Re: Andy-thimerosal-questions

December 11, 2002

>

> Now when these scientists prove that mercury doesn't cause

> autism, which I believe that they will be able to do, what

> happens to us (parents)?

> How do we back out of this? What do we say? Oh! wait! hold on

> a minute it wasn't thimerosal poisoning, it was that the

> thimerosal wiped out their immune defenses.

> I don't want them walking away from this. I believe they were

> responsible for not doing the science, but I don't be the 'one'

> that didn't do the science either.

> Best, Carlton

We plug away at doing what we know best for our children, and in a few years

we'll have many kids that either recovered, or made Huge improvements through

chelation. If they still won't listen

We say, then for some reason this protocol really helped my kid!!!! And while

doing it my kid dumped mercury.

>

> =======================================================

>

December 11, 2002

But...according to your view, the mercury is still causing damage, right?????

I do not understand your point.

[ ] Andy-thimerosal-questions

Andy,

I have taken a long absence from this list for research.

There were just some things about the theory that mercury causes

autism that didn't sit right with me. And I had to find out for myself

if it could be true.

My son reacted to the hepatitis B vaccination. His symptoms

appeared the day after that vaccination. And like most of the

parents here, I believe the 'vaccination' caused his autism.

However, what I couldn't believe was that the symptoms were

due to mercury poisoning. My research of thimerosal lead me

to understand how highly pathogenic anaerobic bacteria were

resistant to the effects of thimerosal. Where thimerosal could

easily wipe out gram-postive bacteria, the kind of probiotic

bacteria that serves a purpose for immune defenses, but not

that of the more harmful organisms. What I found was that

thimerosal is not your typical antibiotic or antibacterial.

It is in fact, an antimicrobial preservative and what I believe

that thimerosal has done is wipe out non-pathogenic bacteria,

leaving behind pathogenic bacteria. We know the importance of

non-pathogenic bacteria through infant studies given infant

formulas or mother's milk. I don't believe thimerosal caused

mercury poisoning, but I do believe that it did much more harm

through the destruction of the natural microflora.

Now when these scientists prove that mercury doesn't cause

autism, which I believe that they will be able to do, what

happens to us (parents)?

How do we back out of this? What do we say? Oh! wait! hold on

a minute it wasn't thimerosal poisoning, it was that the

thimerosal wiped out their immune defenses.

I don't want them walking away from this. I believe they were

responsible for not doing the science, but I don't be the 'one'

that didn't do the science either.

Best, Carlton

=======================================================

December 11, 2002

--- In , " hooten " <dhooten@a...>

wrote:

> But...according to your view, the mercury is still causing damage,

right?????

> I do not understand your point.

>

> , Let's say someone gave you something to drink, and

after that you cannot remember what happened, so you think that

person poisoned you, and you accuse them of that, But in fact,

they hit you over the head and knocked you unconscious, but

you went to the police and told them that they poisoned you.

And that is tested and it is found that you were not poisoned,

yes they are still guilty, but you just let them get away with

it because you accused them of the wrong thing. Best, Carlton

> [ ] Andy-thimerosal-questions

>

> Andy,

> I have taken a long absence from this list for research.

> There were just some things about the theory that mercury causes

> autism that didn't sit right with me. And I had to find out for

myself

> if it could be true.

> My son reacted to the hepatitis B vaccination. His symptoms

> appeared the day after that vaccination. And like most of the

> parents here, I believe the 'vaccination' caused his autism.

> However, what I couldn't believe was that the symptoms were

> due to mercury poisoning. My research of thimerosal lead me

> to understand how highly pathogenic anaerobic bacteria were

> resistant to the effects of thimerosal. Where thimerosal could

> easily wipe out gram-postive bacteria, the kind of probiotic

> bacteria that serves a purpose for immune defenses, but not

> that of the more harmful organisms. What I found was that

> thimerosal is not your typical antibiotic or antibacterial.

> It is in fact, an antimicrobial preservative and what I believe

> that thimerosal has done is wipe out non-pathogenic bacteria,

> leaving behind pathogenic bacteria. We know the importance of

> non-pathogenic bacteria through infant studies given infant

> formulas or mother's milk. I don't believe thimerosal caused

> mercury poisoning, but I do believe that it did much more harm

> through the destruction of the natural microflora.

> Now when these scientists prove that mercury doesn't cause

> autism, which I believe that they will be able to do, what

> happens to us (parents)?

> How do we back out of this? What do we say? Oh! wait! hold on

> a minute it wasn't thimerosal poisoning, it was that the

> thimerosal wiped out their immune defenses.

> I don't want them walking away from this. I believe they were

> responsible for not doing the science, but I don't be the 'one'

> that didn't do the science either.

> Best, Carlton

>

> =======================================================

>

December 11, 2002

The mercury in thimerosal poisoned these children.

Of course a lot of liars will " prove " all kinds of things because they

are paid to do so, but most people will eventually figure out that in

fact it is mercury poisoning. \

People have these silly ideas that " scientists " and " doctors " are

impartial, not like lawyers who argue diligently for whomever pays

them. I think the only real difference is that lawyers are honest

about what they are doing and the " experts " busy " impartially and

scientifically proving " this or that falsehood are not.

The whole issue of bacteria is a false lead. If the immune system

wasn't impaired the gut bacteria would go back to the correct mix in a

week or two after whatever you did to it because the gut is constantly

being re-innoculated with the correct bacteria which is found in small

quantities in and on food. Something - in this case mercury poisoning

- is preventing things from working properly.

Andy . . . . . . . . . . . .. . . .

December 11, 2002

Andy,

Interesting how you have decided to approach this discussion.

When I left this list, you were giving informed educated responses

to the effects of mercury toxicity. Yet, here all you are discussing

is liars and thieves. Did you call me a liar? I am not a liar,

and I don't get paid.

I am a mother.

