Guest guest Posted January 31, 2005 Report Share Posted January 31, 2005 Thank you stephen, I will ask my doctor about Danazol. The itches are quite out of controll today. Dziemian wrote: My itching was very similar, it is definitely not in your head. In my case the itching was the worst part of my PSC. I currently take DANAZOL for itching, it is the only thing that has touched the itching for me. Unfortunately itching is different in each person. What works for one person doesn't work for the next. Rifampin is another drug that works for some people. Antihistamines (benadryl or prescription strength) work reasonably well for some people, but the major problem with these are they cause drowsiness. In my case they didn't help my itching they just made me so tired that I could sleep through the night, which was helpful at times. You'll have to work with your Dr. to find what works for you. The only way is trial and error. In my case I tried over a dozen different drugs before I found what worked for me. You can help relieve some of itching by taking cool showers and keeping your skin from getting too dry. Hope this helps. I can understand how frustrating it is to be so itchy that you can't sit still or even sleep through the night. Good luck. Steve, PSC 92, UC 93-- In , "heather" <trikiniki5@y...> wrote:> > Question: The itching i feel is like pins and needles all over, on > my fingers, arms, face. Is this the same itching you feel or is it > all in my head.can I take anything for it?> > from ohio__________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2005 Report Share Posted March 10, 2005 I know itching is a common discussed topic and I have one more question, especially for those in early stages of the disease. I have had very violent itch attacks, primarily in the winter when my skin is dry and I get hot. The attacks went away if I cooled down-taking off a sweater for example. The itching would flare up very quickly and go away quickly too. I have not had these attacks the last couple winters. My Hep doesn't think my itching was related to my liver because the itching would come and go so easily based on how warm I was. Has anyone else experienced the itch this way or is he right and was it likely caused by something else? Anyone have a comment? in Cleveland wrote: Hello ;Welcome to the group. My son was diagnosed with PSC in mid-2003, and began itching in early 2004. We thought this might be due to ursodiol use, as this is listed as a possible side-effect of ursodiol. We tried change the dose, and source of ursodiol (switching from Actigall to URSO 250), but this didn't seem to improve things. He tried Atarax, but this seemed to be without effect. His hepatologist then prescribed Rifampin (150 mg twice daily), and this has had a marked effect on diminishing his itching. Rifampin is an inducer of the pregnane X receptor in the liver; a nuclear transcription factor (sort of like a mster switch), that regulates the expression and levels of a number of enzymes involved in bile metabolism and transport. It's thought that in certain types of inflammatory bowel disease (ulcerative colitis in particular), that this pregnane X receptor is down-regulated:Langmann T, Moehle C, Mauerer R, Scharl M, Liebisch G, Zahn A, Stremmel W, Schmitz G 2004 Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology 127: 26-40. Perhaps rifampin is overcoming this dysregulation, and allowing for better bile metabolism and transport in PSC with UC?Others in the group have already mentioned cholestyramine as an alternative medication.Best regards,Dave (father of (19); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2005 Report Share Posted March 10, 2005 Yes - has not recurred since CBD dilatation and stenting, however. After a run (in the winter), my skin would be red and blotchy (chest, back, thighs). I don't recall it itching, however. It no longer does that (since stenting). Arne53 - UC 9/77 - PSC 4/00Alive and (mostly) well in Minnesota From: Drasner I know itching is a common discussed topic and I have one more question, especially for those in early stages of the disease. I have had very violent itch attacks, primarily in the winter when my skin is dry and I get hot. The attacks went away if I cooled down-taking off a sweater for example. The itching would flare up very quickly and go away quickly too. I have not had these attacks the last couple winters. My Hep doesn't think my itching was related to my liver because the itching would come and go so easily based on how warm I was. Has anyone else experienced the itch this way or is he right and was it likely caused by something else? Anyone have a comment? in Cleveland Quote Link to comment Share on other sites More sharing options...
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