Guest guest Posted June 10, 2006 Report Share Posted June 10, 2006 asked: " would anyone know if the generic forms of naltrexone (antaxone, nalorex, etc) are the same as or are as good as the Revia. I make my own LDN and have been using Revia. I have some Nodict tablets, they say 50mg naltrexone, but am not sure if they are the same thing, or the generic forms. " Hi ! Good question. The word " generic " doesn't have much meaning for Naltrexone tablets anymore. At this point, ALL forms of 50 or 100mg tablets of naltrexone are generic. Here's the deal... The original (that is, the non-generic) 50mg Naltrexone Revia tablet was manufactured by DuPont, starting in January 1995. Revia was actually a re-named version of DuPont's previous 50mg Naltrexone tablet, brand-named Trexan, which had been FDA approved in 1984 for opiate abuse. Dupont renamed Trexan when it was FDA approved for alcohol abuse in 1995. In 1997, Dupont's market exclusivity agreement for Revia lapsed, which means that other companies were now free to manufacture and market generic naltrexone. In May 1998, the first generic version of ReVia was produced by Barr Laboratories in Pomona NY. In 2001, Bristol Myers Squibb acquired DuPont Pharmaceuticals. In April 2002, Bristol Myers Squibb sold the ReVia brand-name rights in the U.S. and Canada to Barr Laboratories, who had been making " generic " naltrexone for four years. Right now, Barr manufactures ReVia in 50mg pills in the U.S and Canada. Bristol Myers Squibb continues to market ReVia in countries outside of the U.S. and Canada. You can see how the " original " vs " generic " pedigree begins to lose its meaning in here somewhere.... Other versions of naltrexone are currently manufactured in the U.S. by Eon Labs and Amide Pharmaceutical; Mallinckrodt Pharmaceuticals manufactures 50mg and 100mg naltrexone pills in the U.S. under the trade name Depade. Other 50mg versions of naltrexone are named Nalorex (manufactured by Bristol-Myers Squibb in the UK); Nodict (manufactured by Sun Pharma in India); Naltima (manufactured by INTAS in India), Narpan (by Duopharma in Malaysia), Antaxone (by Pharmazam in Spain), Celupan (by Lacer in Spain), Narcoral (by Siton in Italy), Nemexin (Bristol Myers Squibb in Germany), as well as Revez, Naltrexona, and Naltrexonum. Although all of these brand-name tablets contain naltrexone, each tablet also contains about 84% filler. Each manufacturer uses a different combination of filler ingredients. It's the filler, rather than the naltrexone itself, which accounts for differences in patient reactions to the various brands. For more information about the history of Naltrexone, go here: http://gazorpa.com/History.html For more information about filler in commercially prepared Naltrexone tablets, go here: http://gazorpa.com/LDNFillers.html Gee… anyone still awake? I wonder if anyone finds this as fascinating as I do... ZZZZZZZzzzzzzzzz…. Maureen (Gazorpa) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2006 Report Share Posted June 10, 2006 Thx Maureen. Very informative. I read an article about a new type of naltrexone that will be slow release, so I can only assume that all the other forms are fast release. They all appear to have lactose as a filler. > > asked: " would anyone know if the generic forms of naltrexone > (antaxone, nalorex, etc) are the same as or are as good as the Revia. > I make my own LDN and have been using Revia. I have some Nodict > tablets, they say 50mg naltrexone, but am not sure if they are the > same thing, or the generic forms. " > > Hi ! > > Good question. > > The word " generic " doesn't have much meaning for Naltrexone tablets > anymore. At this point, ALL forms of 50 or 100mg tablets of > naltrexone are generic. > > Here's the deal... > > The original (that is, the non-generic) 50mg Naltrexone Revia tablet > was manufactured by DuPont, starting in January 1995. > > Revia was actually a re-named version of DuPont's previous 50mg > Naltrexone tablet, brand-named Trexan, which had been FDA approved in > 1984 for opiate abuse. Dupont renamed Trexan when it was FDA approved > for alcohol abuse in 1995. > > In 1997, Dupont's market exclusivity agreement for Revia lapsed, which > means that other companies were now free to manufacture and market > generic naltrexone. > > In May 1998, the first generic version of ReVia was produced by Barr > Laboratories in Pomona NY. > > In 2001, Bristol Myers Squibb acquired DuPont Pharmaceuticals. > > In April 2002, Bristol Myers Squibb sold the ReVia brand-name rights > in the U.S. and Canada to Barr Laboratories, who had been making > " generic " naltrexone for four years. > > Right now, Barr manufactures ReVia in 50mg pills in the U.S and > Canada. Bristol Myers Squibb continues to market ReVia in countries > outside of the U.S. and Canada. > > You can see how the " original " vs " generic " pedigree begins to lose > its meaning in here somewhere.... > > Other versions of naltrexone are currently manufactured in the U.S. by > Eon