The mercury poisoning is a false lead. When they injected

thimerosal preservative into control animals it caused intussusceptions

of the bowel (Blaskett et. al. J Biol Stand 1978 Oct;6(4):267-70)

It is much more difficult than you realize to re-florish bacterial

communities. Everything in our society today inhibits the production

of probiotic bacteria, so I would like to know where you think it is

coming from? We have had to ferment our milk, ferment our dough,

select only cheese that has lactic ferments, make our own pickles,

select only unbleached oats and unbleached flour, etc. It is not as easy

as you suggest. The chlorinating of water, the pasteurized milk and soy,

heat processing of food, the list goes on and on.

and I wrote a paper about it, we did our best, seeing that we are

just mothers. Someone had to put down a solid foundation. The

scientists are going to pull down mercury poisoning like a house of

cards. And I am terrified that we maybe forced to vaccinate him

again, so I wanted solid research on thimerosal.

Best, Carlton

See below

Heat-killed bacteria’s role in inducing an innate immune response and

its possible link to Autism

Carlton L Brauninger M

Introduction

Autism, a childhood disorder whose behavioral symptoms usually manifest

within the first few months of life, has been recently linked to

environmental causes. This paper presents a hypothesis that autism maybe

the result of a 'man-created disease'.

History and Today

The first known cases of autism seemed to have appeared around the

1940's in America. There were several programs of change happening

during those years: the chlorination of water, the pasteurization of

milk, and newly established immunizations to protect the health of the

public, children and adults alike. (Marr and Malloy 1996) All three of

the above mentioned programs were initiated for public safety in the

control of bacterial and viral diseases. Many new methods employed today

to eliminate or control bacterial growth include low or high

temperatures, chemicals, gases, microfiltration, bactofugation,

sanitation, and flavors. (Champagne et al 1994) Pasteurization is a

process that stops fermentation in which the medium is brought to heat

levels sufficient enough to cease the fermentation and kill the

bacteria. Vaccine programs also use this method of heat-killing

the bacteria and viruses to induce an immune response or tolerance to

the disease without infecting the patient. It is commonly known that raw

milk will sour, but pasteurized milk will putrefy. The idea that

putrefaction of the stools causes disease, i.e. intestinal

autointoxication, originated with physicians in ancient Egypt. (Chen and

Chen 1989) The toxic process, however, was reversed by the consumption

of lactic acid-producing bacteria that changed the colonic microflora

and prevented proteolysis. (Chen and Chen 1989) Autointoxication is an

ancient theory, based on the belief that intestinal waste products can

poison the body and are a major contributor to many, if not all,

diseases. (Ernst 1997)

By ancient tradition lactic acid bacteria (LAB) are involved in the

production of fermented foods. German scientists found that foods rich

in (LAB) constitute one quarter of the German diet and are characterized

by a safe history, certain beneficial health effects, and an extended

shelf life when compared with raw materials. (Hammes and Tichaczek 1994)

Microflora - 'early life studies'

In Finland, a double blind study showed that when pregnant and lactating

mothers and their babies were administered (LAB), the immunoprotective

potential of the mother's breast milk was increased. (Rautava et al

2002) The study found that the amount of anti-inflammatory transforming

growth factor beta2 (TGF-beta2) in the milk of mothers receiving (LAB)

as compared to mothers receiving a placebo was significantly higher.

(Rautava et al 2002) It documented that breast-fed babies, unlike

bottle-fed babies, have a microbic intestinal flora characterized by a

marked predominance of bifidobacteria and (LAB). (Coppa 2002) A

breast-fed, full-term baby has a preferred intestinal microbiota in

which bifidobacteria predominate over potentially harmful bacteria,

whereas, in formula-fed babies, coliforms, enterococci, and bacteroides

predominate. (Dai and 1999) It is unlikely, however, that a lower

ability to ferment carbohydrates is a major cause of increased risk of

diarrhea in formula-fed babies, but individual SCFA production may be

important. (Parrett and 1997) What happens is that the

formula-fed baby develops a much different microflora than that of a

healthy, full-term, breast-fed baby.

Autism & Ammonia- 'behavioral symptoms'

In 1989 there appears to be the first documented case of a patient with

autistic-like symptoms found to also have abnormal blood ammonia.

(Drukker 1989) Dr.Drukker's patient had symptoms of dementia, amnesia,

and cognitive disorders. (Drukker 1989) The adult was supposably

misdiagnosed as autistic. (Drukker 1989) Later in 2002, Cohen found that

by an approximate one-third reduction of GABA and ammonia levels for an

autistic patient that there was noticeable improvement of

verbal/language skills and a reduction of repetitious, ritualistic,

self-stimulatory behavior (stimming). (Cohen 2002) Lactic acid bacteria,

lactitol, and lactulose have been clinically shown to reduce blood

ammonia. (Loguercio et al 1987)(Vince and Burridge 1980) Ammonia is

produced by intestinal-bacteria. (Vince and Burridge 1980) The largest

amounts of ammonia is generated by gram-negative anaerobes, clostridia,

enterobacteria, and Bacillus spp.. (Vince and Burridge 1980)

Gram-positive non-sporing anaerobes, streptococci, and micrococci formed

modest amounts, and lactobacilli and yeasts formed very little ammonia;

and that ammonia may be formed from bacterial cells in the colon. (Vince

and Burridge 1980)

Gluten & Casein

Laboratory studies have provided evidence that casein, gliadins, and

glutenins are hydrolyzed or degraded by fermentation with (LAB),

providing better digestibility and cereal tolerance. Dietary lipids

influence the gastrointestinal microbiota and specifically, the

population of (LAB). (Bomba et al 2002) The favorable protein

utilization and body mass increment on fermented milk diets are

attributed to a better digestibility of proteins in these products.

(Vass et al 1984)(Chebbi et al 1977) Much may depend on the dough

acidification or quality of specific (LAB) species, live or heat-killed

during processing, whether bleached or unbleached flour is used,

pasteurized or raw milk in the making of consumer goods.

Several autism studies have hypothesized that the behavioral symptoms in

autism occur due to opiate-like activity. Opiates are sleep-inducing

drugs, and opioids are natural occurring peptides with similar effects.

An example would be that warm milk could induce sleep through a natural

release of peptides into the system. In autism there are characteristic

symptoms of sleeping disorders. The children were found to

have increased urinary peptides. (Whiteley and Shattock 2002) These

specific peptides were derived from dietary sources, in particular,

foods that contain gluten and casein and are known to produce

opiate-like affects. (Whiteley and Shattock 2002)

Studies preformed on the effects of beta-casomorphin-7 indicate they

activate a histamine release in vitro in the presence of copper (II).

