise are used throughout

recovery to help restore

> muscle strength and movement.</p>

> <p>Guillain-Barr & #233; syndrome is the most common

medical cause of acute

> paralysis. It is also called acute (or subacute)

inflammatory demyelinating

> polyradiculoneuropathy.</p>

>

> <p><b>Cause</b></p>

> <p>Although the specific cause of Guillain-

Barr & #233; syndrome (GBS) is

> not known, it is believed that the disorder

is an

> <a href= " /NR/internal.asp?GUID={90018CB6-

4B90-4884-A590-AA8CCDFA9D79}#sta123369 " >autoimmune disease</a>.

Nerves are damaged by the body's own defenses (immune system),

> usually in response to a viral or bacterial

infection or other illness. As the

> immune system produces <a

href= " /NR/internal.asp?GUID={7934D6C6-FD55-4CE6-9326-CB62138C3B7B}

#sta123301 " >antibodies</a> to

> fight the infection or illness, it may also

produce antibodies that attack the

> covering of the nerves (<a

onClick= " Common_open_popup

('Healthwise_pop',this.href,'410','496','100','100'); return(false); "

href= " /NR/internal.asp?GUID={5C223E3D-28D3-48A4-AF97-18E0A531A940}

#tp12596 " >myelin sheath</a><img border=0 src= " /NR/rdonlyres/8B58CE72-

E689-43C0-A431-8B2855B2962A.gif " >) and sometimes the nerve

> fibers (axons) themselves, which carry

electrical impulses. The resulting nerve

> damage leads to altered sensations, muscle

weakness, and paralysis.</p>

> <p>Although it is not known exactly what triggers

the body to

> respond in this way, GBS most often develops

after a respiratory or intestinal

> infection. A variety of infections may be

associated with GBS. Those

> that have been most commonly linked to the

disease are <i>Campylobacter jejuni</i> (a bacterial infection that

affects the

> intestinal tract), mycoplasma (a type of

bacteria that can cause pneumonia),

> <a href= " /NR/internal.asp?GUID={C381A1E8-

E451-446C-A607-984ACB63476E}#stc123783 " >cytomegalovirus (CMV)</a>,

> <a href= " /NR/internal.asp?GUID={DF505D86-

5339-4195-BE01-2A6C8FA21E06}#ste122094 " >Epstein-Barr virus (EBV)</a>,

and the varicella zoster

> virus.</p><p>GBS most often occurs in the

spring and autumn.</p>

> <p>It is believed that many cases of GBS in 1977

were

> caused by a flu vaccine used during an

outbreak of an uncommon

> form of influenza called swine flu, but this

was never proven. A different flu

> vaccine is used now, and no increase in

cases of GBS has been observed with these

> vaccines in the past 20 years.</p>

> <p>A cause-and-effect relationship has not been

established between

> any vaccine currently in use and GBS. None

of the vaccines currently used have

> been shown to increase a person's risk of

getting GBS.</p>

>

> <p><b>Who does the disease affect?</b></p>

> <ul><li>1 to 2 people in every 100,000 develop

> Guillain-Barr & #233; syndrome (GBS)

each year.<sup><a href= " /NR/internal.asp?GUID={EFB215A4-4A1B-4589-

8692-285F1FC11F15} " >1</a></sup></li><li>GBS affects men and women

> equally.</li><li>GBS occurs in all

age groups.</li>

> </ul>

>

> </span>

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src= "

June 21, 2003

June 22, 2003

I am adamant in my opposition to " routine " vaccines. Doctors should

tell their patients that there is " anecdotal " evidence of adverse

events and even death with vaccines! I fought tooth and nail over my

daughters vaccines. She never felt a needle until after she was 6

mos old. I delayed what I could and she will never get the

hepatitis vaccine as long as I have any say in the matter.

Do you or anyone know what the restrictions are on international

travel if you DONT get all the shots???

