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Alzheimer's and thyroid

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In a message dated 6/22/2004 11:31:25 AM Eastern Standard Time,

d_timmsjosey@... writes:

> This is confusing because Dr. Derry states that there may be a link

> between low thyroid function and Alzheimer's. He has even stated that

> he can and has slowed down or stopped the progression with thyroid

> hormone supplementation in individuals that come to him early in the game.

>

Did you think the mainstream medical folks would admit that Alzheimer's might

possibly be just someone needing some Armour? :)

Cindi

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This is confusing because Dr. Derry states that there may be a link

between low thyroid function and Alzheimer's. He has even stated that

he can and has slowed down or stopped the progression with thyroid

hormone supplementation in individuals that come to him early in the game.

>

> OK, here is an article that confuses me. This says low levels. Does

that mean suppressed which I keep my levels at or high levels?

>

> Home | Newsletters| Bookstore | News | Community | Links |

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> HOME > ARTICLES > ARTICLE

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> Latest Update: June 22, 2004

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>

> Low TSH Levels Are a Risk Factor for Alzheimer's Disease

>

>

>

> by Shomon

>

> June 2004 -- A study published in the June 8th issue of the

journal Neurology indicates that low thyroid-stimulating hormone (TSH)

levels may be linked to a risk of developing Alzheimer's disease.

British researchers measured TSH levels in 178 patients with

Alzheimer's disease, and 291 control subjects with normal TSH levels.

The patients with Alzeimers had lower TSH compared to the control

subjects, resulting in a two-fold increased risk of Alzheimer's

disease in peope with lower TSH levels.

>

> The article states: " Low TSH levels could be a consequence of

Alzheimer-related neuro-degeneration leading to reduced hypothalamic

thyrotropin-releasing hormone (TRH) secretion or decreased pituitary

responsiveness and consequently low TSH levels. Low TSH or TRH levels

could also precede dementia. "

>

> Source: Neurology 2004;62:1967-1971.

>

>

>

>

>

>

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Although this is not the complete article, it sounds very interesting:

Association between autoimmune thyroid disease and familial

Alzheimer's disease.

Department of Medicine, King's College School of Medicine, London, UK.

OBJECTIVE: To determine the prevalence of autoimmune thyroid disease

in Familial Alzheimer's Disease kindreds and to ascertain whether

there is any evidence for genetic linkage between the two conditions.

DESIGN: Retrospective study of Familial Alzheimer's Disease kindreds.

PATIENTS: Seventy affected and unaffected family members from 12

kindreds. MEASUREMENTS: Anti-thyroglobulin and anti-microsomal

autoantibody status was determined using an enzyme-linked

immunosorbent assay. Thyrotrophin levels were determined by an

immunoradiometric assay. RESULTS: Of the family members, 41.4% had

evidence of autoimmune thyroid disease, with significant

co-segregation between the presence of thyroid autoantibodies and the

development of Alzheimer's disease (P less than 0.01). CONCLUSIONS:

This study demonstrates a very high prevalence of autoimmune thyroid

disease in Familial Alzheimer's Disease kindreds and suggests that a

genetic factor contributing towards the development of autoimmune

thyroid disease may be located on chromosome 21 within close proximity

to the Familial Alzheimer's Disease gene

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Although this is not the complete article, it sounds very interesting:

Association between autoimmune thyroid disease and familial

Alzheimer's disease.

Department of Medicine, King's College School of Medicine, London, UK.

OBJECTIVE: To determine the prevalence of autoimmune thyroid disease

in Familial Alzheimer's Disease kindreds and to ascertain whether

there is any evidence for genetic linkage between the two conditions.

DESIGN: Retrospective study of Familial Alzheimer's Disease kindreds.

PATIENTS: Seventy affected and unaffected family members from 12

kindreds. MEASUREMENTS: Anti-thyroglobulin and anti-microsomal

autoantibody status was determined using an enzyme-linked

immunosorbent assay. Thyrotrophin levels were determined by an

immunoradiometric assay. RESULTS: Of the family members, 41.4% had

evidence of autoimmune thyroid disease, with significant

co-segregation between the presence of thyroid autoantibodies and the

development of Alzheimer's disease (P less than 0.01). CONCLUSIONS:

This study demonstrates a very high prevalence of autoimmune thyroid

disease in Familial Alzheimer's Disease kindreds and suggests that a

genetic factor contributing towards the development of autoimmune

thyroid disease may be located on chromosome 21 within close proximity

to the Familial Alzheimer's Disease gene

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