Re: we had our video yesterday

[Guest guest]

actually it is more common that the mother does have the disease. If it were me I would allow the testing. If your son has Mito it is a very good chance that you do too.

Hugs

O

Mito Mommy smiling with tear filled eyes, holding on to Gods hand tightly, knowing He holds us in the palm of His hands and won't let go!

[Guest guest]

why would you say that if someone's son has mito it is very likely that

his mom does too? Never heard that comment made before.

[Guest guest]

Because a good portion of Mito is Maternal linked. Mom can be carrier or actually affected. Rick Boles is studying this right now.

Mito Mommy smiling with tear filled eyes, holding on to Gods hand tightly, knowing He holds us in the palm of His hands and won't let go!

[Guest guest]

karen,. i am assuming still seeing you post that your decision was to remain

on this list..and if that is true i am truly happy that you are..i always

enjoy reading your posts and understand why all the recent hype may have

upset you..seems like the undercurrent has settled ~~ please stay!

bradleys mom~ linda

[Guest guest]

Thankyou It was the Mitoldies list that I was upset with, but yes my decision has been to stay as a quiet member there for a while. Thank you for caring!

Hugs

O

Mito Mommy smiling with tear filled eyes, holding on to Gods hand tightly, knowing He holds us in the palm of His hands and won't let go!

[Guest guest]

If the baby has a true mitochondrial disorder, then it most likely came from the Mom. It can't come from the Dad. I understand that there can be mitochondrial mutuations that don't come from the Mom, but I don't know the frequency of those.

All of it is so confusing anyway!

[Guest guest]

I need to clear something up here - please don't think I'm trying to correct

you, but I don't want people to be misinformed.

MOST mitochondrial disorders are not caused by mutations in the

mitochondrial DNA (which is inherited from the mother), but rather they are

caused by mutations in the nuclear DNA - which is inherited from both

parents. Even those disorders that are caused by mitochondrial DNA mutations

are not necessarily inherited from the mother. There are several mitochondrial

DNA disorders that are sporadic or where the mtDNA deletion/mutation is caused

by another gene in the nuclear DNA.

Terri

>From: Ginny581@...

>Reply-To: Mito

>To: Mito

>Subject: Re: we had our video yesterday

>Date: Mon, 19 Mar 2001 09:21:19 EST

>

>If the baby has a true mitochondrial disorder, then it most likely came

>from

>the Mom. It can't come from the Dad. I understand that there can be

>mitochondrial mutuations that don't come from the Mom, but I don't know the

>frequency of those.

>

>All of it is so confusing anyway!

_________________________________________________________________

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[Guest guest]

There are three ways you can get a mito disorder genetically.

One: Inherited from the mom in her mitochondria which are always

passed to the child. The child gets all mitochondria from the Mom.

Two: Inherited from the mom (but not through her mitochondria).

Passed the normal way through the RNA/DNA, and passed as a X-linked (female

linked) characteristic.

Three: From the Dad and the Mom, as a recessive gene which by some strangeness

occurred in two people who found each other. Very rare but does happen.

Four: Inherited as a dominant gene from either parent. In

which case the parent has it too and would be affected.

I don't get it all either but we've been working on this and this is

what I understand.

Ginny581@... wrote:

If the

baby has a true mitochondrial disorder, then it most likely came from

the Mom. It can't

come from the Dad. I understand that there can be

mitochondrial mutuations

that don't come from the Mom, but I don't know the

frequency of those.

All of it is so confusing

anyway!

http://www.umdf.org/support/listpolicy.html

[Guest guest]

Thanks, . That is helpful information.

Virginia

[Guest guest]

,

Just a quick word to say...there are also mito diseases that are

genetic, but not inherited at all. These are the de novo/spontaeous

mutation diseases like Pearsons and KSS.

, momma to

^^

PS & KSS

son wrote:

> There are three ways you can get a mito disorder genetically.

>

> One: Inherited from the mom in her mitochondria which are always

> passed to the child. The child gets all mitochondria from the Mom.

>

> Two: Inherited from the mom (but not through her mitochondria).

> Passed the normal way through the RNA/DNA, and passed as a X-linked

> (female linked) characteristic.

>

> Three: From the Dad and the Mom, as a recessive gene which by some

> strangeness occurred in two people who found each other. Very rare

> but does happen.

>

> Four: Inherited as a dominant gene from either parent. In which case

> the parent has it too and would be affected.

>

> I don't get it all either but we've been working on this and this is

> what I understand.

>

>

>

>

>

> Ginny581@... wrote:

>

>> If the baby has a true mitochondrial disorder, then it most likely

>> came from

>> the Mom. It can't come from the Dad. I understand that there can

>> be

>> mitochondrial mutuations that don't come from the Mom, but I don't

>> know the

>> frequency of those.

>>

>> All of it is so confusing anyway!

>>

>> http://www.umdf.org/support/listpolicy.html

>>

>>

[Guest guest]

My daughter Meghan (age 7) is the rare number three.

My husband and I each care a recessive gene and she

picked them both up. We have an older son age 10 (11

in August)and he is unaffected. Still not sure if he

may have the same recessive gene though which if he

married someone and that person had a recessive gene

then high possiblity of him having a child like his

sister. You are right everything is so complicated.

The third way that you described does happen. Thanks

for listening

--- son wrote:

> There are three ways you can get a mito disorder

> genetically.

>

> One: Inherited from the mom in her mitochondria

> which are always passed

> to the child. The child gets all mitochondria from

> the Mom.

>

> Two: Inherited from the mom (but not through her

> mitochondria). Passed

> the normal way through the RNA/DNA, and passed as a

> X-linked (female

> linked) characteristic.

>

> Three: From the Dad and the Mom, as a recessive gene

> which by some

> strangeness occurred in two people who found each

> other. Very rare but

> does happen.

>

> Four: Inherited as a dominant gene from either

> parent. In which case

> the parent has it too and would be affected.

>

> I don't get it all either but we've been working on

> this and this is

> what I understand.

>

>

>

>

>

> Ginny581@... wrote:

>

> > If the baby has a true mitochondrial disorder,

> then it most likely

> > came from

> > the Mom. It can't come from the Dad. I

> understand that there can be

> > mitochondrial mutuations that don't come from the

> Mom, but I don't

> > know the

> > frequency of those.

> >

> > All of it is so confusing anyway!

> >