Guest guest Posted October 13, 2004 Report Share Posted October 13, 2004 I couldn't resist posting this recent study concerning the idea that Helicobacter sp. might be responsible for a disease similar to PSC in cats: FEMS Immunol Med Microbiol. 2004 Nov 1;42(3):307-11. Detection of Helicobacter pylori in bile of cats. Boomkens SY, Kusters JG, Hoffmann G, Pot RG, Spee B, Penning LC, Egberink HF, van den Ingh TS, Rothuizen J. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80154, 3508 TD Utrecht, The Netherlands. Lymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive ( [Formula: see text] ). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir. PMID: 15477044 This study is referring to the study by Nilsson et al (2000): Nilsson HO, Taneera J, Castedal M, Glatz E, Olsson R, Wadstrom T 2000 Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis. J. Clin. Microbiol. 38: 1072-1076. PMID: 10698999. Best regards, Dave (father of (19); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2004 Report Share Posted October 14, 2004 They didn’t need to do a study - all they had to do was ask Andi! Andi said several years ago she thought H. Pylori could be a culprit. -Barb in Texas - Son Ken (30) UC 91 & PSC 99 -----Original Message----- From: recent study concerning the idea that Helicobacter sp. might be responsible for a disease similar to PSC in cats: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2004 Report Share Posted October 14, 2004 What are we talking about? My email got messed up yesterday and I didn’t receive any… Anne & Bobby RE: Cat atrophy? They didn’t need to do a study - all they had to do was ask Andi! Andi said several years ago she thought H. Pylori could be a culprit. -Barb in Texas - Son Ken (30) UC 91 & PSC 99 -----Original Message----- From: recent study concerning the idea that Helicobacter sp. might be responsible for a disease similar to PSC in cats: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2004 Report Share Posted October 14, 2004 > They didn't need to do a study - all they had to do was ask Andi! Andi > said several years ago she thought H. Pylori could be a culprit. > > -Barb in Texas - Son Ken (30) UC 91 & PSC 99 > > -----Original Message----- > From: > recent study concerning the idea that Helicobacter sp. might be > responsible for a disease similar to PSC in cats: and Barb, Yes that article is very interesting. I used to breed cats years ago, and had one particular 2 year old male Siamese that I had to have euthanized because he had Cholangiohepatitis back in 1992. There was a lot of inbreeding in his pedigree. The Siamese breed is generally very weak because of this. I also have severe GERD. Andi ***Nonsuppurative or Lymphocytic Cholangitis and Cholangiohepatitis ---------------------------------------------------------------------- ---------- Nonsuppurative, chronic, or lymphocytic cholangitis and cholangiohepatitis has a lymphocytic-plasmacytic component, suggesting an underlying immune condition. Nonsuppurative cholangitis is considered to be a chronic condition, often seen in association with chronic pancreatitis, inflammatory bowel disease, or fluke infections. Incidence may be higher in Persian cats. Clinical signs are similar to those seen with suppurative cholangiohepatitis but usually are chronic and may be steroid-responsive. Fever may not be as common as in the suppurative form. Ascites and icterus are the most common clinical signs, and lymphadenopathy may be present. If the disease has progressed to cirrhosis, then clinical signs of hepatic encephalopathy may also be seen. Laboratory abnormalities are similar to those reported for suppurative cholangiohepatitis; however, in advanced disease, hypergammaglobulinemia, hypoalbuminemia, low BUN, and coagulopathies due to vitamin K deficiency can be seen. Progression to biliary cirrhosis is possible. Supportive, antibiotic therapy and ursodeoxycholic acid can be used, with recommendations similar to those for the suppurative form of the disease. Prednisone (0.5-1 mg/lb, PO, s.i.d.) therapy is recommended in the nonsuppurative form of the disease because of the suspected immune-mediated component. Prognosis is variable. Some cats respond well to initial therapy, others relapse repeatedly, and some do not respond and succumb to the disease. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2004 Report Share Posted October 14, 2004 > > I couldn't resist posting this recent study concerning the idea that > Helicobacter sp. might be responsible for a disease similar to PSC in > cats The possible H. Pylori/PSC connection has been floating around for awhile. See this thread initiated by athan over four years ago: http://health.groups.yahoo.com/group//message/10120 - Gene A. Quote Link to comment Share on other sites More sharing options...
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