Re: Latest article on PSC

[Guest guest]

Thanks Dave. I find it both informative and scary to read these things.

I haven't heard about this Tacrolimus drug. Let's hope that it is

something that will help.

Lee

>

[Guest guest]

Dave,

Thanks for the hot off the press article. Too bad it doesn't discuss the medications/supplements that you have been researching, but I'm somewhat encouraged by the first paragraph where they state: "PSC has been an area of active research worldwide....." Here's hoping for more PSC research worldwide in 2005.

Ricky

PSC 2003

Latest article on PSC

Dear All;Here's the latest article on PSC (hot off the press!):World J Gastroenterol. 2005 Jan 7;11(1):7-16. Primary sclerosing cholangitis: Updates in diagnosis and therapy.Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van-Erpecum KJ, van-Berge-Henegouwen GP.Professor of Internal Medicine, Section of Internal Medicine, Department of Internal and Public Medicine (DIMIMP), University Medical School of Bari, P.zza G. Cesare 11, 70124 Bari, Italy. p.portincasa@....Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.PMID: 15609388 The full text of the article is available FREE at:http://www.wjgnet.com/1007-9327/11/7.aspUnfortunately it doesn't discuss some the medications/supplements we were discussing the other day.Best regards,Dave (father of (19); PSC 07/03; UC 08/03)

[Guest guest]

Dave & others,

Do you know if it is reported in the literature how PSC "acts" differently in males than females, or if there is any difference at all? Also, any known differences in the treatments of males vs. females?

Thanks

LINDA

(Mom of Suzanne, 15; UC 1/04; PSC 3/04)

World J Gastroenterol. 2005 Jan 7;11(1):7-16. Primary sclerosing cholangitis: Updates in diagnosis and therapy.Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van-Erpecum KJ, van-Berge-Henegouwen GP.Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males,

[Guest guest]

Dear ;

I am not aware of any studies that show that PSC progresses

differently in males versus females, or studies showing that males

and females benefit from different treatments/therapies. The risk

factors for shorter survival don't seem to be gender related, but

rather seem to be whether or not the patient has small-duct versus

large/medium-duct PSC, and whether there are other complications,

such as lower platelet count and splenomegaly. However, I have read

that being male is a risk factor for recurrence of PSC following

transplantation.

But this doesn't explain why the disease is more prevalent in males

than females. That's why I thought the study mentioned in message

number 66964 was interesting in that there is a clear gender effect

when the two nuclear receptors pregnane X receptor (PXR) and

constitutive androstane receptor (CAR) are knocked out in mice ....

males suffer from bile toxicity much more than females when these two

genes are defective.

Best regards, and I hope that Suzanne is doing well and enjoying the

holidays.

Dave

(father of (19); PSC 07/03; UC 08/03)

> Dave & others,

> Do you know if it is reported in the literature how PSC " acts "

differently in males than females, or if there is any difference at

all? Also, any known differences in the treatments of males vs.

females?

>

> Thanks

> LINDA

> (Mom of Suzanne, 15; UC 1/04; PSC 3/04)