> > Hope this is it. I know that my mom had this. It is scary but

you

> need medical attention quickly. and a quick dxs. mom had to learn

to

> eat, write, walk, do everything over. but she bounced back. Love

and

> praying Carol

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> > <td valign= " top " ><img src= " /NR/rdonlyres/8FE26C01-83AE-444F-

958B-

> 9C5F74A4D3A2.gif " align=top> & nbsp;</td>

> > <td><span class=credits><b><a href= " /NR/internal.asp?GUID=

{63D5CDD0-

> 33CA-4C01-AD02-D669A76D4F01} " >Treatment

Overview</b></span></a></td>

> > </tr>

> >

> > <tr>

> > <td></td>

> > <td valign= " top " ><img src= " /NR/rdonlyres/8FE26C01-83AE-444F-

958B-

> 9C5F74A4D3A2.gif " align=top> & nbsp;</td>

> > <td><span class=credits><b><a href= " /NR/internal.asp?GUID=

{8AFA5433-

> 702F-40D9-8FB1-8690994D0CC1} " >Home Treatment</b></span></a></td>

> > </tr>

> >

> > <tr>

> > <td></td>

> > <td valign= " top " ><img src= " /NR/rdonlyres/8FE26C01-83AE-444F-

958B-

> 9C5F74A4D3A2.gif " align=top> & nbsp;</td>

> > <td><span class=credits><b><a href= " /NR/internal.asp?GUID=

{EFD806F8-

> 7F30-4F16-A10B-6858BDD6FC9B} " >Other Places to Get

> Help</b></span></a></td>

> > </tr>

> >

> > <tr>

> > <td></td>

> > <td valign= " top " ><img src= " /NR/rdonlyres/8FE26C01-83AE-444F-

958B-

> 9C5F74A4D3A2.gif " align=top> & nbsp;</td>

> > <td><span class=credits><b><a href= " /NR/internal.asp?GUID=

{EFB215A4-

> 4A1B-4589-8692-285F1FC11F15} " >References</b></span></a></td>

> > </tr>

> >

> > <tr>

> > <td></td>

> > <td valign= " top " ><img src= " /NR/rdonlyres/8FE26C01-83AE-444F-

958B-

> 9C5F74A4D3A2.gif " align=top> & nbsp;</td>

> > <td><span class=credits><b><a href= " /NR/internal.asp?GUID=

{8A221D9F-

> 7E60-4950-B185-9C6D0BC81E98} " >Credits</b></span></a></td>

> > </tr>

> >

> > <tr height= 8><td colspan=3></td></tr>

> > <tr>

> > <td></td>

> > <td colspan= 2 bgcolor= " #306363 " height=2></td>

> > </tr>

> > <tr height= 8><td colspan=3></td></tr>

> > </table>

> >

> > <span class=noanchor-headline>

> > <span class=article-title>

> > <font color= " #000000 " >Guillain-Barr & #233; Syndrome</font>

> > <br><br>

> > <font color= " #666666 " >Topic Overview</font>

> > </span>

> >

> > <br><br>

> >

> > <p>

> > <img src= " /NR/rdonlyres/CB293A61-FCF5-4BB4-AF1E-

> B8ED9859021C.jpg " align= " left " ><script language=javascript>if

> (Common_is_MSN()) document.write('<br

> clear=left>');</script></img>Guillain-Barr & #233; syndrome (GBS)

> > is an uncommon nervous system disorder that

> results from nerve damage caused

> > by the body's own defenses (<a

> href= " /NR/internal.asp?GUID={23D6873E-82DD-4B98-8F1A-B800427703A7}

> #sti150867 " >immune system</a>), usually in response to

> > a viral or bacterial infection or other illness.

> GBS causes muscle

> > weakness, loss of reflexes, and numbness or

> tingling in the arms, legs, face, and other parts

> > of the body. It may progress to complete

> > <a href= " /NR/internal.asp?GUID={02D67EE9-D53C-

48A7-

> A3C1-D75DDD50EEF0}#stp1255 " >paralysis</a>. Difficulties in

breathing

> and swallowing

> > can also occur. Although GBS can be life-

> threatening, most people recover with

> > few lasting problems.</p>

> > <p>Symptoms usually start with numbness or tingling

> in the fingers and

> > toes followed by weakness in the leg and arm

> muscles that develops over a

> > period of days to weeks. Hospital treatment is

> often needed during this

> > time. The weakness then stabilizes and gradually

> improves within the following few

> > months. The recovery period may last 12 months or

> longer. Serious cases of GBS may

> > require hospitalization in an intensive care

> unit.</p>

> > <p>Treatment for GBS may include <a

> href= " /NR/internal.asp?GUID={9C8B15FB-CEE5-4621-B9B9-1F93A218A586}

> #tf1512 " >immunotherapy</a>, which

> > is designed to alter or combat the abnormal

immune

> response by removing the

> > antibodies that are attacking the nerves.