(Lodyga-Chruscinska et al 2000) Skin tests with opioid peptides

naturally occurring in cow's milk (such as beta-casomorphin-7 and

alpha-casein) showed wheal and flare reactions similar to histamine and

codeine that were observed in all children. (Kurek et al 1995)(Kurek et

al 1992) Beta-casomorphin-7 and alpha-casein are noncytotoxic histamine

releasers in humans. (Kurek et al 1995)(Kurek et al 1992) The

bioactivities of peptides encrypted in major milk proteins are latent

until released and activated by enzymatic proteolysis, e.g. during

gastrointestinal digestion or food processing. (Meisel H, Bockelmann

1999) The proteolytic system of lactic acid bacteria can contribute to

the liberation of bioactive peptides. ((Meisel H, Bockelmann 1999)

Lactic acid bacteria were shown to liberate oligopeptides from beta- and

alpha-caseins that contain amino acid sequences present in casomorphins,

casokinines, and immunopeptides. (Meisel H, Bockelmann 1999) The further

degradation of these peptides by endopeptidases

and exopeptidases of lactic acid bacteria could lead to the liberation

of bioactive peptides in fermented milk products. (Meisel H, Bockelmann

1999)

Autism Microflora

According to recent laboratory findings some cases of late, onset

(regressive) autism may involve abnormal flora. (Finegold et al 2002)

The fecal flora of children with regressive autism showed much higher

clostridial counts than that of control children, not unlike those

studies done on breast-fed and infant formula-fed babies. (Finegold et

al 2002) The more popular among diet choices recommended for autistic

children is the casein-free and gluten-free diet. While an elimination

diet may avoid the offending proteins, it also removes all dietary

sources of lactic acid bacteria.

Elimination diets (just as in infant formulas replacing mother’s milk)

have inherent gaps that create a need for supplementation of vitamins,

minerals, and amino acids; but, it is also the absence of any lactic

acid bacteria that makes these diets problematic. In 1983, Siegenthaler

suggested that under certain conditions cultured milk, rather than fluid

milk, can be used for infant formula and child nutrition as well as for

school milk programs.(Siegenthaler 1983) Inappropriate handling of

pasteurized milk very often is responsible for a high bacterial count

and organoleptic defects.(Siegenthaler 1983) The advantages are the low

pH caused by the high lactic acid content that detrimentally affects

food spoilage and pathogenic organisms in milk. (Siegenthaler 1983)

There is a longer shelf life of the fermented product

at ambient temperatures. (Siegenthaler 1983) Fermented milk products

contain the enzyme lactase that facilitates digestion of residual

lactose even after ingestion. (Siegenthaler 1983)

Proinflammatory cytokines

Jyonouchi tested innate and adaptive immune responses in children with

developmental regression and autism spectrum disorders. (Jyonouchi et al

2001) She found that autistic children produced higher levels of

proinflammatory and counter-regulatory cytokines without stimuli than

controls. (Jyonouchi et al 2001) Her results indicate excessive innate

immune responses in a number of autistic children that may be most

evident in TNF-alpha production. (Jyonouchi et al 2001) A

fermented-milk, kefir, contains a substance that

enhances IFN-beta secretion, the active substance that was

identified to be sphingomyelin. (Osada et al 1993-94) The

gastrointestinal system is continually subjected to foreign antigenic

stimuli from food and microbes. (Schley and Field 2002) Intestinal

epithelial cells respond to lipopolysaccharides from gram-negative

bacteria. (Vidal et al 2002) Observations suggest that gram-positive

organisms from lactic acid bacteria temper this reaction and prevent an

exaggerated inflammatory response.(Vidal et al 2002)

Summary

Sixty-plus years have passed, and autism still remains a mystery.

Through the efforts made by modern technology to control bacteria and

disease the destruction of non-pathogenic bacteria has disabled our

ability to battle disease. The attempt to artificially replace mother's

milk has created a flawed and harmful bacterial ecosystem in our

offspring. Many rural societies provide a diet that contains sufficient

quantities of non-pathogenic bacteria. Dietary proteins are broken down

through a process of fermentation with non-pathogenic bacteria. A

feasible solution would be to ferment foods as has been practiced for

many centuries rather than elimination. Scientific studies have found

that the use of antibiotics were futile in the attempt to control

harmful fecal bacteria;however, non-pathogenic bacteria has been

clinically shown to be effective in studies done on other diseases with

far worse conditions. Autism is a behavioral disorder defined by

characteristic symptoms that we must better compare with other diseases

or conditions to lead us to a stronger association. Heat-killed bacteria

induce an innate immune response; however, only live bacteria can repair

mucosal barriers.

References

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P, Mudronova D.Improvement of the probiotic effect of micro-organisms

by their combination with maltodextrins, fructo-oligosaccharides and

polyunsaturated fatty acids.Br J Nutr 2002 Sep;88 Suppl 1:S95-9

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MW.Psychrotrophs in dairy products: their effects and their

control.Crit Rev Food Sci Nutr 34(1):1-301994

Chebbi NB, Chander H, Ranganathan B.Casein degradation and amino

acid liberation in milk by two highly proteolytic strains of lactic

acid bacteria.Acta Microbiol Pol 1977;26(3):281-4

Chen TS, Chen PS.Intestinal autointoxication: a medical

leitmotif.J Clin Gastroenterol 11(4):434-41,1989

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infantile autism.Med Hypotheses 2002 Jul;59(1):115

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chromatography.Dig Liver Dis 2002 Sep;34 Suppl 2:S124-8

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1;35(Suppl 1):S6-S16

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regression.J Neuroimmunol 2001 Nov 1;120(1-2):170-9

Kurek M, Przybilla B, Hermann K, Ring J.A naturally occurring

opioid peptide from cow's milk, beta-casomorphine-7, is a direct

histamine releaser in man.Int Arch Allergy Immunol 1992;97(2):115-20

Kurek M, Czerwionka-Szaflarska M, Doroszewska G.Pseudoallergic

skin reactions to opiate sequences of bovine casein in healthy

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Lodyga-Chruscinska E, Brzezinska-Blaszczyk E, Micera G, Sanna

