Re: Abnormal thyroid (TSH) function

[Guest guest]

, Thank you so much for this very informative information!We will definitely test for reverse T3 when we do the test again in a month.Thanks again for this.Best, TrixieSubject: Re: Abnormal thyroid (TSH) functionTo: mb12 valtrex Date: Thursday, May 27, 2010, 6:19 PM

Ooops! Forgot to copy the studies. Here they are:

Scanning Microsc. 1988 Mar;2(1):241-6.

Presence of calcium oxalate crystals in the mammalian thyroid gland.

Hackett RL, Khan SR.

Department of Pathology, College of Medicine, University of Florida, Gainesville.

Birefringent crystals of calcium oxalate have been previously identified in the

colloid of human thyroid glands. We found such crystals in 19/20 adult thyroids

at autopsy, in 4/20 infants at autopsy, and, using frozen sections, in 19/20

thyroids partially or totally removed at surgery. These crystals were soluble in

hydrochloric acid, insoluble in acetic acid, and contained only calcium by energy

dispersive X-ray microanalysis, confirming their calcium oxalate character.

Similar crystals were found in equine and ovine thyroids.

PMID: 3368759 [PubMed - indexed for MEDLINE]

Am J Clin Pathol. 1987 Apr;87(4):443-54.

Calcium oxalate crystals in the thyroid. Their identification, prevalence,

origin, and possible significance.

Reid JD, Choi CH, Oldroyd NO.

Calcium oxalate crystals are not encountered in normal animal tissues, except for

the human thyroid, where they were found in 79 of 100 routine consecutive

autopsies. They appear during childhood, and numbers of crystals increase with

age. In diffuse hyperplasia, prevalence was higher, but crystals were fewer than

expected. In adenomas and carcinomas, crystals were decreased except for three

cases with a striking focal increase. None was found in 22 adult primate

thyroids. After Clorox digestion of human thyroids, calcium oxalate dihydrate was

identified by x-ray diffraction and infrared spectroscopy. Origin, tissue and

species localization are discussed in relation to ascorbate metabolism,

thyroperoxidase, and calcitonin. Possible metabolic roles are suggested. Calcium

oxalate crystals injected in animals and humans initiate a foreign body reaction

with giant cells. In Hashimoto's thyroiditis, crystals disappear but occasionally

remain with giant cell reaction. In subacute thyroiditis, granulomas are related

more to colloid than to crystals.

PMID: 2435146 [PubMed - indexed for MEDLINE]

Virchows Arch A Pathol Anat Histopathol. 1993;422(4):301-6.

Nature and significance of calcium oxalate crystals in normal human thyroid

gland. A clinicopathological and immunohistochemical study.

Katoh R, Suzuki K, Hemmi A, Kawaoi A.

Department of Pathology, Yamanashi Medical University, Japan.

To elucidate the significance and nature of calcium oxalate crystals in the

thyroid, we studied these crystals clinicopathologically and

immunohistochemically in 182 normal thyroids from patients autopsied within 5 h

of death. Under polarized light, calcium oxalate crystals showed brilliant

birefringence and were invariably found within the colloid. The crystals were

found in 73.1% of all cases but were more prevalent and denser in older

individuals, with the highest prevalence (85.2%) being observed in those over 70

years of age. No crystals were seen in those under 10 years of age. Although

underlying diseases seemed to have little influence, post-mortem delay apparently

affected the prevalence and density of occurrence since the crystals tended to

disappear with hours after death. An immunohistochemical study using anti-thyroid

hormone antibodies revealed that the crystals were within negatively or weakly

stained colloid and were not common in strongly stained colloid. These findings

support the hypothesis that the occurrence of calcium oxalate crystals in normal

human thyroid is associated with a low functional state of the thyroid follicles.

PMID: 8506623 [PubMed - indexed for MEDLINE]

Eur J Clin Chem Clin Biochem. 1993 Sep;31(9):559-65.

Oxalate in the human thyroid gland.

Wahl R, Fuchs R, Kallee E.

Ninety-seven fixed surgical thyroid specimens and 63 unfixed and 40 fixed thyroid

specimens from autopsies were examined for their oxalate content...... The oxalate

concentrations of the samples were mainly dependent on age and gender, which were

distributed unequally among the seven diagnostic groups. In thyroid tissue from

cases of Graves' disease, however, the concentration of oxalate was remarkably

low and statistically different from those of four of the six other groups.

PMID: 8260526 [PubMed - indexed for MEDLINE]

J Pediatr. 2000 Feb;136(2):255-7.

Hypothyroidism in primary hyperoxaluria type 1.

Frishberg Y, Feinstein S, Rinat C, Drukker A.

We describe 4 patients, aged 3 months to 23 years, with end-stage renal disease

and severe, symptomatic hypothyroidism. All 4 had primary hyperoxaluria type 1

(PH1) with diffuse tissue (kidneys, skeleton, eyes, heart) calcium-oxalate

deposition, a condition known as oxalosis. The hypothyroidism responded to

thyroid hormone replacement therapy. Clinical hypothyroidism within the framework

of PH1/oxalosis was probably caused by thyroid tissue damage from an abundance of

calcium oxalate. We recommend that thyroid function be monitored in patients with

PH1 and oxalosis.

