Guest guest Posted April 1, 2010 Report Share Posted April 1, 2010 The Vanecko family is gone from March 27 to April 1 so they will not be able to respond until April 2. -The Vaneckos On Mar 28, 2010, at 9:02 PM, mb12 valtrex wrote: > Nasal Spray MB12, Antivirals, Stan Kurtz > Messages In This Digest (25 Messages) > 1.1. > Re: for those with recovered kids or nearly recovered... From: > chatting_cells > 1.2. > Re: for those with recovered kids or nearly recovered... From: > 2a. > Re: Teeth Grinding? From: kcboone > 2b. > Re: Teeth Grinding? From: SHARON SMITH > 2c. > Re: Teeth Grinding? From: dbklein34@... > 2d. > Re: Teeth Grinding? From: nancy cook > 2e. > Re: Teeth Grinding? From: dbklein34@... > 2f. > Re: Teeth Grinding? From: nancy cook > 2g. > Re: Teeth Grinding? From: dbklein34@... > 2h. > Re: Teeth Grinding? From: nancy cook > 3.1. > Re: Dr. Moulden From: Sloan > 4. > How much Brainchild OLE to give ? From: Jo > 5. > A question for Goddin From: Oriana > 6a. > Re: B12 test high From: Dennis and Beth > 7a. > Re: Gut Pain Cause? From: > 8a. > Re: question about newborn acne From: Cheryl Lowrance > 9a. > Re: question about growth and dietary issues From: Cheryl Lowrance > 10. > Molecular Diseases From: a DeVelbiss > 11. > Vaccination Is A Rights Issue! From: a DeVelbiss > 12. > Nephritis From: keda > 13a. > PANDAS AND Clostridia From: > 13b. > Re: PANDAS AND Clostridia From: Virginia > 14a. > question about probiotics From: > 14b. > Re: question about probiotics From: vel_villalobos@... > 14c. > Re: question about probiotics From: vel_villalobos@... > View All Topics | Create New Topic > Messages > 1.1. > Re: for those with recovered kids or nearly recovered... > Posted by: " chatting_cells " chatting_cells@...  > chatting_cells > Sun Mar 28, 2010 1:57 am (PDT) > > > Hi , > > I'm very happy for you after reading your post about what you did > for your son and your brother.....they are so blessed to have you in > their lives :-) > > Parden my ignorance...could you tell me what OoO is ? > > Thanks ! > > > > > Do all kids who have yeast, parasites, viral infiltration have a > hard time gaining weight or growing? I am just curious because my > daughter shows signs of the yeast issues as described by many of you > all, but she's not had a problem gaining weight since she was one > years old... she has always been like 75% for height, 50% for weight > (once we got over that initial weight gain issue when she was a tiny > baby) > > > > -- > > Toni > > > > ------ > > Mind like a steel trap... > > Rusty and illegal in 37 states. > > > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (2) > 10. > Molecular Diseases > Posted by: " a DeVelbiss " gabrieladevelbiss@...  > gabrieladevelbiss > Sun Mar 28, 2010 2:49 pm (PDT) > > >  > > Molecular Diseases >  >   > > STAR SCIENCE By A. Padlan, PhD and Gisela P. Padilla-Concep... > >  (The Philippine Star) Updated March 04, 2010 > > Sixty years ago, Linus ing, in a landmark paper published in > Science with several colleagues, proposed the concept of molecular > disease. The idea that a disease may be caused by a defect in a > molecule was a departure from common belief at that time. ing > specifically focused on sickle-cell anemia, in which red blood cells > became deformed from the normal disk-shape to a sickle-like shape > (thus the name) and became stiff (no longer pliable) so that they > could no longer easily squeeze through narrow blood vessels > (capillaries and venules). The resulting blockages caused > inflammations, severe pain, infections, organ damage, and early > death. ing proposed that the disease was caused by a defect in > the hemoglobin molecule. >  > Experiments showed that sickle-cell hemoglobin, under the influence > of an electric field, moved at a speed different from normal > hemoglobin, indicating that indeed there was a difference between > the two. Subsequent sequence analysis then showed that the beta > chain of sickle-cell hemoglobin differs from the beta chain of > normal hemoglobin at position 6, where sickle-cell hemoglobin has > the amino acid valine, while normal hemoglobin has glutamic acid. > (The hemoglobin in red blood cells is made up of four chains > identical in pairs: two alpha chains and two beta chains.) There > were no other differences. >  > It was also observed that sickle-cell hemoglobin formed long bundles > of fibers, or rods — but only when the molecule is deoxygenated. > (The hemoglobin in blood binds oxygen reversibly and functions as an > oxygen transporter. It picks up oxygen from the lungs > > (becomes oxygenated) and delivers the oxygen to the tissues (becomes > deoxygenated) .) It is those rods which cause the deformation and > stiffening of the red blood cells. Three-dimensional structure > analysis of deoxygenated sickle-cell hemoglobin by Warner Love's > group at s Hopkins revealed that the valine at position 6 > fortuitously fits in a hydrophobic pocket of a nearby molecule and > this (unfortunate) situation caused the formation of the rods. The > glutamic acid in normal hemoglobin, being charged, would not bind in > the pocket. Further, the binding could occur only when the > molecule is deoxygenated. (The hemoglobin molecule changes shape > when going from the oxygenated to the deoxygenated state.) Sickle- > cell anemia was clearly a molecular disease. >  > > Since then, many more diseases have been found to have a molecular > cause and a molecular disease became known as one in which the > pathogenesis (how the disease comes