D, Kozlowski H, Olczak J, Zabrocki J, Olejnik AK.Can the

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Mar;78(4):283-91

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Nov-Dec;15(6):335-43

Marr JS, Malloy CD. A brief history and inventory of

immunizations. J Public Health Manag Pract 2(1):82-6,1996

Meisel H, Bockelmann W.Bioactive peptides encrypted in milk

proteins: proteolytic activation and thropho-functional

properties.Antonie Van Leeuwenhoek 1999 Jul-Nov;76(1-4):207-15

Osada K, Nagira K, Teruya K, Tachibana H, Shirahata S,

Murakami H.Enhancement of interferon-beta production with

sphingomyelin from fermented milk.Biotherapy 1993-94;7(2):115-23

Parrett AM, CA.In vitro fermentation of carbohydrate

by breast fed and formula fed infants.Arch Dis Child 1997

Mar;76(3):249-53

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pregnancy and breast-feeding might confer immunomodulatory protection

against atopic disease in the infant.J Allergy Clin Immunol 2002

Jan;109(1):119-21

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fibres and prebiotics.Br J Nutr 2002 May;87 Suppl 2:S221-30

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for child nutrition.Arch Latinoam Nutr 1983 Jun;33(2):247-56

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nutritional biological characters of fermented milks.Acta Med Hung

1984;41(2-3):157-61

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bacteria.Infect Immun 2002 Apr;70(4):2057-64

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Microbiol 1980 May;13(2):177-91

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reserved.

December 11, 2002

,

I think it is awesome that your are investigating more pieces of the

puzzle..this is critical and extremely important to be doing.

Simultaneously, I hope you will be careful to not do what too many others in

science seem to be doing right now......they study one element and assume it

is the only cause. I think we have to look at the synergistic effect of

many criteria that came together and crash these kids. Your points are

extremely important and I am glad to hear that you will pursue them w/

dogged determination...but I ask you to please factor in what mercury also

does to ones gut and flora and enzymatic function and immune system and how

these would only encourage the imbalances you discuss even further. Heavy

metal toxicity plays a role somewhere because I am seeing too many children

improve once they go through detox. And my son improved tremendously from

the gfcf diet and chelation.

As an example, the ABA people often think they ARE the best therapy for

these kids....speech therapists often dont like the ABA people and criticize

their approach--ABA and speech wonder if OT is useful or a valid form of

therapy. This truthfully pisses me off because we need to address it

all--our kids need everyone to fix each part of the pie---why does everyone

want to be the ONLY way?. SAme with the biological stuff. MMR was a factor

for my son.....did it cause his autism....was it THE cause, by itself?...OF

course not!....the researchers who try to look at it like that are ignorant.

It was the mercury, the pollution in our air and food, it was that new

carpet I installed at 12 months old and then the live virus on a destroyed

gut and immune system. So did the MMR (for example)play an important

role...ABSOLUTELY. It may have not stood alone and I understand that we

must cover all our bases so that we are fully heard as I see you are

pointing out, but I hope you wont go down the same path as the others and

view your theory in isolation. Synergism is the key. Good luck to you and

thank you for being out there and doing the research!!

I would also like to point out this same problem that occurs on this

list!!!!! DMSA and ALA dont have to be the ONLY ways. We need some open

minds around here! it is okay to be cautious and careful but it is another

thing when some want to shoot down everything else and every other

way......... the ignorance then goes the other way and you have to

ask....who is being ignorant now?

[ ] Re: Andy-thimerosal-questions

> Andy,

> Interesting how you have decided to approach this discussion.

> When I left this list, you were giving informed educated responses

> to the effects of mercury toxicity. Yet, here all you are discussing

> is liars and thieves. Did you call me a liar? I am not a liar,

> and I don't get paid.

> I am a mother.

> The mercury poisoning is a false lead. When they injected

> thimerosal preservative into control animals it caused intussusceptions

> of the bowel (Blaskett et. al. J Biol Stand 1978 Oct;6(4):267-70)

> It is much more difficult than you realize to re-florish bacterial

> communities. Everything in our society today inhibits the production

> of probiotic bacteria, so I would like to know where you think it is

> coming from? We have had to ferment our milk, ferment our dough,

> select only cheese that has lactic ferments, make our own pickles,

> select only unbleached oats and unbleached flour, etc. It is not as easy

> as you suggest. The chlorinating of water, the pasteurized milk and soy,

> heat processing of food, the list goes on and on.

> and I wrote a paper about it, we did our best, seeing that we are

> just mothers. Someone had to put down a solid foundation. The

> scientists are going to pull down mercury poisoning like a house of

> cards. And I am terrified that we maybe forced to vaccinate him

> again, so I wanted solid research on thimerosal.

> Best, Carlton

> See below

> Heat-killed bacteria's role in inducing an innate immune response and

> its possible link to Autism

>

> Carlton L Brauninger M

>

> Introduction

>

> Autism, a childhood disorder whose behavioral symptoms usually manifest

> within the first few months of life, has been recently linked to

> environmental causes. This paper presents a hypothesis that autism maybe

> the result of a 'man-created disease'.

>

> History and Today

>

> The first known cases of autism seemed to have appeared around the

> 1940's in America. There were several programs of change happening

> during those years: the chlorination of water, the pasteurization of

> milk, and newly established immunizations to protect the health of the

> public, children and adults alike. (Marr and Malloy 1996) All three of

> the above mentioned programs were initiated for public safety in the

> control of bacterial and viral diseases. Many new methods employed today

> to eliminate or control bacterial growth include low or high

> temperatures, chemicals, gases, microfiltration, bactofugation,

> sanitation, and flavors. (Champagne et al 1994) Pasteurization is a

> process that stops fermentation in which the medium is brought to heat

> levels sufficient enough to cease the fermentation and kill the

> bacteria. Vaccine programs also use this method of heat-killing

> the bacteria and viruses to induce an immune response or tolerance to

> the disease without infecting the patient. It is commonly known that raw

> milk will sour, but pasteurized milk will putrefy. The idea that

> putrefaction of the stools causes disease, i.e. intestinal

> autointoxication, originated with physicians in ancient Egypt. (Chen and

> Chen 1989) The toxic process, however, was reversed by the consumption

> of lactic acid-producing bacteria that changed the colonic microflora

> and prevented proteolysis. (Chen and Chen 1989) Autointoxication is an

> ancient theory, based on the belief that intestinal waste products can

> poison the body and are a major contributor to many, if not all,

> diseases. (Ernst 1997)

> By ancient tradition lactic acid bacteria (LAB) are involved in the

> production of fermented foods. German scientists found that foods rich

> in (LAB) constitute one quarter of the German diet and are characterized

> by a safe history, certain beneficial health effects, and an extended

> shelf life when compared with raw materials. (Hammes and Tichaczek 1994)

>

> Microflora - 'early life studies'

>

> In Finland, a double blind study showed that when pregnant and lactating

> mothers and their babies were administered (LAB), the immunoprotective

> potential of the mother's breast milk was increased. (Rautava et al

> 2002) The study found that the amount of anti-inflammatory transforming

> growth factor beta2 (TGF-beta2) in the milk of mothers receiving (LAB)

> as compared to mothers receiving a placebo was significantly higher.

