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RE: Synthetic Blood

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It was sorta kind of invented here in Texas. Dr. Pepe is in on the studies

BIG time.

Lots of promise.

Louis N. Molino, Sr., CET

FF/NREMT-B/FSI/EMSI

LNMolino@...

(Home Office)

(NERRTC Office)

" A Texan with a Jersey Attitude "

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At 09:03 AM 3/17/2004, you wrote:

>I hear that Denver is testing the use of synthetic blood for the

>replacement fluid of choice. Have any of yall ever heard of this

>elsewhere? Texas by chance?

Polyheme is a multicenter prehospital trial and involves about 25

agencies/cities currently.

Jim<

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Herman Life Flight out of Houston

Sundseth

EMS Director

City of Pearland

- Fax

" txnremt "

<txnremt@yahoo To:

.com> cc:

Subject: Synthetic

Blood

03/17/2004

10:03 AM

Please respond

to

I hear that Denver is testing the use of synthetic blood for the

replacement fluid of choice. Have any of yall ever heard of this

elsewhere? Texas by chance?

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There are two products undergoing clinical testing. Neither is synthetic per

se, one is a human blood derivative and the other a bovine blood derivative.

They are called hemoglobin-based oxygen-carrying solutions (HBOCs)

Hemoglobin-based oxygen-carrying solutions (HBOCs) represent a major

development in the field of emergency and critical care. These products

differ from other intravenous fluids in that they have the capability to

transport oxygen. HBOCs contain long-chains of polymerized hemoglobin. This

hemoglobin is obtained from either expired donated human blood or bovine

(cow) blood. The hemoglobin is removed from the red blood cells and then

repeatedly filtered to remove any infectious substances of antigenic

proteins. Finally, the individual hemoglobin molecules are joined together

in a large chain through a chemical process known as polymerization. HCOCs

are compatible with all blood types and do not require blood typing, testing

or cross-matching.

.. PolyHeme is a HBOCs derived from expired donated human blood.

PolyHeme contains 50 grams of hemoglobin per unit which is the same as human

blood. PolyHeme must be refrigerated and the shelf-life is 1 year. This is

the product in the multi-center EMS study.

.. Hemopure is a HBOCs derived from bovine (cow) blood. It has been

widely used in South Africa. Hemopure does not require room temperature and

has a shelf life of 3 years. This is the stuff the Army is backing and Pepe

is involved in in Dallas.

Just to clear things up.

Bledsoe, DO, FACEP

Midlothian, TX

Be good and you will be lonesome.

-Mark Twain (from " Following the Equator " )

Don't miss EMStock 2004!

http://www.emstock.com

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