about and manifests itself) can > be traced to a single critical molecule, usually a protein. The > protein is either produced defectively (like hemoglobin in sickle- > cell anemia), not produced at all, or produced in abnormal (reduced > or elevated) amounts. There is a disease called alpha Thalassemia > major which affects mostly Southeast Asians, Chinese and Filipinos. > It is severe and results in death before or soon after birth. It is > caused by the complete absence of the gene that produces the alpha > chain of hemoglobin. > The ultimate cause of molecular disease is genetic — faulty > genes, and the fault could be simply a single nucleotide variation > from the normal. The fault could be a mutation in the gene that > codes for the particular protein, as in sickle-cell anemia, or it > could be the complete absence of the gene itself, as in alpha > Thalassemia major. The fault could be in the gene that controls the > expression of a particular protein, or in the gene for a protein > that modulates the activity of that protein. The defect could be in > only one copy of a gene (we inherit two copies — one from our > mother, one from our father), or in both copies. Or the disease > could be caused by an unusual number (e.g., duplication) of a > particular gene, or chromosome. Defects in the genes that control a > protein's expression or activity result in abnormal amounts of the > active protein. >  > For example, a type of severe combined immunodeficiency (SCID) has > been found to be caused by a defective enzyme, adenosine > deaminase. The result of this defect is the inadequate production > of lymphocytes that are crucial elements in our immune system. Thus, > individuals suffering from SCID are unable to fight infections and > have to live in sterile environments, e.g. bubbles, to remain alive. >  > Another example is Hunter syndrome, which results from the absence > or inadequate production of a crucial enzyme, iduronate-2- > sulfatase. The gene responsible for the disease is found in the X > chromosome. Females, who have two copies of the X chromosome, will > not be affected if the defect occurs in only one of the chromosomes. > Males, who have only one copy of the X chromosome, are not so lucky. >  > In our country, geneticists at the Institute of Human Genetics in UP > Manila are studying the occurrence of Thalassemias and sickle-cell > anemia in the Philippine population. Also at UP Manila, a newborn > (babies) screening center to test for treatable genetic diseases has > been operating for many years. There are tests for endocrinologic > (hormone-related) and metabolic (carbohydrate and amino acid) > disorders or inborn errors. By the Newborn Screening Program Act of > 2004 (Republic Act 9288), this service has been available to a > network of hospitals, lying-ins, and Rural Health Units and Health > Centers (RHUHCs) nationwide with cooperation from the DOH. >  > How can testing newborns help? Take for example, phenylketonuria > (PKU), an inborn error of amino acid metabolism. If a baby has a > genetic disorder that leads to low levels of phenyl hydroxylase, the > enzyme that converts the amino acid phenylalanine to the amino acid > tyrosine, a diet low in phenylalanine and high in tyrosine will > solve the problem. If the diet is not adjusted early, phenylalanine > from a normal diet accumulates and is converted to phenyl pyruvate > (a phenyl ketone, thus the name phenylketonuria) , which causes > problems with brain development, and leads to progressive mental > retardation and seizures. >  > Are cancer, diabetes, and cardiovascular disease (CVD) molecular > diseases? Yes, they are too, in a fundamental and general sense. But > they involve defects in more than one critical molecule. Cancer is > considered a polygenic disease (with mutations occurring > progressively in many genes and proteins); increased risk for > diabetes type 2 and CVD is associated with " metabolic > syndrome " (with defects involving several interrelated metabolic > pathways), and all three are considered complex diseases [complex, > meaning with many defects, as opposed to one defect (the original or > strict definition of a molecular disease)]. > Are molecular diseases always inherited from the genes of either one > of our parents? Based on the new wider definition of molecular > diseases — no, some mutations can be acquired in one's lifetime. > We live in an environment that can cause mutations to our genes > through the air and sunlight, our food and drink, and through > certain stressful physiologic conditions in our body. Some mutations > are inherited, while some are sporadically acquired. >  > In some cases, the genetic defect does not immediately cause > disease, but leads to the propensity for disease. An example is the > susceptibility to cancer that has been traced to a defect in p53, a > tumor suppressor protein. (p53 binds to DNA and this results in the > production of a protein that is involved in the suppression of cell > growth. A mutation in p53, that causes it to no longer bind DNA > effectively, results in uncontrolled cell growth and to tumor > formation.) Mutation s in other tumor suppressor genes, like the > BRCA1 (breast cancer 1) and BRCA2 genes, have been correlated with > higher incidence of cancer. Is the mutation found in a tumor mass > inherited or sporadic? One can easily find out. If the mutation is > found only in the tumor cells and not in the person's normal cells, > it is a sporadic one. >  > Even some