> (Rautava et al 2002) It documented that breast-fed babies, unlike

> bottle-fed babies, have a microbic intestinal flora characterized by a

> marked predominance of bifidobacteria and (LAB). (Coppa 2002) A

> breast-fed, full-term baby has a preferred intestinal microbiota in

> which bifidobacteria predominate over potentially harmful bacteria,

> whereas, in formula-fed babies, coliforms, enterococci, and bacteroides

> predominate. (Dai and 1999) It is unlikely, however, that a lower

> ability to ferment carbohydrates is a major cause of increased risk of

> diarrhea in formula-fed babies, but individual SCFA production may be

> important. (Parrett and 1997) What happens is that the

> formula-fed baby develops a much different microflora than that of a

> healthy, full-term, breast-fed baby.

>

> Autism & Ammonia- 'behavioral symptoms'

>

> In 1989 there appears to be the first documented case of a patient with

> autistic-like symptoms found to also have abnormal blood ammonia.

> (Drukker 1989) Dr.Drukker's patient had symptoms of dementia, amnesia,

> and cognitive disorders. (Drukker 1989) The adult was supposably

> misdiagnosed as autistic. (Drukker 1989) Later in 2002, Cohen found that

> by an approximate one-third reduction of GABA and ammonia levels for an

> autistic patient that there was noticeable improvement of

> verbal/language skills and a reduction of repetitious, ritualistic,

> self-stimulatory behavior (stimming). (Cohen 2002) Lactic acid bacteria,

> lactitol, and lactulose have been clinically shown to reduce blood

> ammonia. (Loguercio et al 1987)(Vince and Burridge 1980) Ammonia is

> produced by intestinal-bacteria. (Vince and Burridge 1980) The largest

> amounts of ammonia is generated by gram-negative anaerobes, clostridia,

> enterobacteria, and Bacillus spp.. (Vince and Burridge 1980)

> Gram-positive non-sporing anaerobes, streptococci, and micrococci formed

> modest amounts, and lactobacilli and yeasts formed very little ammonia;

> and that ammonia may be formed from bacterial cells in the colon. (Vince

> and Burridge 1980)

>

> Gluten & Casein

>

> Laboratory studies have provided evidence that casein, gliadins, and

> glutenins are hydrolyzed or degraded by fermentation with (LAB),

> providing better digestibility and cereal tolerance. Dietary lipids

> influence the gastrointestinal microbiota and specifically, the

> population of (LAB). (Bomba et al 2002) The favorable protein

> utilization and body mass increment on fermented milk diets are

> attributed to a better digestibility of proteins in these products.

> (Vass et al 1984)(Chebbi et al 1977) Much may depend on the dough

> acidification or quality of specific (LAB) species, live or heat-killed

> during processing, whether bleached or unbleached flour is used,

> pasteurized or raw milk in the making of consumer goods.

> Several autism studies have hypothesized that the behavioral symptoms in

> autism occur due to opiate-like activity. Opiates are sleep-inducing

> drugs, and opioids are natural occurring peptides with similar effects.

> An example would be that warm milk could induce sleep through a natural

> release of peptides into the system. In autism there are characteristic

> symptoms of sleeping disorders. The children were found to

> have increased urinary peptides. (Whiteley and Shattock 2002) These

> specific peptides were derived from dietary sources, in particular,

> foods that contain gluten and casein and are known to produce

> opiate-like affects. (Whiteley and Shattock 2002)

> Studies preformed on the effects of beta-casomorphin-7 indicate they

> activate a histamine release in vitro in the presence of copper (II).

> (Lodyga-Chruscinska et al 2000) Skin tests with opioid peptides

> naturally occurring in cow's milk (such as beta-casomorphin-7 and

> alpha-casein) showed wheal and flare reactions similar to histamine and

> codeine that were observed in all children. (Kurek et al 1995)(Kurek et

> al 1992) Beta-casomorphin-7 and alpha-casein are noncytotoxic histamine

> releasers in humans. (Kurek et al 1995)(Kurek et al 1992) The

> bioactivities of peptides encrypted in major milk proteins are latent

> until released and activated by enzymatic proteolysis, e.g. during

> gastrointestinal digestion or food processing. (Meisel H, Bockelmann

> 1999) The proteolytic system of lactic acid bacteria can contribute to

> the liberation of bioactive peptides. ((Meisel H, Bockelmann 1999)

> Lactic acid bacteria were shown to liberate oligopeptides from beta- and

> alpha-caseins that contain amino acid sequences present in casomorphins,

> casokinines, and immunopeptides. (Meisel H, Bockelmann 1999) The further

> degradation of these peptides by endopeptidases

> and exopeptidases of lactic acid bacteria could lead to the liberation

> of bioactive peptides in fermented milk products. (Meisel H, Bockelmann

> 1999)

>

> Autism Microflora

>

> According to recent laboratory findings some cases of late, onset

> (regressive) autism may involve abnormal flora. (Finegold et al 2002)

> The fecal flora of children with regressive autism showed much higher

> clostridial counts than that of control children, not unlike those

> studies done on breast-fed and infant formula-fed babies. (Finegold et

> al 2002) The more popular among diet choices recommended for autistic

> children is the casein-free and gluten-free diet. While an elimination

> diet may avoid the offending proteins, it also removes all dietary

> sources of lactic acid bacteria.