Labs and Amide Pharmaceutical; Mallinckrodt Pharmaceuticals > manufactures 50mg and 100mg naltrexone pills in the U.S. under the > trade name Depade. > > Other 50mg versions of naltrexone are named Nalorex (manufactured by > Bristol-Myers Squibb in the UK); Nodict (manufactured by Sun Pharma in > India); Naltima (manufactured by INTAS in India), Narpan (by Duopharma > in Malaysia), Antaxone (by Pharmazam in Spain), Celupan (by Lacer in > Spain), Narcoral (by Siton in Italy), Nemexin (Bristol Myers Squibb in > Germany), as well as Revez, Naltrexona, and Naltrexonum. > > Although all of these brand-name tablets contain naltrexone, each > tablet also contains about 84% filler. Each manufacturer uses a > different combination of filler ingredients. It's the filler, rather > than the naltrexone itself, which accounts for differences in patient > reactions to the various brands. > > For more information about the history of Naltrexone, go here: > > http://gazorpa.com/History.html > > For more information about filler in commercially prepared Naltrexone > tablets, go here: > > http://gazorpa.com/LDNFillers.html > > Gee… anyone still awake? I wonder if anyone finds this as fascinating > as I do... > > ZZZZZZZzzzzzzzzz…. > > Maureen > (Gazorpa) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2006 Report Share Posted June 11, 2006 are the tablets even scored?cyndiOn Jun 10, 2006, at 10:33 PM, wrote:There are many folks who make their own LDN from naltrexone tablets with less than 'very accurate' measuring devices, I would imagine a pharmacist would/should have the necessary measuring devices to be somewhat more accurate, after all, they are measuring only 3-4.5mg's of naltrexone powder to mix with filler. A naltrexone tablet is around 300mg's I think(could be more or less), at least those of us who make it ourselves are dealing with 18-27mg doses(could be more or less), not 3-4.5 doses. I would need quite an expensive scale to measure that kind of dose. It even states on the lowdosenaltrexne.org site that some pharmacists make LDN out of naltrexone tablets. If your pharmacist cant figure out how to dose out a 50mg naltrexone tablet into 3-4.5 mg doses, better get a new pharmacist! :0) > > > ...from what I understand, there ARE some pharmacists who make LDN> > from naltrexone tablets. And, not trying to be a smarta**, but how Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2006 Report Share Posted June 11, 2006 No, maybe just one score down the middle. Goodshape had/has a method to figure out the right dosage using a bead glued to a coffee stirrer. If you pulverize the naltrexone tablet and fill the bead with the powder, he determined, using an expensive scale, that this was equal to 3-4.5 mg depending on where the fill landed inside the bead. Even though this method isnt very accurate in my opinion, it allowed you to get a 'fresh' dose of LDN each evening, since there is a concern that naltrexone loses some of it's potency when it sits in water for a length of time. Regardless, the liquid method is the way I measure it, I feel it is the most accurate. > > > > > > > ...from what I understand, there ARE some pharmacists who make > > LDN > > > > from naltrexone tablets. And, not trying to be a smarta**, but > > how > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2006 Report Share Posted June 11, 2006 of course Goodshape has a method-i would expect nothing less of him. I did ask one of our students to look up the solubility for me. I'm just really curious. it all has to do with molecules and chemistry and all that -and then explain to me so i can explain it to you guys. how much does this cost as opposed to just getting a prescription and getting it filled? is it a matter of pride? independence? i'm not being critical i'm just curiouscyndiOn Jun 11, 2006, at 11:31 AM, wrote:No, maybe just one score down the middle. Goodshape had/has a method to figure out the right dosage using a bead glued to a coffee stirrer. If you pulverize the naltrexone tablet and fill the bead with the powder, he determined, using an expensive scale, that this was equal to 3-4.5 mg depending on where the fill landed inside the bead. Even though this method isnt very accurate in my opinion, it allowed you to get a 'fresh' dose of LDN each evening, since there is a concern that naltrexone loses some of it's potency when it sits in water for a length of time. Regardless, the liquid method is the way I measure it, I feel it is the most accurate.