personality disorders appear to have a genetic cause. For > example, there is a recent report that the tendency toward pair- > bonding, or monogamy, seems to be associated with the number of > copies of a particular gene variant (allele) that a person has. > Surprisingly (maybe not), the association is found only in males. > Men with two copies of the allele are more likely not to form long- > term bonds with their partners. > In reality, all diseases are molecular. Effective treatments > > require molecular medicine, and disease prevention and diagnosis > require molecular analysis. Nowadays, medical doctors and biomedical > scientists are focused on the understanding of the molecular basis > of diseases. It all goes back to Linus ing, that most intuitive, > quintessential molecular scientist, one of the greatest scientific > minds of our time, who first pointed out molecular diseases. He also > said that " man is simply a collection of molecules " and " can be > understood in terms of molecules. " >  > > * * * > A. Padlan is a corresponding member of the NAST and is an > adjunct professor in the UP Marine Science Institute. He can be > reached at epadlanupmsi (DOT) ph. >  > Gisela P. Padilla-Concepcion is a member of the NAST and is a > professor in the UP Marine Science Institute and chairs the Dean's > Office on Special Initiatives for the Advancement of the Sciences, > College of Science, UP Diliman. She can be reached at gpconcepcion@ > gmail.com. > > Love, Gabby. :0) > http://stemcellforautism.blogspot.com/ > http://www.facebook.com/gabby911 > http://twitter.com/stemcell4autism > >  > " I know of nobody who is purely Autistic or purely neurotypical. > Even God had some Autistic moments, which is why the planets all > spin. " ~ Jerry Newport  > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 11. > Vaccination Is A Rights Issue! > Posted by: " a DeVelbiss " gabrieladevelbiss@...  > gabrieladevelbiss > Sun Mar 28, 2010 3:13 pm (PDT) > > > > > If you're new to the list and wondering what this is all about, > please take a moment to read before erasing the note. We are > organizing a big national rally in Grant Park, downtown Chicago, on > May 26, 2010. > > And the reason is simple. > > Americans are very concerned about increased government compulsion > to vaccinate as a requirement for daycare, school and employment. > > Here's what you need to understand. > > You're being asked to fight the old war! And the argument is fear- > based... if you stop vaccinating, deadly diseases will return. We're > told, just get your damn vaccines. > > Government has no answers about fighting today's war. America has > the infant and maternal mortality rates of a Third World country. We > rank 45th in life expectancy. Our children: 10% with asthma, 4% food > allergies, 3-5% birth defects, 1% autism. Look around and what do > you see? ADD, peanut anaphylaxis, diabetes, eczema, seizures, OCD, > speech delays. Adults are no better off, chronically ill, fed a > steady diet of prescription meds. Half of all men, one-third of > women today will get cancer in their lifetime. > > Vaccine risks are known and documented. Some are killed or injured > by vaccines. Pick a shot and take a peek: package inserts and VAERS. > > There is no informed consent for vaccines. > > Vaccine makers have exceptionally strong liability protections. We > have removed their incentive to make safer shots. We have increased > their incentive to make more shots. And they have. > > If you're injured, you're on your own. Check out what the PREP Act > did for H1N1 swine flu vaccine manufacturers. > > Whether you start with the U.S. Constitution, the Universal > Declaration of Human Rights, or customary international law, people > understand what it means to be free. It means we have the right to > make the important decisions that affect our lives and those of our > children. This includes where we worship and the autonomy to control > and safeguard our own bodies. > > Vaccination is a rights issue. > > REGISTER!!! > > Two months and counting! > > If you are going to the rally, we need you to register right now. > Please!! Click this link or go to the rally website and sign up. > > Rest assured that we will not give your name to anyone else, for any > reason. > > And it is very easy to remove yourself from the list. If you are > getting this action alert now, you are already on our big list. By > registering, you will go into the Rally " bucket " so we can count you > for planning purposes. > > If you change your mind and no longer want to be on the big list, it > is very easy. Just scroll down to the bottom of this newsletter, > click Unsubscribe on this promotion, and your name is forever > suppressed from any communication from us until you choose to > activate it again (or ask us to do it for you). > > If you change your mind and can no longer attend the rally, just > return to the registration page, fill out the form again using the > same e-mail address, and put " 0 " as the number of people attending. > > The Park requires us to give an accurate estimate 45 days prior. > That's April 11th. If we underestimate, we will be penalized. If we > overestimate, we will be overcharged. There are many decisions that > flow from this estimate including security planning and porta potty > rentals. Please help us give the Park our best estimate for the > number of people who will be there. > > And please know, above all, we'd rather pay a penalty than not have > you go!! > > So