Abnormal Fasting Plasma Glucose Linked wit Ischemic Stroke

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Date: Tuesday, October 19 @ 14:39:42 EDT

Topic: DIC Newsletter Issue 230

Ischemic stroke risk increases by 2.82 times when the fasting blood

glucose is greater than 140 mg/dL

There is a J-shaped association between fasting plasma glucose and

incident ischemic cerebrovascular events in subjects with pre-existing

atherothrombotic disease, researchers report.

" Rates increase for fasting plasma glucose levels > 100 mg/dL and also

for those with low fasting glucose levels, " according to their report in

the October issue of Stroke.

Dr. Tanne, of Chaim Medical Center, in Tel-Hashomer, Israel, and

examined the association between various fasting plasma glucose levels

and the risk of incident ischemic stroke in 13,999 patients with

documented coronary heart disease.

Medical histories were obtained, and plasma glucose and lipids were

assessed at baseline. A total of 1037 patients were identified with

ischemic cerebrovascular disease during 6 to 8 years of follow-up.

Ischemic stroke or transient ischemic attack was confirmed in 576.

A positive association was observed between increasing fasting glucose

levels and increasing age, male gender, body mass index, hypertension,

total cholesterol, and triglycerides. Increasing fasting glucose was

inversely associated with high-density lipoprotein cholesterol and

percent high-density lipoprotein of total cholesterol.

After adjusting for potential confounders, the odds ratio of ischemic

cerebrovascular disease were 1.47 for fasting glucose less than 80 mg/dL

and 2.82 for greater than 140 mg/dL, compared to those with levels of 90

to 99 mg/dL.

" Relative odds in patients without a diagnosis of diabetes mellitus and

for the end-point ischemic stroke/transient ischemic attack exhibited

similar trends, " the researchers write.

Stroke 2004;35:2351-2355

cappie

Greater Boston Area

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