PMID: 10657836 [PubMed - indexed for MEDLINE]

Acta Cytol. 1999 Jul-Aug;43(4):575-8.

Calcium oxalate crystals in thyroid fine needle aspiration cytology.

Shimizu M, Hirokawa M, Kanahara T, Manabe T.

OBJECTIVE: To determine the occurrence, distribution and location of calcium

oxalate crystals (COCs) in thyroid fine needle cytology specimens....

RESULTS: The size and shape of COCs varied

from case to case. The total incidence was 45% (benign diseases, 68%; malignant

lesions, 21%).... CONCLUSION: The

occurrence of COCs in thyroid fine needle cytology was lower than that in

histologic specimens reported in the literature, and COCs were more often

identified in benign than malignant lesions. The presence of COCs may be a clue

to benign lesions if their distribution is taken into consideration.

PMID: 10432877 [PubMed - indexed for MEDLINE]

Am J Surg Pathol. 1993 Jul;17(7):698-705.

Birefringent (calcium oxalate) crystals in thyroid diseases. A

clinicopathological study with possible implications for differential diagnosis.

Katoh R, Kawaoi A, Muramatsu A, Hemmi A, Suzuki K.

Department of Pathology, Yamanashi Medical University, Tamaho-cho, Japan.

To elucidate the nature and significance of calcium oxalate crystals in the

pathologic thyroid, we used polarized light microscopy to review 357 thyroid

lesions. Under polarized light, calcium oxalate crystals had brilliant

birefringence, and they were invariably identified within the colloid of

follicles....

Immunohistochemistry for thyroid hormones confirmed that the crystals tended to

appear in inactive follicles. On tissue x-ray film, the crystals appeared as

microcalcifications. As a result of these findings, we suggest that examinations

of crystals are likely to be useful in the differential diagnosis of thyroid

diseases and in possible estimations of the functional state of lesions.

PMID: 8317610 [PubMed - indexed for MEDLINE]

J Comp Pathol. 1991 Jul;105(1):109-15.

Calcium oxalate in mammalian thyroids: a re-evaluation.

Reid JD.

Department of Pathology, Memorial Hospital, Ravenna, Ohio 44266.

Although calcium oxalate crystals in the thyroid have been thought to occur only

in human glands, this compound may be found in thyroid glands of a wide variety

of mammalian species. Mechanisms underlying the formation of these deposits and

their biological significance remain unclear but various possibilities are

discussed.

PMID: 1918449 [PubMed - indexed for MEDLINE]

Toxicol Appl Pharmacol. 1979 May;48(3):409-14.

The effect of dietary ingestion of oxalic acid on thyroid function in male and

female Long- rats.

Goldman M, Doering GJ.

PMID: 473187 [PubMed - indexed for MEDLINE]

> >

> > Hi everyone,

> >

> > I recently had a battery of blood tests done for my 4 year old son. He has a dx of HFA. For the past year we have been giving him MB12 shots (every other day), supernuthera, EFA/DHA, CoQ10 and a probiotic.

> >

> > His blood tests for Zink and magnisium are normal as are other minerals we tested. The only abnormal level is his TSH which is 5.4. My pediatrician (and our DAN, two seperate doctors here) both recommended testing it again in a month.

> >

> > My question is has anyone else seen this, or have any idea about it?

> >

> > Thanks in advance!

> > Trixie

> >

>

[Guest guest]

Just in case anyone is interested...our PANDAS child tested positive on the Anne

Connoly (indicating brain inflammation) and we are now testing his thyroid auto

antibodies even though a reg blood panel shows normal thyroid to rule out

Hashimoto's disease or Hashimoto's thyroiditis.

Kersten

> > >

> > > Hi everyone,

> > >

> > > I recently had a battery of blood tests done for my 4 year old son. He has

a dx of HFA. For the past year we have been giving him MB12 shots (every other

day), supernuthera, EFA/DHA, CoQ10 and a probiotic.

> > >

> > > His blood tests for Zink and magnisium are normal as are other minerals we

tested. The only abnormal level is his TSH which is 5.4. My pediatrician (and

our DAN, two seperate doctors here) both recommended testing it again in a

month.

> > >

> > > My question is has anyone else seen this, or have any idea about it?

> > >

> > > Thanks in advance!

> > > Trixie

> > >

> >

>

[Guest guest]

Kersten,Does your son have a frequent fever when not even " sick? "  I am waiting on my kids' labs but we are having them tested for PANDAS.

 

Just in case anyone is interested...our PANDAS child tested positive on the Anne Connoly (indicating brain inflammation) and we are now testing his thyroid auto antibodies even though a reg blood panel shows normal thyroid to rule out Hashimoto's disease or Hashimoto's thyroiditis.

Kersten

> > >

> > > Hi everyone,

> > >

> > > I recently had a battery of blood tests done for my 4 year old son. He has a dx of HFA. For the past year we have been giving him MB12 shots (every other day), supernuthera, EFA/DHA, CoQ10 and a probiotic.

> > >

> > > His blood tests for Zink and magnisium are normal as are other minerals we tested. The only abnormal level is his TSH which is 5.4. My pediatrician (and our DAN, two seperate doctors here) both recommended testing it again in a month.

> > >

> > > My question is has anyone else seen this, or have any idea about it?

> > >

> > > Thanks in advance!

> > > Trixie

> > >

> >

>

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.