Guest guest Posted March 9, 2000 Report Share Posted March 9, 2000 Sorry I didn't answer this. It got lost in my mailbox. I can't find anything yet, but I am still looking. I DID find this that came from the package insert: VIOXX®(rofecoxib tablets and oral suspension) 9183800 OVERDOSAGE No overdoses of VIOXX were reported during clinical trials. Administration of single doses of VIOXX 1000 mg to 6 healthy volunteers and multiple doses of 250 mg/day for 14 days to 75 healthy volunteers did not result in serious toxicity. In the event of overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required. Rofecoxib is not removed by hemodialysis; it is not known whether rofecoxib is removed by peritoneal dialysis. DOSAGE AND ADMINISTRATION VIOXX is administered orally. The lowest dose of VIOXX should be sought for each patient. Osteoarthritis The recommended starting dose of VIOXX is 12.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 25 mg once daily. The maximum recommended daily dose is 25 mg. Management of Acute Pain and Treatment of Primary Dysmenorrhea The recommended initial dose of VIOXX is 50 mg once daily. Subsequent doses should be 50 mg once daily as needed. Use of VIOXX for more than 5 days in management of pain has not been studied (see CLINICAL STUDIES, Analgesia, including dysmenorrhea). VIOXX tablets may be taken with or without food. Oral Suspension VIOXX Oral Suspension 12.5 mg/5 mL or 25 mg/5 mL may be substituted for VIOXX Tablets 12.5 or 25 mg, respectively, in any of the above indications. Shake before using. ----- Original Message ----- From: Valued Compaq Customer <ruf-caimi@...> < onelist> Sent: Thursday, March 02, 2000 7:26 PM Subject: [ ] vioxx > From: " Valued Compaq Customer " <ruf-caimi@...> > > a, > I remember weeks ago someone wrote something about vioxx and taking too > much. My doctor keeps telling me to take two a day, thats 50mg. > Everything I see says only take 1 a day. Do you or anyone else remember > what the problem was with taking 2 a day. > Thanks > > > ------------------------------------------------------------------------ > DON'T HATE YOUR RATE! > Get a NextCard Visa, in 30 seconds! Get rates as low as > 0.0% Intro or 9.9% Fixed APR and no hidden fees. > Apply NOW! > 1/2120/3/_/478567/_/952044078/ > ------------------------------------------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2000 Report Share Posted March 9, 2000 I sent in several articles, and the dosage say that 50mg is the normal prescribing strength for pain. I was surprised that many articles say that there are no studies on side effects for anyone taking vioxx longer than 5 days. If this is prescribed for long term pain, I am surprised that it got FDA approval without testing longer than 5 days. All of the sites say to make sure you get regular blood tests to check for liver enzymes. a ----- Original Message ----- From: Valued Compaq Customer <ruf-caimi@...> < onelist> Sent: Thursday, March 02, 2000 7:26 PM Subject: [ ] vioxx > From: " Valued Compaq Customer " <ruf-caimi@...> > > a, > I remember weeks ago someone wrote something about vioxx and taking too > much. My doctor keeps telling me to take two a day, thats 50mg. > Everything I see says only take 1 a day. Do you or anyone else remember > what the problem was with taking 2 a day. > Thanks > > > ------------------------------------------------------------------------ > DON'T HATE YOUR RATE! > Get a NextCard Visa, in 30 seconds! Get rates as low as > 0.0% Intro or 9.9% Fixed APR and no hidden fees. > Apply NOW! > 1/2120/3/_/478567/_/952044078/ > ------------------------------------------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 28, 2000 Report Share Posted April 28, 2000 , I know what you mean about getting off the prednisone. Its so easy to increase and impossible to decrease. Sounds like a fun trip to burg and what a great place for archeology digs. I lived very close to town, what a place!! I hope your blood pressure comes down soon. Take care of yourself!! Trish --- Valued Compaq Customer <ruf-caimi@...> wrote: > Hi Trish, > I am having problems with my blood pressure being very high, I take > medicine for it but the last six weeks it has gotten out of control. The > Rheumy thought there is a small chance that it could be from the vioxx, so > I have to stop it for two weeks and see what happens. If the bp remains > high than it is not the vioxx and I start it up again, if it is we try > something else. The pharmacist looked it up and doesn't believe the vioxx > could be the problem, however, I have the insert that comes with the vioxx > and it can be a rare side effect. > I'm not coming off of the pred, but because we stopped the vioxx I may > need to increase the dosage I am on. I am trying not to do this because it > is so hard to get it back down, but if I have to increase it I will. > My trip to burg is with the college I go to, and I can't wait. We > are going to town, Flowerdew Hundred, and 's Hundred. It is > with an archaeology class, we are going behind the scene and see how they > uncover the artifacts. I am going to get a cane because I know I won't be > able to keep up. I love burg, I have taken my