Spadt Article/VVS/Crohn's/Colitis

[Guest guest]

" Witkin et al suggest that many women with VVS are

homozygous for allele 2 of the IL-1RA gene (IL1RN*2),

a phenotype that is associated with ulcerative

colitis, Crohn's disease, and lupus erythematosus.

Persons with this phenotype have more prolonged and

more severe proinflammatory immune responses than

those with other IL-1RA genotypes.6 "

Here we are back to those inflammatory bowel diseases

again-- " Crohn's, ulcerative colitis "

The whole article is at the following URL although

this was the most interesting part for me.

http://www.femalepatient.com/html/arc/sig/21st/articles/article_3.asp

Arline

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