> Immunotherapy may speed

> > recovery in many people when it is used early in

> the course of the disease. Treatment

> > also involves preventing and managing

complications

> (such as breathing problems

> > or infections) and providing supportive care

until

> symptoms begin to improve.

> > Physical therapy and exercise are used throughout

> recovery to help restore

> > muscle strength and movement.</p>

> > <p>Guillain-Barr & #233; syndrome is the most common

> medical cause of acute

> > paralysis. It is also called acute (or subacute)

> inflammatory demyelinating

> > polyradiculoneuropathy.</p>

> >

> > <p><b>Cause</b></p>

> > <p>Although the specific cause of Guillain-

> Barr & #233; syndrome (GBS) is

> > not known, it is believed that the disorder

> is an

> > <a href= " /NR/internal.asp?GUID={90018CB6-

> 4B90-4884-A590-AA8CCDFA9D79}#sta123369 " >autoimmune disease</a>.

> Nerves are damaged by the body's own defenses (immune system),

> > usually in response to a viral or bacterial

> infection or other illness. As the

> > immune system produces <a

> href= " /NR/internal.asp?GUID={7934D6C6-FD55-4CE6-9326-CB62138C3B7B}

> #sta123301 " >antibodies</a> to

> > fight the infection or illness, it may also

> produce antibodies that attack the

> > covering of the nerves (<a

> onClick= " Common_open_popup

> ('Healthwise_pop',this.href,'410','496','100','100'); return

(false); "

> href= " /NR/internal.asp?GUID={5C223E3D-28D3-48A4-AF97-18E0A531A940}

> #tp12596 " >myelin sheath</a><img border=0

src= " /NR/rdonlyres/8B58CE72-

> E689-43C0-A431-8B2855B2962A.gif " >) and sometimes the nerve

> > fibers (axons) themselves, which carry

> electrical impulses. The resulting nerve

> > damage leads to altered sensations, muscle

> weakness, and paralysis.</p>

> > <p>Although it is not known exactly what triggers

> the body to

> > respond in this way, GBS most often develops

> after a respiratory or intestinal

> > infection. A variety of infections may be

> associated with GBS. Those

> > that have been most commonly linked to the

> disease are <i>Campylobacter jejuni</i> (a bacterial infection

that

> affects the

> > intestinal tract), mycoplasma (a type of

> bacteria that can cause pneumonia),

> > <a href= " /NR/internal.asp?GUID={C381A1E8-

> E451-446C-A607-984ACB63476E}#stc123783 " >cytomegalovirus (CMV)</a>,

> > <a href= " /NR/internal.asp?GUID={DF505D86-

> 5339-4195-BE01-2A6C8FA21E06}#ste122094 " >Epstein-Barr virus (EBV)

</a>,

> and the varicella zoster

> > virus.</p><p>GBS most often occurs in the

> spring and autumn.</p>

> > <p>It is believed that many cases of GBS in 1977

> were

> > caused by a flu vaccine used during an

> outbreak of an uncommon

> > form of influenza called swine flu, but this

> was never proven. A different flu

> > vaccine is used now, and no increase in

> cases of GBS has been observed with these

> > vaccines in the past 20 years.</p>

> > <p>A cause-and-effect relationship has not been

> established between

> > any vaccine currently in use and GBS. None

> of the vaccines currently used have

> > been shown to increase a person's risk of

> getting GBS.</p>

> >

> > <p><b>Who does the disease affect?</b></p>

> > <ul><li>1 to 2 people in every 100,000 develop

> > Guillain-Barr & #233; syndrome (GBS)

> each year.<sup><a href= " /NR/internal.asp?GUID={EFB215A4-4A1B-4589-

> 8692-285F1FC11F15} " >1</a></sup></li><li>GBS affects men and women

> > equally.</li><li>GBS occurs in all

> age groups.</li>

> > </ul>

> >

> > </span>

> >

> > <br><br clear= " right " >

> >

> > <table width= " 100% " border= " 0 " >

> > <tr>

> > <td width= " 33% " ><span class= credits></span></td>

> > <td width= " 33% " >^ <a class= credits href= " #top " >back to

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href= " /NR/internal.asp?

> GUID={40F30B85-DCFF-45F3-ADBC-E308D2ABCE7D} " >next section

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