Guest guest Posted January 11, 2005 Report Share Posted January 11, 2005 Thank you You have a great memory Take care Re: /Deb & female question > > > Dear and Deb; > > I saw this paper today, and thought you might be interested in it. > Although it deals with arthritis, I should imagine it might apply to > other autoimmune diseases such as PSC? > > Rheum Dis Clin North Am. 2005 Feb;31(1):19-27. > > Estrogens and arthritis. > > Cutolo M, Lahita RG. > > Research Laboratory, Division of Rheumatology, Department of > Internal Medicine, Universita degli Studi di Genova, Viale Benedetto > XV 6, 16132 Genova, Italy. > > Sex hormones seem to play an important role as modulators and > perpetuators of rheumatic disorders with autoimmune involvement, > such as rheumatoid arthritis or systemic lupus erythematosus. > Estrogens are implicated in the immune response as enhancers of the > humoral immunity. Sex hormones can exert local actions (paracrine) > in the tissues in which they are formed; an accelerated peripheral > metabolic conversion of upstream androgen precursors to estrogens > has been well-assessed. Local effects of sex hormones in autoimmune > rheumatic diseases seem to consist mainly of the modulation of cell > proliferation and cytokine production. All of these data further > suggest caution in exogenous estrogen administration in patients who > have autoimmune diseases. PMID: 15639053. > > Best regards, > > Dave > (father of (19); PSC 07/03; UC 08/03) > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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