daughters to Busch > Gardens a few times, I don't think I could do that anymore, too much > walking. What a great place to work!! Anyway I am looking forward to > going. > How are you doing??? Hope today is a good one for you!!!!!!!! > > > ------------------------------------------------------------------------ > High rates giving you headaches? The 0% APR Introductory Rate from > Capital One. 9.9% Fixed thereafter! > 1/3010/4/_/478567/_/956830542/ > ------------------------------------------------------------------------ > > URL to change your membership options: /group/ > RA-support website: http://www.rasupport.webprovider.com/ > Our chat room: www.delphi.com/RheumatoidArth1/start > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2000 Report Share Posted May 1, 2000 , What are they planning to give you for an anti-inflammatory? Pain raises Blood Pressure too - why must you go a whole week without medication? That just doesn't seem right. Can't you call your doctor and tell him? You could do some real damage to your joints without an anti-inflammatory. Be very careful this week if you cannot get in to see your doctor before next week. Not to scare you, but joints can be destroyed overnight. RA is relentless at times. Good for you with the cane! They really do help take some pressure off the other joints. Take care, . Judy ~~**~~**~~**~~**~~**~~**~~**~~**~~**~ http://www.rasupport.webprovider.com/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2000 Report Share Posted May 1, 2000 ......how much prednisone do you take. That was the only drug that worked for Esther when she was a child......however, the prednisone made her blood pressure high. She has been off it for years (since age 13) and her blood pressure is actually on the low side now. Just a thought.........could be the prednisone that may be making yours so high. ~ Carol ~ ----- Original Message ----- From: Valued Compaq Customer <ruf-caimi@...> < egroups> Sent: Monday, May 01, 2000 3:56 PM Subject: [ ] vioxx > Hi Judy, > I thought it was the RA, it hurts. I had to come off the > anti-inflammatory drug vioxx, because my blood pressure is so high, the > doctor wanted to see if that was what was doing it. I didn't expect > everything to kick in so fast. If it keeps up I can up the pred., not > something I want to do but if I have no choice I will. > I just brought a cane today. Takes a little getting use to needing a > cane. I want to go to burg so I need a little help. > Hope you day is good!!! > > > ------------------------------------------------------------------------ > *--- FREE VOICEMAIL FOR YOUR HOME PHONE! ---* > With eVoice Now you can keep in touch with clients, vendors, co-workers, > friends and family ANYTIME, ANYWHERE. Sign Up Today for your FREE! > 1/3426/4/_/478567/_/957211070/ > ------------------------------------------------------------------------ > > URL to change your membership options: /group/ > RA-support website: http://www.rasupport.webprovider.com/ > Our chat room: www.delphi.com/RheumatoidArth1/start Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2000 Report Share Posted May 1, 2000 , About how long have you had blood pressure problems? Sorry if I forgot! You were on an ACE-inhibitor before Vioxx was added, right? How long have you been on prednisone? Check out this link from the FDA which mentions that care must be taken if using Vioxx with an ACE-inhibitor and that one of the known side effects of Vioxx use is high blood pressure: http://www.fda.gov/CDER/consumerinfo/druginfo/vioxx.htm ----- Original Message ----- From: " Ruf-Caimi " <ruf-caimi@...> < egroups> Sent: Monday, May 01, 2000 3:47 PM Subject: [ ] vioxx > Hi Judy, > They are hoping to get me back on vioxx, if that is causing the > problem then it will be something else. He never did say what??? In > four weeks I am either going into a drug study for a new TNF, that is > one injection a week. Suppose to be a lot like enbrel. Or it is > remicade for me. He would rather the drug study, said it is less > invasive. I'm not sure but I think he is a little skittish because so > many drugs have not worked for me. I am thinking he should have know > that vioxx didn't mix well with an ACE inhibitor. If on next Tuesday > the vioxx is the problem then I have some thinking to do. I pay him a > lot of money and I think he should know what drugs I'm on and how they > interact with other drugs. I make sure at every appointment to update > him on all drugs I am taking since I go to two doctors. So far I have > really liked him and trusted him, so I don't know. > Thank You for your help, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2000 Report Share Posted May 9, 2000 , I am glad they got to the bottom of this!! Great news about your BP. Are they giving you anything in it's place or do you have to wait until your system is more stable? a ----- Original Message ----- From: Valued Compaq Customer <ruf-caimi@...