MB12 and Cobalt

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http://www.ageofautism.com/2010/05/critical-response-to-study-of-mb12-injections\

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From Dr. Mc Candless.A study just came out about the methylcobalamin form of Vit B12, concerning possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:That this article and content was to be published was nothing new to me because it first came to my attention when the Geirs presented their theory at Cherry Hill a year ago. I lecture to physicians about the flaws in this study when doing training seminars. A full discussion would take an hour or more to write so I will only list a few key points here. It is the cobalt inorganic salts that are toxic, not the organic form of cobalt that is bound on all four binding sites in the corrin ring. The more we take of B12 by any route of administration, the more that passes unchanged from the blood to the urine. If one did not find it to be high in the urine, then that would indicate a problem. Laboratories do not differentiate between organic and inorganic amounts of cobalt but report the total amount of cobalt present along with a reference range that was created for the inorganic toxic form for miners and "old fashioned beers" (no longer used). Ananalogy would be to consider the total number of eggs one will be adding to a cake mix before and after it is baked and then try to compare the taste and texture of eggs to a cake. As an environmental physician, we see fairly rapid cause and effect for truly toxic agents, only one of which are heavy metals or metals in general. The effects of mercury or lead or arsenic are just as rapid and severe after exposure as are the effects from toxic amounts of poisonous chemicals. Therefore, common sense dictates that from the thousands of children I have treated, added to that the tens of thousands of children who have now been treated worldwide, if there really was a problem we would have seen it by now and that the effects would be pronounced. Exactly the opposite is what we as clinicians and parents see to be the case. Add to that incredible amount of clinical data that has and continues to be accumulated the fact that other published "clinical"studies (not quoted in the Geir article) support the fact that higher doses are safe and possibly more effective than lower doses. All of that should be taken into account and weighed against the findings of the recent 2010 Okada rat study. In that study whereby rat's nerves were transected, they found that the methyl analog of the B12 family was significantly more biologically active than any other form of B12. They also documented that it is the shortest lived analog and therefore clinicians should consider giving it by injections instead of the usual routes of administration. In addition, they found the greatest benefits at high to very high doses. What occurred in the rat's nervous tissue under these conditions (organic cobalt plus the cobalamin molecule) was that it increased the length of axons, increased formation of neurites, increased resistance to apoptosis, was involved in kinase signaling pathways, and helped repair the transectednerves. Therefore, what you do with "this study" is up to you but "published studies show" that mercury and vaccines are safe and not related to the autism epidemic. Many other "published studies" have proven many things we believe to not be true but are passed along as fact. Therefore, the final thing that any parent has to do, you just being one of them, is to decide for yourself what you choose to believe and after that follow your heart. I have no qualms with that. However, as for me, after observing thousands of my own patients do so well on injectable MB12, and where the majority of them do even better with daily shots than every two or three day shots, I can confidently say I've read the study and do not agree with its implications or conclusions other than the statement that is "politically correct" to state in all publications -- "we need more studies!" I agree. However, we also need more kids being able to partake of a powerfultreatment as one major tool on their road to recovery. With that I cast my vote with MB12.Sincerely, Jim Neubrander, M.Dps I'm voting with Jim Neubrander. Dr. JM

MB12 and Cobalt

http://www.ageofautism.com/2010/05/critical-response-to-study-of-mb12-injections.html

[Guest guest]

From Dr. Mc Candless.A study just came out about the methylcobalamin form of Vit B12, concerning possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:That this article and content was to be published was nothing new to me because it first came to my attention when the Geirs presented their theory at Cherry Hill a year ago. I lecture to physicians about the flaws in this study when doing training seminars. A full discussion would take an hour or more to write so I will only list a few key points here. It is the cobalt inorganic salts that are toxic, not the organic form of cobalt that is bound on all four binding sites in the corrin ring. The more we take of B12 by any route of administration, the more that passes unchanged from the blood to the urine. If one did not find it to be high in the urine, then that would indicate a problem. Laboratories do not differentiate between organic and inorganic amounts of cobalt but report the total amount of cobalt present along with a reference range that was created for the inorganic toxic form for miners and "old fashioned beers" (no longer used). Ananalogy would be to consider the total number of eggs one will be adding to a cake mix before and after it is baked and then try to compare the taste and texture of eggs to a cake. As an environmental physician, we see fairly rapid cause and effect for truly toxic agents, only one of which are heavy metals or metals in general. The effects of mercury or lead or arsenic are just as rapid and severe after exposure as are the effects from toxic amounts of poisonous chemicals. Therefore, common sense dictates that from the thousands of children I have treated, added to that the tens of thousands of children who have now been treated worldwide, if there really was a problem we would have seen it by now and that the effects would be pronounced. Exactly the opposite is what we as clinicians and parents see to be the case. Add to that incredible amount of clinical data that has and continues to be accumulated the fact that other published "clinical"studies (not quoted in the Geir article) support the fact that higher doses are safe and possibly more effective than lower doses. All of that should be taken into account and weighed against the findings of the recent 2010 Okada rat study. In that study whereby rat's nerves were transected, they found that the methyl analog of the B12 family was significantly more biologically active than any other form of B12. They also documented that it is the shortest lived analog and therefore clinicians should consider giving it by injections instead of the usual routes of administration. In addition, they found the greatest benefits at high to very high doses. What occurred in the rat's nervous tissue under these conditions (organic cobalt plus the cobalamin molecule) was that it increased the length of axons, increased formation of neurites, increased resistance to apoptosis, was involved in kinase signaling pathways, and helped repair the transectednerves. Therefore, what you do with "this study" is up to you but "published studies show" that mercury and vaccines are safe and not related to the autism epidemic. Many other "published studies" have proven many things we believe to not be true but are passed along as fact. Therefore, the final thing that any parent has to do, you just being one of them, is to decide for yourself what you choose to believe and after that follow your heart. I have no qualms with that. However, as for me, after observing thousands of my own patients do so well on injectable MB12, and where the majority of them do even better with daily shots than every two or three day shots, I can confidently say I've read the study and do not agree with its implications or conclusions other than the statement that is "politically correct" to state in all publications -- "we need more studies!" I agree. However, we also need more kids being able to partake of a powerfultreatment as one major tool on their road to recovery. With that I cast my vote with MB12.Sincerely, Jim Neubrander, M.Dps I'm voting with Jim Neubrander. Dr. JM

MB12 and Cobalt

http://www.ageofautism.com/2010/05/critical-response-to-study-of-mb12-injections.html