sign up when you can! One thing's for sure, if you don't plan to > go, it probably won't happen. Start planning now. > > VOLUNTEER! > > We're staffing our volunteer teams right now and we need YOU. Click > HERE, review the list and pick the one that's the best match for > your skills and interest. Set up, clean up, self-marshalls, local > carpooling, rally gear sales, handouts, petition clipboards, music, > social networking, community outreach, signage, satellite rally > organizers, and more... > > If you are worried about over-committing, please don't let that hold > you back. If everyone does a little bit, we will pull this off in > grand style. > > WHAT ELSE YOU CAN DO NOW > > Pledge your support! We expect to have our 501c3 application > officially submitted inside the next two weeks and then we'll ask > you to fulfill your promise to us. Making a pledge now gives us an > idea how many of you are on board. It also helps us to plan. > > Suggest participating organizations! Participating groups will be > able to distribute informational materials. Contact us if you're > interested! > > Read our article 2010: The Year of Advocacy from the April issue of > Autism File magazine. > > Tell everyone you know about the rally. E-mail the flyer, action > alerts, and article far and wide. Post on Facebook and Twitter. > > Make your travel plans! We just added another great hotel deal > through the long weekend. Airfares are still low. Chicago is > beautiful in the spring and there's lots to do. > > Organize a satellite rally! If you can't make it to Chicago but you > can get a group together to watch the rally and make some noise, let > us know. Since we'll be webcasting live, it'll be easy for groups to > rally with us real time. Get enough people together and it becomes a > media-worthy event. > > DO YOU HAVE ACCESS TO... ? > > Stage, sound and podium equipment. > > Walkie-talkies. > > Banners and signs. If you have a local business and can help rally- > goers design and make banners and signage, let us know! > > Low-cost color and black/white photocopying. > > Free/low-cost DJ for our post-rally party. > > Professional PR and media connections in the Chicagoland area. > > Let us know! > > LET'S ROLL > > We're counting on you... > > Louise Kuo Habakus > Holland > Bob Krakow > Mia Nitchun > Ginger ... > > and a growing list of volunteers and supporters > > Love, Gabby. :0) > http://stemcellforautism.blogspot.com/ > http://www.facebook.com/gabby911 > http://twitter.com/stemcell4autism > >  > " I know of nobody who is purely Autistic or purely neurotypical. > Even God had some Autistic moments, which is why the planets all > spin. " ~ Jerry Newport  > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 12. > Nephritis > Posted by: " keda " kddervishi@...  kddervishi > Sun Mar 28, 2010 3:57 pm (PDT) > > > Hello all, > > If someone knows what is the best treatment to treat nephritis to kids > please reply asap. I can't thank you enough. > we are seeing blood in her urine. > > Please share your knowledge and that will be great appreciated. > > Thanks to all > Keda > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 13a. > PANDAS AND Clostridia > Posted by: " " @...  > Sun Mar 28, 2010 4:25 pm (PDT) > > > Hi there. > > Our next DAN appt. is this coming weekend. My son has OCD (PANDAS??) > that I would like our doctor to address, he's always had OCD (for as > long as I can remember.) He had his titers check, I'm aware it > depends on the timing of the test, etc., to tell whether or not he > has it. But the test came back " within range. " > > I also suspect that he has Clostridia (he has green poop), what > other symptoms would there be for Clostridia?!? > > Is the treatment for PANDAS and Clostridia the same?!? I've tried to > research this and cannot find the answer. Is there a particular > antibiotic that is better for one and not the other? Can I find one > antibiotic to treat both problems, or are they the same? Again, I'm > confused about this one. Please help. > > My son has been on Diflucan for one month, btw. (doing great w/ it.) > > And we've been full force biomed for 18mos. (diet, supplements etc., > -- just to give you a little info. about us > > Thanks! > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (2) > 13b. > Re: PANDAS AND Clostridia > Posted by: " Virginia " virginiasmith@...  virginiasmith@... > m > Sun Mar 28, 2010 5:32 pm (PDT) > > > I heard at the Autism One conference that S boulardii is the best > treatment for Clostridia. > > We have used it with good results. > > Ginger > > question about probiotics > > When is the best time to give them? Empty stomach? How many billion > CFU's daily? > > Thank you! > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (3) > > RECENT ACTIVITY > 15 > New Members > Visit Your Group > Sell Online > Start selling with > our award-winning > e-commerce tools. > > Yahoo! Groups > Mental Health Zone > Learn about issues > Find support > > Find helpful tips > for Moderators > on the Yahoo! > Groups team blog. > > Need to Reply? > Click one of the " Reply " links to respond to a specific message in > the Daily Digest. > Create New Topic | Visit Your Group on the Web > Messages | Files | Photos | Database | Members | Calendar > > Change settings via the Web (Yahoo! ID required) > Change settings via email: Switch delivery to Individual | Switch > format to Traditional > Visit Your Group | Yahoo! Groups Terms of Use | Unsubscribe > 5 of 5 Photo(s) us.gif