> < egroups> Sent: Tuesday, May 09, 2000 1:31 PM Subject: [ ] vioxx > Hello, > Well it seems my bp problems where from the vioxx. When I went to the > doctors today it was 106/60 and in the last two weeks I lost 9 pounds. No > more vioxx for me, I still have a bp problem but now they are dropping the > medicine a little and just trying to get it regulated. What a relief, I > was shocked when I saw how much weight I lost, not complaining but I know I > don't eat much and these few months I couldn't understand why I wasn't > losing. > > > ------------------------------------------------------------------------ > Get your money connected @ OnMoney.com - the first Web site that lets > you see and manage all of your finances all in one place. > 1/3012/6/_/478567/_/957894051/ > ------------------------------------------------------------------------ > > URL to change your membership options: /group/ > RA-support website: http://www.rasupport.webprovider.com/ > Our chat room: www.delphi.com/RheumatoidArth1/start > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2000 Report Share Posted May 9, 2000 , I've read about that study. It sounds like it will be very similar to Enbrel. Your family doctor has rights to be annoyed that your rheumy made such a mistake with both the Lotensin and the Vioxx. For your rhuemy to not understand why you're not responding makes me wonder what school he went to!!! There are many of us that do not respond, I being one of them. The NSAIDS may reduce my inflammation and the pain meds may take some of the pain away, but the disease is still chewing up my joints. It is also still spreading, very slowly, but still on the move even with Enbrel. Sed rates are as fickle as the weather. From one month to another, mine has changed from the 40's to the 100's. I can't correlate anything being the cause of the rise or fall. I absolutely disagree with your doctor that the sed rate doesn't indicate pain. Inflammation causes pain and the sed rate measures inflammation so how can he make such a statement? What does anyone else here think of that statement? Just because your sed rate is not high, it doesn't mean you aren't in pain. It just means that your inflammation is not alarmingly high. RA damages the joints and erodes the lining of the joints leaving bone on bone. THAT HURTS!!!! I am so glad your BP is down and you can now enjoy the pool! There's no better way to keep those joints moving! a ----- Original Message ----- From: Valued Compaq Customer <ruf-caimi@...> < egroups> Sent: Tuesday, May 09, 2000 3:20 PM Subject: [ ] vioxx > Hi a, > I think tomorrow they are giving me something else. In June I am going to > go into a drug study. He doesn't want to use the ramicade yet. This drug > is very similar to embrel, but you give yourself the injection once a week. > I understand I still have hypertension but he has to get it straightened > out. My family doctor seemed a little annoyed that the Rheumy didn't > realize Lotensin is an ACE Inhibitor. Plus, the recommended dose is 12 1/ 2 > to 25 Mg a day and the Rheumy doesn't feel this is enough and I was on 50 > MG a day. > The other thing that puzzles me is the sed rate is 38 which is good, so > why do I hurt so much. I am thinking of not going to class tonight. My > hips hurt so much. The doctor told me the sed rate has nothing to do with > pain. I ask him if he is 100% sure I have RA, and he said yes. He just > doesn't understand why no drug has helped me. > Today, was good at least the bp is better, I was worried. Maybe, now I > feel better going to just the pool, I have missed it. > > > ------------------------------------------------------------------------ > Get your money connected @ OnMoney.com - the first Web site that lets > you see and manage all of your finances all in one place. > 1/3012/6/_/478567/_/957900104/ > ------------------------------------------------------------------------ > > URL to change your membership options: /group/ > RA-support website: http://www.rasupport.webprovider.com/ > Our chat room: www.delphi.com/RheumatoidArth1/start > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 29, 2000 Report Share Posted December 29, 2000 Hello all, a few weeks ago I asked you all about Vioxx. I have now been taking it only 3 weeks and so much of the inflammation is GONE and therefore my pain level in hip and back is greatly decreased. I am taking 25 mg once a day.I can now get back into my stretching routine. This is interesting too: my burning feet pain I have had my whole life seems to be gone! I just noticed that last night - was amazed. Seems like a good side benefit. I have had no side effects or adverse/ill effects from Vioxx. Matter of fact over the holidays went to several parties, stood up, chatted,felt very happy feeling no pain. Just wanted to share that with you. And thank you to all Vioxx users who shared your experience with me before I started it. ~ Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 29, 2000 Report Share Posted December 29, 2000 In a message dated 12/29/00 12:28:06 PM Eastern Standard Time, liliwigg@... writes: << And thank you to all Vioxx users who shared your experience with me before I started it. >> Helloooooooo Gretchen, Was that you running down the street yesterday? Three cheers for vioxx, glad your on top of your game. E Quote Link to comment Share on other sites More sharing options...
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