Glutamate identified as predictor of disease progression in multiple sclerosis

[Guest guest]

I am posting this lengthy message because I think it is so impolrtant. Excess

glutamaine slso damages the mitochondria. Please share your thoughts.

http://www.eurekalert.org/pub_releases/2009-04/uoc--gia042809.ph

University of California - San Francisco

Glutamate identified as predictor of disease progression in multiple sclerosis

http://www.naturalnews.com/020550.html

Dr. Blaylock: Those would include leucine, isoleucine and lysine. They would

compete for the same carrier system, so that would slow down absorption. There

are a lot of things that act as glutamate blockers. You know, like silimarin,

curcumin and ginkgo biloba. These things are known to directly block glutamate

receptors and reduce excitotoxicity. Curcumin is very potent. Most of your

flavonoids.

Magnesium is particularly important, because magnesium can block the MNDA

glutamate type receptor. That's its natural function, so it significantly

reduces toxicity. Vitamin E succinate is powerful at inhibiting excitotoxicity,

as are all of your antioxidants. They found combinations of B vitamins also

block excitotoxicity.

http://www.naturalnews.com/016646.html

Protecting the Brain from a Glutamate Storm

It is known that phosphatidylserine is a natural glutamate blocker. It has also

been shown to improve cell membrane stability and fluidity.he next task was to

test whether clearing excess glutamate from the brain by this method would

protect the brain from glutamate's deleterious effects. In experiments in rats

with traumatic brain injury, a natural compound called This method aims to

protect the brain by going to the root of the problem: preventing the glutamate

storm. oxaloacetate, which reacts with the blood enzyme glutamate-oxaloacetate

transaminase, was used to scavenge blood glutamate.

http://www.dana.org/news/cerebrum/detail.aspx?id=7376

Removing excess glutamate

The potentially therapeutic properties of ceftriaxone for ALS have little to do

with its antibiotic effects but instead result from its ability to increase the

number of glutamate transporters. Glutamate transporters are proteins that

vacuum up the excitatory neurotransmitter glutamate. Normally, glutamate acts to

excite nerves so that electrical signals can travel from one to the next. Too

much glutamate has a toxic effect on nerve cells and has been implicated in

neurodegenerative diseases such as ALS, Huntington's disease, Alzheimer's

disease, epilepsy and stroke. Removing glutamate through the transporter

prevents nerve damage caused by excessive amounts of glutamate. " Increasing the

glutamate transporter expression and removing the excess glutamate is

essentially like turning on a fan to clear a smoke-filled room, " says Dr.

Rothstein.

As part of the Drug Screening Consortium, Dr. Rothstein found that 15 drugs from

the penicillin family, named beta lactams, increased glutamate transport in

cultures of spinal cord slices and therefore increased removal of this

excitatory neurotransmitter. Because this class of antibiotics can increase

removal of excess glutamate, researchers hypothesized this could lead to better

drug treatment therapies for neurodegenerative disorders like ALS.

http://www.ninds.nih.gov/news_and_events/news_articles/news_article_ALS_ceftriax\

one.htm