b.gif Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2010 Report Share Posted April 1, 2010 The Vanecko family is gone from March 27 to April 1 so they will not be able to respond until April 2. -The Vaneckos On Mar 28, 2010, at 9:02 PM, mb12 valtrex wrote: > Nasal Spray MB12, Antivirals, Stan Kurtz > Messages In This Digest (25 Messages) > 1.1. > Re: for those with recovered kids or nearly recovered... From: > chatting_cells > 1.2. > Re: for those with recovered kids or nearly recovered... From: > 2a. > Re: Teeth Grinding? From: kcboone > 2b. > Re: Teeth Grinding? From: SHARON SMITH > 2c. > Re: Teeth Grinding? From: dbklein34@... > 2d. > Re: Teeth Grinding? From: nancy cook > 2e. > Re: Teeth Grinding? From: dbklein34@... > 2f. > Re: Teeth Grinding? From: nancy cook > 2g. > Re: Teeth Grinding? From: dbklein34@... > 2h. > Re: Teeth Grinding? From: nancy cook > 3.1. > Re: Dr. Moulden From: Sloan > 4. > How much Brainchild OLE to give ? From: Jo > 5. > A question for Goddin From: Oriana > 6a. > Re: B12 test high From: Dennis and Beth > 7a. > Re: Gut Pain Cause? From: > 8a. > Re: question about newborn acne From: Cheryl Lowrance > 9a. > Re: question about growth and dietary issues From: Cheryl Lowrance > 10. > Molecular Diseases From: a DeVelbiss > 11. > Vaccination Is A Rights Issue! From: a DeVelbiss > 12. > Nephritis From: keda > 13a. > PANDAS AND Clostridia From: > 13b. > Re: PANDAS AND Clostridia From: Virginia > 14a. > question about probiotics From: > 14b. > Re: question about probiotics From: vel_villalobos@... > 14c. > Re: question about probiotics From: vel_villalobos@... > View All Topics | Create New Topic > Messages > 1.1. > Re: for those with recovered kids or nearly recovered... > Posted by: " chatting_cells " chatting_cells@...  > chatting_cells > Sun Mar 28, 2010 1:57 am (PDT) > > > Hi , > > I'm very happy for you after reading your post about what you did > for your son and your brother.....they are so blessed to have you in > their lives :-) > > Parden my ignorance...could you tell me what OoO is ? > > Thanks ! > > > > > Do all kids who have yeast, parasites, viral infiltration have a > hard time gaining weight or growing? I am just curious because my > daughter shows signs of the yeast issues as described by many of you > all, but she's not had a problem gaining weight since she was one > years old... she has always been like 75% for height, 50% for weight > (once we got over that initial weight gain issue when she was a tiny > baby) > > > > -- > > Toni > > > > ------ > > Mind like a steel trap... > > Rusty and illegal in 37 states. > > > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (2) > 10. > Molecular Diseases > Posted by: " a DeVelbiss " gabrieladevelbiss@...  > gabrieladevelbiss > Sun Mar 28, 2010 2:49 pm (PDT) > > >  > > Molecular Diseases >  >   > > STAR SCIENCE By A. Padlan, PhD and Gisela P. Padilla-Concep... > >  (The Philippine Star) Updated March 04, 2010 > > Sixty years ago, Linus ing, in a landmark paper published in > Science with several colleagues, proposed the concept of molecular > disease. The idea that a disease may be caused by a defect in a > molecule was a departure from common belief at that time. ing > specifically focused on sickle-cell anemia, in which red blood cells > became deformed from the normal disk-shape to a sickle-like shape > (thus the name) and became stiff (no longer pliable) so that they > could no longer easily squeeze through narrow blood vessels > (capillaries and venules). The resulting blockages caused > inflammations, severe pain, infections, organ damage, and early > death. ing proposed that the disease was caused by a defect in > the hemoglobin molecule. >  > Experiments showed that sickle-cell hemoglobin, under the influence > of an electric field, moved at a speed different from normal > hemoglobin, indicating that indeed there was a difference between > the two. Subsequent sequence analysis then showed that the beta > chain of sickle-cell hemoglobin differs from the beta chain of > normal hemoglobin at position 6, where sickle-cell hemoglobin has > the amino acid valine, while normal hemoglobin has glutamic acid. > (The hemoglobin in red blood cells is made up of four chains > identical in pairs: two alpha chains and two beta chains.) There > were no other differences. >  > It was also observed that sickle-cell hemoglobin formed long bundles > of fibers, or rods — but only when the molecule is deoxygenated. > (The hemoglobin in blood binds oxygen reversibly and functions as an > oxygen transporter. It picks up oxygen from the lungs > > (becomes oxygenated) and delivers the oxygen to the tissues (becomes > deoxygenated) .) It is those rods which cause the deformation and > stiffening of the red blood cells. Three-dimensional structure > analysis of deoxygenated sickle-cell hemoglobin by Warner Love's > group at s Hopkins revealed that the valine at position 6 > fortuitously fits in a hydrophobic pocket of a nearby molecule and > this (unfortunate) situation caused the formation of the rods. The > glutamic acid in normal hemoglobin, being charged, would not bind in > the pocket. Further, the binding could occur only when the > molecule is deoxygenated. (The hemoglobin molecule changes shape > when going from the oxygenated to the deoxygenated state.) Sickle- > cell anemia was clearly a molecular disease. >  > > Since then, many more diseases have been found to have a molecular > cause and a molecular disease became known as one in which the > pathogenesis (how the disease