Ban on Tobacco Advertising?

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Rheumatology MedPulse®

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MedPulse is a weekly index of key news and features on Medscape's specialty sites compiled by Medscape's Editors.

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ALSO IN THIS ISSUE:NEWSMEMBER NEWSUSER SUPPORT

NEW FEATURES THIS WEEK

INSTANT POLL

Ban on Tobacco Advertising?

In a Medscape Instant Poll that launched Sept. 15, 86% of respondents said they approve of a ban on tobacco advertising as part of a global treaty recently adopted by the World Health Assembly. But 13% said they disapprove of the ban. As of Sept. 18, a total of 1,269 respondents had taken part in this poll. To view the full results of the poll, which ended on Sept. 22, click on the title above

MORE THIS WEEK

Naturocetic (Glucosamine and Chondroitin Sulfate) Compounds as Structure-Modifying Drugs in the Treatment of Osteoarthritis

Glucosamine sulfate has demonstrated its ability to reduce the progression of osteoarthritis in the lower limbs. The preliminary results obtained in the hands suggest that chondroitin sulfate could also be of interest in this indication. An important issue is that all the conclusive studies with such chemical entities resulted from the use of prescription medicines, not over-the-counter pills or food supplements.Curr Opin Rheumatol 15(5) 2003

Prevalence, Clinical Relevance and Characterization of Circulating Cytotoxic CD4+CD28- T Cells in Ankylosing Spondylitis

These T cells share phenotypic and functional properties of natural killer cells, strongly expressing CD57 but lacking the lymphocyte marker CD7. MHC class I recognizing and activating natural killer cell receptors on the surface of CD4+CD28- T cells may be involved in a HLA-B27 mediated co-stimulation of these proinflammatory and cytotoxic cells.

Arthritis Res Ther 5(5) 2003

Pharmacokinetic Evaluation of Rofecoxib: Comparison of Tablet and Suspension Formulations

The rofecoxib suspension is bioequivalent to the rofecoxib tablet at single oral doses of 12.5mg and 25mg in healthy volunteers. The convenience and ease of administration of rofecoxib suspension may translate into increased compliance with therapy compared with a conventional solid tablet formulation, particularly for elderly patients.Clin Drug Invest 23(8) 2003

The Triterpenoid CDDO Inhibits Expression of Matrix Metalloproteinase-1, Matrix Metalloproteinase-13 and Bcl-3 in Primary Human Chondrocytes

Data demonstrate that CDDO inhibits IL-1-induced MMP-1 and MMP-13 expression in human chondrocytes. CDDO also inhibits the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.Arthritis Res Ther 5(5) 2003

MEDLINE Abstracts: Nonpharmacologic Approaches to Arthritis Pain

TENS; ibuprofen vs ultrasound in knee osteoarthritis; knee taping, laser therapy, exercise and physiotherapy interventionsMedscape Neurology & Neurosurgery 5(2) 2003

An Association Between the Acute Phase Reponse and Patterns of Antigen-Induced T Cell Proliferation in Juvenile Idiopathic Arthritis

The aim of this research was to determine whether all memory T cells have the same propensity to migrate to the joint in patients with juvenile idiopathic arthritis. This is the first report of an association between the acute phase response and the T cell population recruited to an inflammatory site.Arthritis Res Ther 5(5) 2003

MANAGEMENT OF ARTHRITIS PAIN

What is the latest research on nonpharmacologic approaches to

arthritis pain? Find out in "MEDLINE Abstracts: Nonpharmacologic

Approaches to Arthritis Pain," a collection of recent abstracts

compiled by the editors at Medscape Neurology Neurosurgery. NEW

in the "Focus On" section of the Pain Management Resource Center.

NEWS

NEWS CME

Moderate-Intensity Warfarin Appropriate in Antiphospholipid Antibody Syndrome

In a randomized, double-blind trial, INR 2.0 to 3.0 was not associated with higher rate of recurrent thrombosis than that seen with INR of 3.1 to 4.0 in patients with previous thrombosis.Medscape Medical News 2003

MORE NEWS THIS WEEK

Chronic Inflammation Linked to Chromosomal Abnormalities in Synovial Cells

Long recognized for their contribution to malignant transformation, chromosomal aberrations may also have significance in rheumatoid arthritis and other inflammatory conditions.Reuters Health Information 2003

Avocado/Soybean Product Reduces Production of Osteoarthritis Mediators

A novel French product containing elements of avocado and soybean oils reduces the production of inflammatory mediators and increases aggrecan synthesis by human osteoarthritis chondrocytes, according to a report in the August issue of The Journal of Rheumatology.Reuters Health Information 2003

Lyme Borreliosis a Risk in Southeastern States

Based on the prevalence of host reservoirs, tick vectors and genospecies of Borrelia, there is considerable risk for contracting Lyme disease in coastal regions in southeast United States, new study findings indicate.Reuters Health Information 2003

Novartis Pain Drug Prexige Wins British OK

Novartis AG's Prexige drug, a potential blockbuster pain reliever, won its first European approval in Britain, the Swiss healthcare group said on Tuesday, but is still slated for a global launch in 2004.Reuters Health Information 2003

NSAIDs Tied to Non-Hodgkin Lymphoma Risk in Women

Use of nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, appears to be associated with a heightened risk of non-Hodgkin lymphoma (NHL), according to a study of more than 27,000 postmenopausal women.Reuters Health Information 2003

St. 's Wort Increases Metabolism Via CYP 3A4

This effect on the cytochrome P450 (CYP) enzyme system may significantly affect the bioavailability of half of currently marketed drugs. Medscape Medical News 2003

U.S. Medical Journal Questions Herbal Remedies

The editor of a leading U.S. medical journal called on Tuesday for tighter regulation of herbal remedies because of "potentially misleading" health claims made by distributors of the products.Reuters Health Information 2003

Privacy Complaints Reflect Misunderstandings of Rule -- HHS

Most revolve around interactions between healthcare providers and patients.Medscape Medical News 2003

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