> Elimination diets (just as in infant formulas replacing mother's milk)

> have inherent gaps that create a need for supplementation of vitamins,

> minerals, and amino acids; but, it is also the absence of any lactic

> acid bacteria that makes these diets problematic. In 1983, Siegenthaler

> suggested that under certain conditions cultured milk, rather than fluid

> milk, can be used for infant formula and child nutrition as well as for

> school milk programs.(Siegenthaler 1983) Inappropriate handling of

> pasteurized milk very often is responsible for a high bacterial count

> and organoleptic defects.(Siegenthaler 1983) The advantages are the low

> pH caused by the high lactic acid content that detrimentally affects

> food spoilage and pathogenic organisms in milk. (Siegenthaler 1983)

> There is a longer shelf life of the fermented product

> at ambient temperatures. (Siegenthaler 1983) Fermented milk products

> contain the enzyme lactase that facilitates digestion of residual

> lactose even after ingestion. (Siegenthaler 1983)

>

> Proinflammatory cytokines

>

> Jyonouchi tested innate and adaptive immune responses in children with

> developmental regression and autism spectrum disorders. (Jyonouchi et al

> 2001) She found that autistic children produced higher levels of

> proinflammatory and counter-regulatory cytokines without stimuli than

> controls. (Jyonouchi et al 2001) Her results indicate excessive innate

> immune responses in a number of autistic children that may be most

> evident in TNF-alpha production. (Jyonouchi et al 2001) A

> fermented-milk, kefir, contains a substance that

> enhances IFN-beta secretion, the active substance that was

> identified to be sphingomyelin. (Osada et al 1993-94) The

> gastrointestinal system is continually subjected to foreign antigenic

> stimuli from food and microbes. (Schley and Field 2002) Intestinal

> epithelial cells respond to lipopolysaccharides from gram-negative

> bacteria. (Vidal et al 2002) Observations suggest that gram-positive

> organisms from lactic acid bacteria temper this reaction and prevent an

> exaggerated inflammatory response.(Vidal et al 2002)

>

> Summary

>

> Sixty-plus years have passed, and autism still remains a mystery.

> Through the efforts made by modern technology to control bacteria and

> disease the destruction of non-pathogenic bacteria has disabled our

> ability to battle disease. The attempt to artificially replace mother's

> milk has created a flawed and harmful bacterial ecosystem in our

> offspring. Many rural societies provide a diet that contains sufficient

> quantities of non-pathogenic bacteria. Dietary proteins are broken down

> through a process of fermentation with non-pathogenic bacteria. A

> feasible solution would be to ferment foods as has been practiced for

> many centuries rather than elimination. Scientific studies have found

> that the use of antibiotics were futile in the attempt to control

> harmful fecal bacteria;however, non-pathogenic bacteria has been

> clinically shown to be effective in studies done on other diseases with

> far worse conditions. Autism is a behavioral disorder defined by

> characteristic symptoms that we must better compare with other diseases

> or conditions to lead us to a stronger association. Heat-killed bacteria

> induce an innate immune response; however, only live bacteria can repair

> mucosal barriers.

>

> References

>

> Bomba A, Bomba A, Nemcova R, Gancarcikova S, Herich R, Guba

> P, Mudronova D.Improvement of the probiotic effect of micro-organisms

> by their combination with maltodextrins, fructo-oligosaccharides and

> polyunsaturated fatty acids.Br J Nutr 2002 Sep;88 Suppl 1:S95-9

>

> Champagne CP, Laing RR, Roy D, Mafu AA, Griffiths

> MW.Psychrotrophs in dairy products: their effects and their

> control.Crit Rev Food Sci Nutr 34(1):1-301994

>

> Chebbi NB, Chander H, Ranganathan B.Casein degradation and amino

> acid liberation in milk by two highly proteolytic strains of lactic

> acid bacteria.Acta Microbiol Pol 1977;26(3):281-4

>

> Chen TS, Chen PS.Intestinal autointoxication: a medical

> leitmotif.J Clin Gastroenterol 11(4):434-41,1989

>

> Cohen B.Use of a GABA-transaminase agonist for treatment of

> infantile autism.Med Hypotheses 2002 Jul;59(1):115

>

> Coppa GV, Bruni S, Zampini L, Galeazzi T, li

> O.Prebiotics in infant formulas: biochemical characterisation by thin

> layer chromatography and high performance anion exchange

> chromatography.Dig Liver Dis 2002 Sep;34 Suppl 2:S124-8

>

> Dai D, WA.Protective nutrients and bacterial

> colonization in the immature human gut.Adv Pediatr 1999;46:353-82

>

> Drukker J.Mother was right; a misdiagnosed syndromeNed Tijdschr

> Geneeskd 1989 Feb 4;133(5):195-8

>

> Ernst E.Colonic irrigation and the theory of autointoxication:

> a triumph of ignorance over science.J Clin Gastroenterol 1997

> Jun;24(4):196-8

>

> Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte

> E, McTeague M, Sandler R, Wexler H, Marlowe EM, MD, Lawson PA,

> Summanen P, Baysallar M, Tomzynski TJ, Read E, E, Rolfe R,

> Nasir P, Shah H, Haake DA, Manning P, Kaul A.Gastrointestinal

> microflora studies in late-onset autism.Clin Infect Dis 2002 Sep

> 1;35(Suppl 1):S6-S16

>

> Hammes WP, Tichaczek PS.The potential of lactic acid bacteria

> for the production of safe and wholesome food.Z Lebensm Unters Forsch

> 1994 Mar;198(3):193-201

>

> Jyonouchi H, Sun S, Le H.Proinflammatory and regulatory

> cytokine production associated with innate and adaptive immune

> responses in children with autism spectrum disorders and developmental

> regression.J Neuroimmunol 2001 Nov 1;120(1-2):170-9

>

> Kurek M, Przybilla B, Hermann K, Ring J.A naturally occurring

> opioid peptide from cow's milk, beta-casomorphine-7, is a direct

> histamine releaser in man.Int Arch Allergy Immunol 1992;97(2):115-20

>

> Kurek M, Czerwionka-Szaflarska M, Doroszewska G.Pseudoallergic

> skin reactions to opiate sequences of bovine casein in healthy

> children.Rocz Akad Med Bialymst 1995;40(3):480-5

>

> Lodyga-Chruscinska E, Brzezinska-Blaszczyk E, Micera G, Sanna

> D, Kozlowski H, Olczak J, Zabrocki J, Olejnik AK.Can the

> 1,5-disubstituted tetrazole ring modify the co-ordinating ability and

> biological activity of opiate-like peptides?J Inorg Biochem 2000

> Mar;78(4):283-91

>

> Loguercio C, Del Vecchio Blanco C, Coltorti M.Enterococcus

> lactic acid bacteria strain SF68 and lactulose in hepatic

> encephalopathy: a controlled study.J Int Med Res 1987

> Nov-Dec;15(6):335-43

>

> Marr JS, Malloy CD. A brief history and inventory of

> immunizations. J Public Health Manag Pract 2(1):82-6,1996

>

> Meisel H, Bockelmann W.Bioactive peptides encrypted in milk

> proteins: proteolytic activation and thropho-functional

> properties.Antonie Van Leeuwenhoek 1999 Jul-Nov;76(1-4):207-15

>

> Osada K, Nagira K, Teruya K, Tachibana H, Shirahata S,

> Murakami H.Enhancement of interferon-beta production with

> sphingomyelin from fermented milk.Biotherapy 1993-94;7(2):115-23

>

> Parrett AM, CA.In vitro fermentation of carbohydrate

> by breast fed and formula fed infants.Arch Dis Child 1997

> Mar;76(3):249-53

>

> Rautava S, Kalliomaki M, Isolauri E.Probiotics during

> pregnancy and breast-feeding might confer immunomodulatory protection

> against atopic disease in the infant.J Allergy Clin Immunol 2002

> Jan;109(1):119-21

>

> Schley PD, Field CJ.The immune-enhancing effects of dietary

> fibres and prebiotics.Br J Nutr 2002 May;87 Suppl 2:S221-30

>

> Siegenthaler EJ.The potential value of cultured dairy products

> for child nutrition.Arch Latinoam Nutr 1983 Jun;33(2):247-56

>

> Vass A, Szakaly S, Schmidt P.Experimental study of the

> nutritional biological characters of fermented milks.Acta Med Hung

> 1984;41(2-3):157-61

>

> Vidal K, Donnet- A, Granato D.Lipoteichoic acids from

> Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus

> strain La10 antagonize the responsiveness of human intestinal

> epithelial HT29 cells to lipopolysaccharide and gram-negative

> bacteria.Infect Immun 2002 Apr;70(4):2057-64

>

> Vince AJ, Burridge SM.Ammonia production by intestinal

> bacteria: the effects of lactose, lactulose and glucose.J Med

> Microbiol 1980 May;13(2):177-91

>

> Whiteley P, Shattock P.Biochemical aspects in autism spectrum

> disorders: updating the opioid-excess theory and presenting new

> opportunities for biomedical intervention.Expert Opin Ther Targets

> 2002 Apr;6(2):175-83

>

> reserved.

>

> =======================================================

>

December 11, 2002

> My son reacted to the hepatitis B vaccination. His symptoms

> > appeared the day after that vaccination. And like most of the

> > parents here, I believe the 'vaccination' caused his autism.

> > However, what I couldn't believe was that the symptoms were

> > due to mercury poisoning. My research of thimerosal lead me

> > to understand how highly pathogenic anaerobic bacteria were

> > resistant to the effects of thimerosal. Where thimerosal could

> > easily wipe out gram-postive bacteria, the kind of probiotic

> > bacteria that serves a purpose for immune defenses, but not

> > that of the more harmful organisms. What I found was that

> > thimerosal is not your typical antibiotic or antibacterial.

> > It is in fact, an antimicrobial preservative and what I believe

> > that thimerosal has done is wipe out non-pathogenic bacteria,

> > leaving behind pathogenic bacteria. We know the importance of

> > non-pathogenic bacteria through infant studies given infant

> > formulas or mother's milk. I don't believe thimerosal caused

> > mercury poisoning, but I do believe that it did much more harm

> > through the destruction of the natural microflora.

> > Now when these scientists prove that mercury doesn't cause

> > autism, which I believe that they will be able to do, what

> > happens to us (parents)?

I don't think anyone can prove mercury " caused " it but will find

evidence that it was certainly a contributing if not main instigating

factor.

> > How do we back out of this? What do we say? Oh! wait! hold on

> > a minute it wasn't thimerosal poisoning, it was that the

> > thimerosal wiped out their immune defenses.

> > I don't want them walking away from this. I believe they were

> > responsible for not doing the science, but I don't be the 'one'

> > that didn't do the science either.

> > Best, Carlton

Couldnt poisioning and destruction of microflora be occuring together?

Im not sure I completely follow what you are getting at either.

If I understand you correctly ,

If thimerasol didnt poison these kids and the only effect it has in

autism has been to inhibit non-pathogenic bacteria -> triggering a

negative immune response - how then would you explain brain lesions

consistent with mercury exposures from with the research from Canada

and Baskin, in autistics (and alzhiemer patients)?

I was pretty shocked that Dr Baskin had done research on human brain

tissue. I would recommend that you look at his research.

Our son's reactions to the vaccinations where consistent with the

symptoms of mercury poisioning. Does non-pathenogenic bacteria die-

off or pathenogenic bacterial growth mirror that?

I know this. Shortly after it was injected in, it fried his brain

growth that was occuring at that time in his development. It's as if

those functions that were making such rapid devleopment at that point

were frozen to that point in time - most notably speech and fine

motor skills in my son's case.

(Has anyone else, who observed sudden reactions like we did, observe

this " stuck in that development phase " phenonuem?)

In those same hours it did it's work on his non-pathenogenic bacteria

too Im sure. God only knows what else it could have done or may still

be doing - Ive certainly read enough on this list and others to fill

my head for the rest of my life of what other things happen from

mercury exposures.

Im sure the continuing insult to the gut limits his further brain

development from proper nutrtion and/or toxic effects from

pathenogenic bacteria. But the initial whack from the heavy bolus

dose of mercury certainly poisoned our son and destroyed brain cells

without the help from pathenogenic bacterial effects in the first few

hours.