comes about and manifests itself) can > be traced to a single critical molecule, usually a protein. The > protein is either produced defectively (like hemoglobin in sickle- > cell anemia), not produced at all, or produced in abnormal (reduced > or elevated) amounts. There is a disease called alpha Thalassemia > major which affects mostly Southeast Asians, Chinese and Filipinos. > It is severe and results in death before or soon after birth. It is > caused by the complete absence of the gene that produces the alpha > chain of hemoglobin. > The ultimate cause of molecular disease is genetic — faulty > genes, and the fault could be simply a single nucleotide variation > from the normal. The fault could be a mutation in the gene that > codes for the particular protein, as in sickle-cell anemia, or it > could be the complete absence of the gene itself, as in alpha > Thalassemia major. The fault could be in the gene that controls the > expression of a particular protein, or in the gene for a protein > that modulates the activity of that protein. The defect could be in > only one copy of a gene (we inherit two copies — one from our > mother, one from our father), or in both copies. Or the disease > could be caused by an unusual number (e.g., duplication) of a > particular gene, or chromosome. Defects in the genes that control a > protein's expression or activity result in abnormal amounts of the > active protein. >  > For example, a type of severe combined immunodeficiency (SCID) has > been found to be caused by a defective enzyme, adenosine > deaminase. The result of this defect is the inadequate production > of lymphocytes that are crucial elements in our immune system. Thus, > individuals suffering from SCID are unable to fight infections and > have to live in sterile environments, e.g. bubbles, to remain alive. >  > Another example is Hunter syndrome, which results from the absence > or inadequate production of a crucial enzyme, iduronate-2- > sulfatase. The gene responsible for the disease is found in the X > chromosome. Females, who have two copies of the X chromosome, will > not be affected if the defect occurs in only one of the chromosomes. > Males, who have only one copy of the X chromosome, are not so lucky. >  > In our country, geneticists at the Institute of Human Genetics in UP > Manila are studying the occurrence of Thalassemias and sickle-cell > anemia in the Philippine population. Also at UP Manila, a newborn > (babies) screening center to test for treatable genetic diseases has > been operating for many years. There are tests for endocrinologic > (hormone-related) and metabolic (carbohydrate and amino acid) > disorders or inborn errors. By the Newborn Screening Program Act of > 2004 (Republic Act 9288), this service has been available to a > network of hospitals, lying-ins, and Rural Health Units and Health > Centers (RHUHCs) nationwide with cooperation from the DOH. >  > How can testing newborns help? Take for example, phenylketonuria > (PKU), an inborn error of amino acid metabolism. If a baby has a > genetic disorder that leads to low levels of phenyl hydroxylase, the > enzyme that converts the amino acid phenylalanine to the amino acid > tyrosine, a diet low in phenylalanine and high in tyrosine will > solve the problem. If the diet is not adjusted early, phenylalanine > from a normal diet accumulates and is converted to phenyl pyruvate > (a phenyl ketone, thus the name phenylketonuria) , which causes > problems with brain development, and leads to progressive mental > retardation and seizures. >  > Are cancer, diabetes, and cardiovascular disease (CVD) molecular > diseases? Yes, they are too, in a fundamental and general sense. But > they involve defects in more than one critical molecule. Cancer is > considered a polygenic disease (with mutations occurring > progressively in many genes and proteins); increased risk for > diabetes type 2 and CVD is associated with " metabolic > syndrome " (with defects involving several interrelated metabolic > pathways), and all three are considered complex diseases [complex, > meaning with many defects, as opposed to one defect (the original or > strict definition of a molecular disease)]. > Are molecular diseases always inherited from the genes of either one > of our parents? Based on the new wider definition of molecular > diseases — no, some mutations can be acquired in one's lifetime. > We live in an environment that can cause mutations to our genes > through the air and sunlight, our food and drink, and through > certain stressful physiologic conditions in our body. Some mutations > are inherited, while some are sporadically acquired. >  > In some cases, the genetic defect does not immediately cause > disease, but leads to the propensity for disease. An example is the > susceptibility to cancer that has been traced to a defect in p53, a > tumor suppressor protein. (p53 binds to DNA and this results in the > production of a protein that is involved in the suppression of cell > growth. A mutation in p53, that causes it to no longer bind DNA > effectively, results in uncontrolled cell growth and to tumor > formation.) Mutation s in other tumor suppressor genes, like the > BRCA1 (breast cancer 1) and BRCA2 genes, have been correlated with > higher incidence of cancer. Is the mutation found in a tumor mass > inherited or sporadic? One can easily find out. If the mutation is > found only in the tumor cells and not in the person's normal cells, > it is a sporadic one. >  > Even