> > > There are many folks who make their own LDN from naltrexone tablets> > with less than 'very accurate' measuring devices, I would imagine a> > pharmacist would/should have the necessary measuring devices to be> > somewhat more accurate, after all, they are measuring only 3-4.5mg's> > of naltrexone powder to mix with filler. A naltrexone tablet is> > around 300mg's I think(could be more or less), at least those of us> > w Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2006 Report Share Posted June 11, 2006 Making my own LDN costs me about 1-2 dollars per tablet, of which I can make about 14-15 doses(I use 3mg), so approximately 2-4 dollars per month. No filler to be concerned with, nobody filling the script to screw it up. Pride, independence??, what are you talking about? > > > > > > > There are many folks who make their own LDN from naltrexone > > tablets > > > > with less than 'very accurate' measuring devices, I would > > imagine a > > > > pharmacist would/should have the necessary measuring devices to > > be > > > > somewhat more accurate, after all, they are measuring only 3- > > 4.5mg's > > > > of naltrexone powder to mix with filler. A naltrexone tablet is > > > > around 300mg's I think(could be more or less), at least those of > > us > > > > w > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2006 Report Share Posted June 11, 2006 ...and, by the way, to save you and me some time. The naltrexone never really dissolves completely, thats why it is a good idea to shake the liquid a little before taking it. I know that sounds pretty simplistic, but I really dont need a lesson in molecules and chemistry. :0) > > > > > > > There are many folks who make their own LDN from naltrexone > > tablets > > > > with less than 'very accurate' measuring devices, I would > > imagine a > > > > pharmacist would/should have the necessary measuring devices to > > be > > > > somewhat more accurate, after all, they are measuring only 3- > > 4.5mg's > > > > of naltrexone powder to mix with filler. A naltrexone tablet is > > > > around 300mg's I think(could be more or less), at least those of > > us > > > > w > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 12, 2006 Report Share Posted June 12, 2006 My suggestion is that unless we have accurate balances, accurate pipets, and darn good laboratory technique, hire the compounding out. I've worked full time for several years in labs that do testing on FDA approved drugs. Have a pharmacist prepare the LDN for us. They have the tools and technique. If we place the LDN is water, the stability will likely be compromised. Water, H2O, has some exposed electrons on the oxygen atom. These electrons have a habit of inserting themselves into other molecules. If a liquid dose is made, store it in the fridge for better stability. Just taking a Scientific Wild Ass Guess (SWAG), I wouldn't reccomend storing the aqueous dose longer than 2 weeks (that's stored in the 5C fridge) According to the United States Pharmacopoeia (USP), any drug on the market has to be 90 - 110% of the label claim. So, a 50mg Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical ingredient (API), The tablet itself likely weighs about 300mg. The extra material is filler. What that filler is varies from manufacturer to manufacturer and maybe even lot to lot. If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If we are confident was can prepare dose after dose of LDN, all +/- 0.3 milligrams (0.0003g), then by all means make the stuff using measuring cups and coffee cans. If we are not confident about repeatedly making drug doses to + / - 0.00003g, then hire the work out to a compounding pharmacist. My $0.02 __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 12, 2006 Report Share Posted June 12, 2006 Thank you, I keep mine in the fridge, and it lasts just a little longer than 2 weeks, so I think I'm safe. I realize this isnt a perfect way to do it, and I also realize that where ones own health is concerned, one shouldnt mess around with experiments, but I'm doing ok so far, I've been using LDN for a few years now with no progression, and I'm saving a bunch of money. I guess it's a personal choice. > > My suggestion is that unless we have accurate balances, accurate pipets, and darn good laboratory technique, hire the compounding out. I've worked full time for several years in labs that do testing on FDA approved drugs. Have a pharmacist prepare the LDN for us. They have the tools and technique. > > If we place the LDN is water, the stability will likely be compromised. Water, H2O, has some exposed electrons on the oxygen atom. These electrons have a habit of inserting themselves into other molecules. If a liquid dose is made, store it in the fridge for better stability. Just taking a Scientific Wild Ass Guess (SWAG), I wouldn't reccomend storing the aqueous dose longer than 2 weeks (that's stored in the 5C fridge) > > According to the United States Pharmacopoeia (USP), any drug on the market has to be 90 - 110% of the label claim. So, a 50mg Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical ingredient (API), The tablet itself likely weighs about 300mg. The extra material is filler. What that filler is varies from manufacturer to manufacturer and maybe even lot to lot. > > If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If we are confident was can prepare dose after dose of LDN, all +/- 0.3 milligrams (0.0003g), then by all means make the stuff using measuring cups and coffee cans. If we are not confident about repeatedly