Re: Spironolactone (contd.)?

[Guest guest]

Dear ;

A detailed description of spironolactone (aldactone) can be obtained

from the manufacturer:

http://www.pfizer.com/download/uspi_aldactone.pdf

When used for edema in adults, an effect might be seen in 5 days

[depending on the dose]:

" Edema in adults (congestive heart failure, hepatic cirrhosis,

or nephrotic syndrome). An initial daily dosage of 100 mg of

Aldactone administered in either single or divided doses is

recommended, but may range from 25 to 200 mg daily. When given as the

sole agent for diuresis, Aldactone should be continued for at least

five days at the initial dosage level, after which it may be adjusted

to the optimal therapeutic or maintenance level administered in

either single or divided daily doses. If, after five days, an

adequate diuretic response to Aldactone has not occurred, a second

diuretic which acts more proximally in the renal tubule may be added

to the regimen. Because of the additive effect of Aldactone when

administered concurrently with such diuretics, an enhanced diuresis

usually begins on the first day of combined treatment; combined

therapy is indicated when more rapid diuresis is desired. The dosage

of Aldactone should remain unchanged when other diuretic therapy is

added. "

When used for hypertension in adults, an effect might not be seen

until 2 weeks [depending on the dose]:

" Essential hypertension. For adults, an initial daily dosage of 50 to

100 mg of Aldactone administered in either single or divided doses is

recommended. Aldactone may also be given with diuretics which act

more proximally in the renal tubule or with other antihypertensive

agents. Treatment with Aldactone should be continued for at least two

weeks, since the maximum response may not occur before this time.

Subsequently, dosage should be adjusted according to the response of

the patient. "

Please read the warning and adverse reactions sections of this

document carefully.

Best regards,

Dave

(father of (19); PSC 07/03; UC 08/03)

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> I'm sure someone in this group has taken Spironolactone as some

> point. Generally, how long should it take to see some noticeable

> change? Thanks.

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