some personality disorders appear to have a genetic cause. For > example, there is a recent report that the tendency toward pair- > bonding, or monogamy, seems to be associated with the number of > copies of a particular gene variant (allele) that a person has. > Surprisingly (maybe not), the association is found only in males. > Men with two copies of the allele are more likely not to form long- > term bonds with their partners. > In reality, all diseases are molecular. Effective treatments > > require molecular medicine, and disease prevention and diagnosis > require molecular analysis. Nowadays, medical doctors and biomedical > scientists are focused on the understanding of the molecular basis > of diseases. It all goes back to Linus ing, that most intuitive, > quintessential molecular scientist, one of the greatest scientific > minds of our time, who first pointed out molecular diseases. He also > said that " man is simply a collection of molecules " and " can be > understood in terms of molecules. " >  > > * * * > A. Padlan is a corresponding member of the NAST and is an > adjunct professor in the UP Marine Science Institute. He can be > reached at epadlanupmsi (DOT) ph. >  > Gisela P. Padilla-Concepcion is a member of the NAST and is a > professor in the UP Marine Science Institute and chairs the Dean's > Office on Special Initiatives for the Advancement of the Sciences, > College of Science, UP Diliman. She can be reached at gpconcepcion@ > gmail.com. > > Love, Gabby. :0) > http://stemcellforautism.blogspot.com/ > http://www.facebook.com/gabby911 > http://twitter.com/stemcell4autism > >  > " I know of nobody who is purely Autistic or purely neurotypical. > Even God had some Autistic moments, which is why the planets all > spin. " ~ Jerry Newport  > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 11. > Vaccination Is A Rights Issue! > Posted by: " a DeVelbiss " gabrieladevelbiss@...  > gabrieladevelbiss > Sun Mar 28, 2010 3:13 pm (PDT) > > > > > If you're new to the list and wondering what this is all about, > please take a moment to read before erasing the note. We are > organizing a big national rally in Grant Park, downtown Chicago, on > May 26, 2010. > > And the reason is simple. > > Americans are very concerned about increased government compulsion > to vaccinate as a requirement for daycare, school and employment. > > Here's what you need to understand. > > You're being asked to fight the old war! And the argument is fear- > based... if you stop vaccinating, deadly diseases will return. We're > told, just get your damn vaccines. > > Government has no answers about fighting today's war. America has > the infant and maternal mortality rates of a Third World country. We > rank 45th in life expectancy. Our children: 10% with asthma, 4% food > allergies, 3-5% birth defects, 1% autism. Look around and what do > you see? ADD, peanut anaphylaxis, diabetes, eczema, seizures, OCD, > speech delays. Adults are no better off, chronically ill, fed a > steady diet of prescription meds. Half of all men, one-third of > women today will get cancer in their lifetime. > > Vaccine risks are known and documented. Some are killed or injured > by vaccines. Pick a shot and take a peek: package inserts and VAERS. > > There is no informed consent for vaccines. > > Vaccine makers have exceptionally strong liability protections. We > have removed their incentive to make safer shots. We have increased > their incentive to make more shots. And they have. > > If you're injured, you're on your own. Check out what the PREP Act > did for H1N1 swine flu vaccine manufacturers. > > Whether you start with the U.S. Constitution, the Universal > Declaration of Human Rights, or customary international law, people > understand what it means to be free. It means we have the right to > make the important decisions that affect our lives and those of our > children. This includes where we worship and the autonomy to control > and safeguard our own bodies. > > Vaccination is a rights issue. > > REGISTER!!! > > Two months and counting! > > If you are going to the rally, we need you to register right now. > Please!! Click this link or go to the rally website and sign up. > > Rest assured that we will not give your name to anyone else, for any > reason. > > And it is very easy to remove yourself from the list. If you are > getting this action alert now, you are already on our big list. By > registering, you will go into the Rally " bucket " so we can count you > for planning purposes. > > If you change your mind and no longer want to be on the big list, it > is very easy. Just scroll down to the bottom of this newsletter, > click Unsubscribe on this promotion, and your name is forever > suppressed from any communication from us until you choose to > activate it again (or ask us to do it for you). > > If you change your mind and can no longer attend the rally, just > return to the registration page, fill out the form again using the > same e-mail address, and put " 0 " as the number of people attending. > > The Park requires us to give an accurate estimate 45 days prior. > That's April 11th. If we underestimate, we will be penalized. If we > overestimate, we will be overcharged. There are many decisions that > flow from this estimate including security planning and porta potty > rentals. Please help us give the Park our best estimate for the > number of people who will be there. > > And please know, above all, we'd rather pay a penalty than not have > you go!! > > So