making drug doses to + / - 0.00003g, then hire the work out to a compounding pharmacist. > > My $0.02 > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 12, 2006 Report Share Posted June 12, 2006 This has been quoted before. I'm curious if this is first hand information and if not does anyone have first hand info. about the water solubility of naltrexone? I tried to confirm this and couldn't. I have 2 Merck Index books (Indices?), 7th Edition, 1960, which doesn't list naltrexone at all and 11th Edition, 1989, which lists naltrexone but, strangely, no solubilities for it. Kennard wrote: >The naltrexone dissolves completely. The Filler does not entirely >dissolve. > >(This was from a pharmacist in the UK as quoted in the MeSsenger in >April) >http://www.ldnresearchtrust.org/Newsletter/April%203rd%202006.pdf > " Not to make this too complicated, the more soluble something is, the >more likely it is to stay dissolved, and form a uniform liquid. >Naltrexone is soluble in excess of 100mg per millilitre of water; i.e. >you can take 100mg of naltrexone (one hundred times the concentration >of LDN liquid) and dissolve it in ONE MILLILITRE of water. Naltrexone >liquid (LDN liquid), once prepared, has the same concentration of >naltrexone in the top 10ml as it does in the bottom of the bottle. " >J S DICKSON MRPharmS BSC (Hons) > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 12, 2006 Report Share Posted June 12, 2006 HIya Where do you get your Naltrexone/ReVia? I understand it's not listed on Medsmex but I haven't checked recently. thanks mjh"The Basil Book"http://foxhillfarm.us/FireBasil/ Re: Generic naltrexone Posted by: "" davizona@... davizona2000 Sun Jun 11, 2006 8:06 pm (PST) Thank you, I keep mine in the fridge, and it lasts just a little longer than 2 weeks, so I think I'm safe. I realize this isnt a perfect way to do it, and I also realize that where ones own health is concerned, one shouldnt mess around with experiments, but I'm doing ok so far, I've been using LDN for a few years now with no progression, and I'm saving a bunch of money. I guess it's a personal choice. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2006 Report Share Posted June 13, 2006 Once again, (can you hear the applause!) Bravo!! Very intriguing...Sir Real <alrightguy123@...> wrote: No one has likely done any stability studies of 3mg aqueous doses of naltrexone. Before a drug goes on the market, the company has to perform "registration stability" studies to prove that the marketed product will last two years on a typical shelf. A typical shelf is considered to be 25C/60% RH (relative humidity). The manufacturer typically does not test past 2 years. The reason testing is not performed at greater than 2 years is that every test on a product takes considerable resources. The product has to be stored under carefully controlled and monitored temperature and humidity conditions. All of the temp and humidity data of the storage areas has to be kept for the rest of time. Every test is potentially a liability to the company. If a marketed product is on a shelf longer than 2 years, what does the packaging look like? The box will be faded and covered with dust. Get it out of there so the pharmacy shelves are not plugged up with old product. The potency of the aqueous solution likely does not exist, anywhere. My two week suggestion comes from testing other products. I get the bulk API and make solutions of accurate concentration, typically in organic (ethanol or acetonitrile) / water solutions. Stability studies are performed on these standards so we know how long they can be used. If the stability of aqueous naltrexone were to be performed, it would likely be tested by High Performance Liquid Chromatography (HPLC). These instruments cost $30k to $70k USD. All of the data has to be kept from several years to forever. Just to argue, or in a more PC way, engage in critical thinking........ If someone just had a particularly long time between exacerbations and excaberations were our only indicator of product stability, even a placebo would show good stability. I'm not trying to me mean, difficult, or pompous, I look at lab procedures and or lab data in very critical ways. This includes the studies for the CRABs too (don't get me started....). After reading the LDN list for a while now, this is an area I feel qualified to chip in on and share 17 or 18 yrs of professional experience. PS: glassware that accurately measures volume can be purchased from Sargent Welch or American Science and Surplus. Make sure whatever you get is brand spanking new glassware if you intend to make things for human consumption. I'll be quiet now Sir Real __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2006 Report Share Posted June 13, 2006 In my opinion, since LDN is not a "heavy", side effect ridden drug, & since the precise optimum dose for any particular individual can really only be found by trial & error anyway, I believe that it is inappropiate/unnecessary to get too obsessive about the need for the ultimate degree of accuracy in dosage: I believe that, provided that one takes reasonable care to carry out the procedure as accurately as possible, minute variations are likely to be insignificant/unnoticeable in the larger scheme of things: This has been my experience over the last 9 months or so, at any rate. (-Using Revia from MedsMex.) eg. -Who is to say that actually exactly 3mg is better than 2.7mg? -or3.3mg? -For any particular individual?.................Or perhaps 3.2mg would be best?.........Who really knows?.........