I do hope you have found an angle with the pasteurization/proccessing

of foods angle that helps over come this all. It certainly would be a

better way then adding yet another drug and all these supplements to

help solve the problem and help the body heal itself.

Please keep me updated.

December 11, 2002

> Andy,

> Interesting how you have decided to approach this discussion.

> When I left this list, you were giving informed educated responses

> to the effects of mercury toxicity. Yet, here all you are discussing

> is liars and thieves. Did you call me a liar?

No.

>I am not a liar,

> and I don't get paid.

> I am a mother.

> The mercury poisoning is a false lead.

It is correct.

>When they injected

> thimerosal preservative into control animals it caused

intussusceptions

> of the bowel (Blaskett et. al. J Biol Stand 1978 Oct;6(4):267-70)

> It is much more difficult than you realize to re-florish bacterial

> communities. Everything in our society today inhibits the production

> of probiotic bacteria, so I would like to know where you think it is

> coming from? We have had to ferment our milk, ferment our dough,

> select only cheese that has lactic ferments, make our own pickles,

> select only unbleached oats and unbleached flour, etc. It is not as

easy

> as you suggest.

Sure it is. If you don't have mercury poisoning. If you do, then it

is hard.

>The chlorinating of water, the pasteurized milk and soy,

> heat processing of food, the list goes on and on.

> and I wrote a paper about it, we did our best, seeing that we

are

> just mothers. Someone had to put down a solid foundation. The

> scientists are going to pull down mercury poisoning like a house of

> cards. And I am terrified that we maybe forced to vaccinate him

> again, so I wanted solid research on thimerosal.

> Best, Carlton

> See below

> Heat-killed bacteria's role in inducing an innate immune response

and

> its possible link to Autism

>

> Carlton L Brauninger M

>

> Introduction

>

> Autism, a childhood disorder whose behavioral symptoms usually

manifest

> within the first few months of life, has been recently linked to

> environmental causes. This paper presents a hypothesis that autism

maybe

> the result of a 'man-created disease'.

>

> History and Today

>

> The first known cases of autism seemed to have appeared around the

> 1940's in America. There were several programs of change happening

> during those years: the chlorination of water, the pasteurization of

> milk, and newly established immunizations to protect the health of

the

> public, children and adults alike. (Marr and Malloy 1996) All three

of

> the above mentioned programs were initiated for public safety in the

> control of bacterial and viral diseases. Many new methods employed

today

> to eliminate or control bacterial growth include low or high

> temperatures, chemicals, gases, microfiltration, bactofugation,

> sanitation, and flavors. (Champagne et al 1994) Pasteurization is a

> process that stops fermentation in which the medium is brought to

heat

> levels sufficient enough to cease the fermentation and kill the

> bacteria. Vaccine programs also use this method of heat-killing

> the bacteria and viruses to induce an immune response or tolerance

to

> the disease without infecting the patient. It is commonly known that

raw

> milk will sour, but pasteurized milk will putrefy. The idea that

> putrefaction of the stools causes disease, i.e. intestinal

> autointoxication, originated with physicians in ancient Egypt. (Chen

and

> Chen 1989) The toxic process, however, was reversed by the

consumption

> of lactic acid-producing bacteria that changed the colonic

microflora

> and prevented proteolysis. (Chen and Chen 1989) Autointoxication is

an

> ancient theory, based on the belief that intestinal waste products

can

> poison the body and are a major contributor to many, if not all,

> diseases. (Ernst 1997)

> By ancient tradition lactic acid bacteria (LAB) are involved in the

> production of fermented foods. German scientists found that foods

rich

> in (LAB) constitute one quarter of the German diet and are

characterized

> by a safe history, certain beneficial health effects, and an

extended

> shelf life when compared with raw materials. (Hammes and Tichaczek

1994)

>

> Microflora - 'early life studies'

>

> In Finland, a double blind study showed that when pregnant and

lactating

> mothers and their babies were administered (LAB), the

immunoprotective

> potential of the mother's breast milk was increased. (Rautava et al

> 2002) The study found that the amount of anti-inflammatory

transforming

> growth factor beta2 (TGF-beta2) in the milk of mothers receiving

(LAB)

> as compared to mothers receiving a placebo was significantly higher.

> (Rautava et al 2002) It documented that breast-fed babies, unlike

> bottle-fed babies, have a microbic intestinal flora characterized by

a

> marked predominance of bifidobacteria and (LAB). (Coppa 2002) A

> breast-fed, full-term baby has a preferred intestinal microbiota in

> which bifidobacteria predominate over potentially harmful bacteria,

> whereas, in formula-fed babies, coliforms, enterococci, and

bacteroides

> predominate. (Dai and 1999) It is unlikely, however, that a

lower

> ability to ferment carbohydrates is a major cause of increased risk

of

> diarrhea in formula-fed babies, but individual SCFA production may

be

> important. (Parrett and 1997) What happens is that the

> formula-fed baby develops a much different microflora than that of a

> healthy, full-term, breast-fed baby.

>

> Autism & Ammonia- 'behavioral symptoms'

>

> In 1989 there appears to be the first documented case of a patient

with

> autistic-like symptoms found to also have abnormal blood ammonia.

> (Drukker 1989) Dr.Drukker's patient had symptoms of dementia,

amnesia,

> and cognitive disorders. (Drukker 1989) The adult was supposably

> misdiagnosed as autistic. (Drukker 1989) Later in 2002, Cohen found

that

> by an approximate one-third reduction of GABA and ammonia levels for

an

> autistic patient that there was noticeable improvement of

> verbal/language skills and a reduction of repetitious, ritualistic,

> self-stimulatory behavior (stimming). (Cohen 2002) Lactic acid

bacteria,

> lactitol, and lactulose have been clinically shown to reduce blood

> ammonia. (Loguercio et al 1987)(Vince and Burridge 1980) Ammonia is

> produced by intestinal-bacteria. (Vince and Burridge 1980) The

largest

> amounts of ammonia is generated by gram-negative anaerobes,

clostridia,

> enterobacteria, and Bacillus spp.. (Vince and Burridge 1980)

> Gram-positive non-sporing anaerobes, streptococci, and micrococci

formed

> modest amounts, and lactobacilli and yeasts formed very little

ammonia;

> and that ammonia may be formed from bacterial cells in the colon.

(Vince