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,Dave R.,Liz

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Hi ;

These 5 articles provide a pretty good summary of the mechanisms of

action of Urso and the promising positive effects of high-dose Urso

on delaying disease progression in PSC, and in chemoprevention of

colorectal cancer:

Angulo P 2002 Use of ursodeoxycholic acid in patients with liver

disease. Curr. Gastroenterol. Rep. 4: 37-44

Harnois DM, Angulo P, nsen RA, Larusso NF, Lindor KD 2001 High-

dose ursodeoxycholic acid as a therapy for patients with primary

sclerosing cholangitis. Am. J. Gastroenterol. 96: 1558-1562

SA, Bansi DS, Hunt N, Von Bergmann K, Fleming KA, Chapman RW

2001 A preliminary trial of high-dose ursodeoxycholic acid in primary

sclerosing cholangitis. Gastroenterology 121: 900-907

Pardi DS, Loftus EV Jr, Kremers WK, Keach J, Lindor KD 2003

Ursodeoxycholic acid as a chemopreventive agent in patients with

ulcerative colitis and primary sclerosing cholangitis.

Gastroenterology 124: 889-893

Paumgartner G, Beuers U 2002 Ursodeoxycholic acid in cholestatic

liver disease: mechanisms of action and therapeutic use revisited.

Hepatology 36: 525-531

If you visit our PSC Literature website:

http://home.insightbb.com/~rhodesdavid/

and then scroll down the left " Menu " and click on " urso " you'll find

each of these references listed with individual links to their PubMed

abstracts. I can provide you with full text of the Harnois et al and

Paumgartner and Beuers papers if you would like. Just let me know

your e-mail address and I will send them as file attachments.

Best regards,

Dave

(father of (18 yr); dx PSC 07/03; dx UC 08/03)

>

> Dave R. Thanks for the email on Urso.I may need

> to do that get articles about why I should be on

> Urso.

>

> in Ga.

>

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