-Could be that one`s exact optimum dose on any particular day is affected by what one is eating/thinking/sleeping & so on?! Personally, I am one of those who uses half a Revia Tablet at a time, which is enough to make 8 doses of 3mg, (ie. 8 doses of 3ml when mixed with water.) -Just 8 days worth, this is believed to be an OK length of time. It`s now over 2 years 3months since I commenced taking LDN; prior to using Revia from MedsMex, I was using Skips, & prior to that, Irmats. I found all three sources to be fine! (For your info, a while back, there was even talk here that Revia from MedsMex, dissolved in water, might be a more potent source of LDN than that made up by the pharmas! -Personally, I don`t have an opinion on this..........) HOWEVER! I do think that it is not particularly helpful to alarm people by raising theoretical doubts about the practicalities of a source of LDN that many people in the real world have been finding beneficial for quite some time now! I think that this simply adds the additional & unnecessary stress of doubts & worries to those who may wish to commence taking LDN but may have been unable to obtain a script or would prefer or need to find the most economical source. Let`s hope that MedsMex get re-stocked soon! Best Wishes to all, Gerald (-SPMS) [low dose naltrexone] Re: Generic naltrexone My suggestion is that unless we have accurate balances, accurate pipets, and darn good laboratory technique, hire the compounding out. I've worked full time for several years in labs that do testing on FDA approved drugs. Have a pharmacist prepare the LDN for us. They have the tools and technique. If we place the LDN is water, the stability will likely be compromised. Water, H2O, has some exposed electrons on the oxygen atom. These electrons have a habit of inserting themselves into other molecules. If a liquid dose is made, store it in the fridge for better stability. Just taking a Scientific Wild Ass Guess (SWAG), I wouldn't reccomend storing the aqueous dose longer than 2 weeks (that's stored in the 5C fridge) According to the United States Pharmacopoeia (USP), any drug on the market has to be 90 - 110% of the label claim. So, a 50mg Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical ingredient (API), The tablet itself likely weighs about 300mg. The extra material is filler. What that filler is varies from manufacturer to manufacturer and maybe even lot to lot. If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If we are confident was can prepare dose after dose of LDN, all +/- 0.3 milligrams (0.0003g), then by all means make the stuff using measuring cups and coffee cans. If we are not confident about repeatedly making drug doses to + / - 0.00003g, then hire the work out to a compounding pharmacist. My $0.02 __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2006 Report Share Posted June 14, 2006 Hi, -No; please note that I said HALF of a Revia tablet, ie .-25mg of naltrexone, add 25 ml of water & when mixed, there will be enough liquid LDN for 8 doses of 3mg/ml. Further, for the sake of clarity regarding dosage accuracy; I was NOT advocating unnecessary sloppiness! -I was simply attempting to make a point & add a realistic, ( & hopefully balanced!) perspective to the topic: I use a syringe to carefully measure out the the 3 ml & I believe that this is pretty accurate way of doing things: -Certainly way, WAY more precise than the wide parameters of between 2.5 & 4.5 that you indicated that you personally are happy with! Best Wishes, Gerald [low dose naltrexone] Re: Generic naltrexone > > > > > > My suggestion is that unless we have accurate balances, accurate > pipets, and darn good laboratory technique, hire the compounding > out. I've worked full time for several years in labs that do testing > on FDA approved drugs. Have a pharmacist prepare the LDN for us. > They have the tools and technique. > > > > If we place the LDN is water, the stability will likely be > compromised. Water, H2O, has some exposed electrons on the oxygen > atom. These electrons have a habit of inserting themselves into > other molecules. If a liquid dose is made, store it in the fridge > for better stability. Just taking a Scientific Wild Ass Guess > (SWAG), I wouldn't reccomend storing the aqueous dose longer than 2 > weeks (that's stored in the 5C fridge) > > > > According to the United States Pharmacopoeia (USP), any drug on > the market has to be 90 - 110% of the