Re: Another small duct - large duct question

[Guest guest]

Here's a quote from the Oxford PSC-support UK meeting (thanks, Ivor):

" A rare sub-group within a rare disease. PSC normally affects both

intrahepatic and extrahepatic ducts but small-duct PSC only affects the

small ducts inside the liver. Some have thought that this isn't anything

different from the usual PSC - it's only that the PSC has been discovered at

an early stage when the disease has not yet reached the large ducts. 3

studies published recently in Oxford, Scotland and the US have all produced

similar results - that there is such a thing as small-duct psc and that the

outcome is more benign than that of the usual psc. The association with UC

may also be different. 12% of those with small-duct psc will go on to

develop normal psc, in which case the outcome is similar to other pscers. "

The description you've stated sounds more like large duct to me.

Arne

53 - UC 9/77 - PSC 4/00

Alive and (mostly) well in Minnesota

-----Original Message-----

From: nichole_rowland

Before joining this group and reading these posts I never heard of small

duct verses large duct PSC.

Since my husband has not had an ERCP yet but the MRCP found:

" There was diffuse stenosis throughout the right main biliary ductal system

extendingd into the secondary branchees. Similarly, there was abnormal

stricturing withing the left main bile duct extending into the secondary

branches. There was a focal stricture of the common hapatic duct. "

Would that indicate it is large duct PSC?

[Guest guest]

Dear Nichole;

I agree with Arne that this sounds very much like large duct PSC.

A note on frequency of blood tests .... part of the reason that my

son's blood is being monitored every 3 months is that his

hepatologist wants to be sure that there are no adverse reactions to

rifampin, which he began taking in May of this year. I agree with

Barb that every 6 months would be reasonable unless new medications

[with potential for liver toxicity] were being introduced.

Best regards,

Dave

(father of (19); PSC 07/03; UC 08/03)

> " There was diffuse stenosis throughout the right main biliary

ductal system extendingd into the secondary branchees. Similarly,

there was abnormal stricturing withing the left main bile duct

extending into the secondary branches. There was a focal stricture

of the common hapatic duct. " Would that indicate it is large duct PSC?