Guest guest Posted April 10, 2006 Report Share Posted April 10, 2006 This is from the LDN website: The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime each night is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production. To me that sounds like you should be taking LDN before 2 a.m... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2006 Report Share Posted August 1, 2006 The rationale is based on Dr Bihari's findings, which are explained on his website. This paragraph explains why it is taken at that time: 'The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime.' It has nothing to do with 'night shifts' or work patterns. Most people take it at this time because for most people this IS bedtime. LarryGC works a night shift and still takes his LDN at that prescribed time, he's doing great.>> Folks,> I don't understand something and it's been bugging me ever since I started> taking LDN. My problem is about taking it at some arbitrary, specific time> of day rather than a biological based time as I first thought e.g., "Bed> Time".> > Saying to take it between 7 and 11 P.M. makes almost no sense. Are the> instructions for EDT or PDT or something else. If EDT, what does a person> do who lives in the Antarctic or who works a graveyard shift or something> else? I think it makes more sense to take it at "bedtime" i.e., when you go> to bed. Your Circadian rhythm makes more sense to determine times to take> medicines. The description about why doctors think LDN works is based on> your sleep cycle not an arbitrary time of the day.> > It means LDN will work for anyone without regard to their work schedule,> where they live or under what physical conditions they live (e.g., in an> underground bunker). Does anyone have a problem with taking LDN at Bedtime> vs. at a specific time of day and do you have any rationale for that?> > Larry> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2006 Report Share Posted August 1, 2006 > > Folks, > I don't understand something and it's been bugging me ever since I started > taking LDN. My problem is about taking it at some arbitrary, specific time > of day rather than a biological based time as I first thought e.g., " Bed > Time " . > > Saying to take it between 7 and 11 P.M. makes almost no sense. Are the > instructions for EDT or PDT or something else. If EDT, what does a person > do who lives in the Antarctic or who works a graveyard shift or something > else? I think it makes more sense to take it at " bedtime " i.e., when you go > to bed. Your Circadian rhythm makes more sense to determine times to take > medicines. The description about why doctors think LDN works is based on > your sleep cycle not an arbitrary time of the day. > > It means LDN will work for anyone without regard to their work schedule, > where they live or under what physical conditions they live (e.g., in an > underground bunker). Does anyone have a problem with taking LDN at Bedtime > vs. at a specific time of day and do you have any rationale for that? > > Larry > Dear Larry, I am a patient of Dr. Bihari and here is what I understand the explanation to be. First of all, the best time to take LDN is 11:00 PM. That is for the time zone you are in. You can take LDN between 9:00 PM and 2:00 AM. You do not have to go to sleep for it to be effective. Those times are chosen because that is a peek period for the production of endorphins, even if you are not asleep, and hence the LDN's effect is greater. In essense, the time is not arbitrary but selected because it corresponds with a time when endorphin production is highest. He chose that time frame based upon his research. As for the issue about the Artic, I would not be concerned unless you live up there... Dr. Bihari's research and results are based upon patients taking LDN in the above time frame so I would not change the time you take it without a very good reason. Hope that helps. Best, Andy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2006 Report Share Posted August 1, 2006 > > Folks, > I don't understand something and it's been bugging me ever since I started > taking LDN. My problem is about taking it at some arbitrary, specific time > of day rather than a biological based time as I first thought e.g., " Bed > Time " . > > Saying to take it between 7 and 11 P.M. makes almost no sense. Are the > instructions for EDT or PDT or something else. If EDT, what does a person > do who lives in the Antarctic or who works a graveyard shift or something > else? I think it makes more sense to take it at " bedtime " i.e., when you go > to bed. Your Circadian rhythm makes more sense to determine times to take > medicines. The description about why doctors think LDN works is based on > your sleep cycle not an arbitrary time of the day. > > It means LDN will work for anyone without regard to their work schedule, > where they live or under what physical conditions they live (e.g., in an > underground bunker). Does anyone have a problem with taking LDN at Bedtime > vs. at a specific time of day and do you have any rationale for that? > > Larry > ========= Go to the LDN website and especially read the Further Q and A page there, it will answer some of your questions about why LDN is taken between the hours of 9pm and 3am no matter what time zone one is in or shift a person works. LDN website http://www.ldninfo.org Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2006 Report Share Posted August 1, 2006 That FQA question was MINE I work 12-8AM and I didn't know if I should take it at "bed time" or still, between 9pm and 3am. However, MY "bed time" is hard to call... I don't really HAVE a "bed time". I lay down around 7pm or so every day for 4-4 1/2 hours, I also sometimes lay down for a nap around 10am for 3 hours. I have been taking my LDN around 1AM ever since I started back in 2003. My first 10 days on LDN I was on a 'normal' 'day' schedule, so I started taking it at 1AM at that point, which was 'bed time' then. When I went back to my 12-8am schedule I continued to take it at 1AM, but that was when I was first getting my day started. Given my early days journaling, I'd say LDN was working for me just fine that way. Given 3 1/4 years now doing it this way, it's working GREAT. The Theory is that LDN works on the human body during the Pre-Dawn hours, which is based >Where< you are, not When 'you' sleep. If you go to most any chiropractic office you may find a chart that shows times of day when to massage certain parts of the body to help certain bodily functions. This has to do with the rotation of the Earth cycle, not an individual's sleeping cycle. Took a while for it all to make sense, but it makes sense. It also makes sense why some people "Wake Up" at or near 4AM when first getting started. I know someone who kept getting sick every few weeks and decided to try LDN for a few days. They took it for 30 days, after 4 days on it, whatever they kept getting had gone away (and never came back!). Their feedback was that at 4AM nearly Every Day on LDN, their eyes would open up AT 4AM, Every Day.... many days they couldn't get back to sleep. Given the short study in Germany, with people taking LDN during the daylight hours, it showed that LDN is indeed most effective when taking during the 9pm-3am timeframe. There IS something to it. If we're going to take the LDN, we may as well follow Protocol, no? Works for me! I wouldn't be doing all I'm doing otherwise. I just got back from 19 of 28 days (16 of them in a row) camping and am heading out again for another 5, and then in a few weeks another 5. The strangest thing is, in the middle of those 16 days in a row, for the last 3 years, has been when I felt the best each year (scale 1-10, nearly 10). *of course, JMHO [low dose naltrexone] Re: When to take LDN >> Folks,> I don't understand something and it's been bugging me ever since I started> taking LDN. My problem is about taking it at some arbitrary, specific time> of day rather than a biological based time as I first thought e.g., "Bed> Time".> > Saying to take it between 7 and 11 P.M. makes almost no sense. Are the> instructions for EDT or PDT or something else. If EDT, what does a person> do who lives in the Antarctic or who works a graveyard shift or something> else? I think it makes more sense to take it at "bedtime" i.e., when you go> to bed. Your Circadian rhythm makes more sense to determine times to take> medicines. The description about why doctors think LDN works is based on> your sleep cycle not an arbitrary time of the day.> > It means LDN will work for anyone without regard to their work schedule,> where they live or under what physical conditions they live (e.g., in an> underground bunker). Does anyone have a problem with taking LDN at Bedtime> vs. at a specific time of day and do you have any rationale for that?> > Larry>=========Go to the LDN website and especially read the Further Q and A page there, it will answer some of your questions about why LDN is taken between the hours of 9pm and 3am no matter what time zone one is in or shift a person works.LDN websitehttp://www.ldninfo.org Quote Link to comment Share on other sites More sharing options...
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