label claim. So, a 50mg > Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical > ingredient (API), The tablet itself likely weighs about 300mg. The > extra material is filler. What that filler is varies from > manufacturer to manufacturer and maybe even lot to lot. > > > > If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If > we are confident was can prepare dose after dose of LDN, all +/- > 0.3 milligrams (0.0003g), then by all means make the stuff using > measuring cups and coffee cans. If we are not confident about > repeatedly making drug doses to + / - 0.00003g, then hire the work > out to a compounding pharmacist. > > > > My $0.02 > > __________________________________________________ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2006 Report Share Posted June 14, 2006 Gotcha, I read that, sorry. > > > > > > In my opinion, since LDN is not a " heavy " , side effect ridden > > drug, & since the precise optimum dose for any particular > individual > > can really only be found by trial & error anyway, I believe that > it > > is inappropiate/unnecessary to get too obsessive about the need > for > > the ultimate degree of accuracy in dosage: I believe that, > provided > > that one takes reasonable care to carry out the procedure as > > accurately as possible, minute variations are likely to be > > insignificant/unnoticeable in the larger scheme of things: This > has > > been my experience over the last 9 months or so, at any rate. (- > > Using Revia from MedsMex.) > > > > > > eg. -Who is to say that actually exactly 3mg is better than > > 2.7mg? -or3.3mg? -For any particular > individual?.................Or > > perhaps 3.2mg would be best?.........Who really knows?.........- > > Could be that one`s exact optimum dose on any particular day is > > affected by what one is eating/thinking/sleeping & so on?! > > > > > > Personally, I am one of those who uses half a Revia Tablet at a > > time, which is enough to make 8 doses of 3mg, (ie. 8 doses of 3ml > > when mixed with water.) -Just 8 days worth, this is believed to be > > an OK length of time. > > > > > > > > > It`s now over 2 years 3months since I commenced taking LDN; > > prior to using Revia from MedsMex, I was using Skips, & prior to > > that, Irmats. I found all three sources to be fine! > > > > > > (For your info, a while back, there was even talk here that > Revia > > from MedsMex, dissolved in water, might be a more potent source of > > LDN than that made up by the pharmas! -Personally, I don`t have an > > opinion on this..........) > > > > > > HOWEVER! I do think that it is not particularly helpful to > alarm > > people by raising theoretical doubts about the practicalities of a > > source of LDN that many people in the real world have been finding > > beneficial for quite some time now! > > > I think that this simply adds the additional & unnecessary > stress > > of doubts & worries to those who may wish to commence taking LDN > > but may have been unable to obtain a script or would prefer or > need > > to find the most economical source. > > > > > > Let`s hope that MedsMex get re-stocked soon! > > > > > > Best Wishes to all, > > > > > > Gerald (-SPMS) > > > [low dose naltrexone] Re: Generic naltrexone > > > > > > > > > My suggestion is that unless we have accurate balances, > accurate > > pipets, and darn good laboratory technique, hire the compounding > > out. I've worked full time for several years in labs that do > testing > > on FDA approved drugs. Have a pharmacist prepare the LDN for us. > > They have the tools and technique. > > > > > > If we place the LDN is water, the stability will likely be > > compromised. Water, H2O, has some exposed electrons on the oxygen > > atom. These electrons have a habit of inserting themselves into > > other molecules. If a liquid dose is made, store it in the fridge > > for better stability. Just taking a Scientific Wild Ass Guess > > (SWAG), I wouldn't reccomend storing the aqueous dose longer than > 2 > > weeks (that's stored in the 5C fridge) > > > > > > According to the United States Pharmacopoeia (USP), any drug > on > > the market has to be 90 - 110% of the label claim. So, a 50mg > > Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical > > ingredient (API), The tablet itself likely weighs about 300mg. > The > > extra material is filler. What that filler is varies from > > manufacturer to manufacturer and maybe even lot to lot. > > > > > > If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. > If > > we are confident was can prepare dose after dose of LDN, all +/- > > 0.3 milligrams (0.0003g), then by all means make the stuff using > > measuring cups and coffee cans. If we are not confident about > > repeatedly making drug doses to + / - 0.00003g, then hire the work > > out to a compounding pharmacist. > > > > > > My $0.02 > > > __________________________________________________ > > > Quote Link to comment Share on other sites More sharing options...
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