sign up when you can! One thing's for sure, if you don't plan to > go, it probably won't happen. Start planning now. > > VOLUNTEER! > > We're staffing our volunteer teams right now and we need YOU. Click > HERE, review the list and pick the one that's the best match for > your skills and interest. Set up, clean up, self-marshalls, local > carpooling, rally gear sales, handouts, petition clipboards, music, > social networking, community outreach, signage, satellite rally > organizers, and more... > > If you are worried about over-committing, please don't let that hold > you back. If everyone does a little bit, we will pull this off in > grand style. > > WHAT ELSE YOU CAN DO NOW > > Pledge your support! We expect to have our 501c3 application > officially submitted inside the next two weeks and then we'll ask > you to fulfill your promise to us. Making a pledge now gives us an > idea how many of you are on board. It also helps us to plan. > > Suggest participating organizations! Participating groups will be > able to distribute informational materials. Contact us if you're > interested! > > Read our article 2010: The Year of Advocacy from the April issue of > Autism File magazine. > > Tell everyone you know about the rally. E-mail the flyer, action > alerts, and article far and wide. Post on Facebook and Twitter. > > Make your travel plans! We just added another great hotel deal > through the long weekend. Airfares are still low. Chicago is > beautiful in the spring and there's lots to do. > > Organize a satellite rally! If you can't make it to Chicago but you > can get a group together to watch the rally and make some noise, let > us know. Since we'll be webcasting live, it'll be easy for groups to > rally with us real time. Get enough people together and it becomes a > media-worthy event. > > DO YOU HAVE ACCESS TO... ? > > Stage, sound and podium equipment. > > Walkie-talkies. > > Banners and signs. If you have a local business and can help rally- > goers design and make banners and signage, let us know! > > Low-cost color and black/white photocopying. > > Free/low-cost DJ for our post-rally party. > > Professional PR and media connections in the Chicagoland area. > > Let us know! > > LET'S ROLL > > We're counting on you... > > Louise Kuo Habakus > Holland > Bob Krakow > Mia Nitchun > Ginger ... > > and a growing list of volunteers and supporters > > Love, Gabby. :0) > http://stemcellforautism.blogspot.com/ > http://www.facebook.com/gabby911 > http://twitter.com/stemcell4autism > >  > " I know of nobody who is purely Autistic or purely neurotypical. > Even God had some Autistic moments, which is why the planets all > spin. " ~ Jerry Newport  > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 12. > Nephritis > Posted by: " keda " kddervishi@...  kddervishi > Sun Mar 28, 2010 3:57 pm (PDT) > > > Hello all, > > If someone knows what is the best treatment to treat nephritis to kids > please reply asap. I can't thank you enough. > we are seeing blood in her urine. > > Please share your knowledge and that will be great appreciated. > > Thanks to all > Keda > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (1) > 13a. > PANDAS AND Clostridia > Posted by: " " @...  > Sun Mar 28, 2010 4:25 pm (PDT) > > > Hi there. > > Our next DAN appt. is this coming weekend. My son has OCD (PANDAS??) > that I would like our doctor to address, he's always had OCD (for as > long as I can remember.) He had his titers check, I'm aware it > depends on the timing of the test, etc., to tell whether or not he > has it. But the test came back " within range. " > > I also suspect that he has Clostridia (he has green poop), what > other symptoms would there be for Clostridia?!? > > Is the treatment for PANDAS and Clostridia the same?!? I've tried to > research this and cannot find the answer. Is there a particular > antibiotic that is better for one and not the other? Can I find one > antibiotic to treat both problems, or are they the same? Again, I'm > confused about this one. Please help. > > My son has been on Diflucan for one month, btw. (doing great w/ it.) > > And we've been full force biomed for 18mos. (diet, supplements etc., > -- just to give you a little info. about us > > Thanks! > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (2) > 13b. > Re: PANDAS AND Clostridia > Posted by: " Virginia " virginiasmith@...  virginiasmith@... > m > Sun Mar 28, 2010 5:32 pm (PDT) > > > I heard at the Autism One conference that S boulardii is the best > treatment for Clostridia. > > We have used it with good results. > > Ginger > > question about probiotics > > When is the best time to give them? Empty stomach? How many billion > CFU's daily? > > Thank you! > > Back to top > Reply to sender | Reply to group | Reply via web post > Messages in this topic (3) > > RECENT ACTIVITY > 15 > New Members > Visit Your Group > Sell Online > Start selling with > our award-winning > e-commerce tools. > > Yahoo! Groups > Mental Health Zone > Learn about issues > Find support > > Find helpful tips > for Moderators > on the Yahoo! > Groups team blog. > > Need to Reply? > Click one of the " Reply " links to respond to a specific message in > the Daily Digest. > Create New Topic | Visit Your Group on the Web > Messages | Files | Photos | Database | Members | Calendar > > Change settings via the Web (Yahoo! ID required) > Change settings via email: Switch delivery to Individual | Switch > format to Traditional > Visit Your Group | Yahoo! Groups Terms of Use | Unsubscribe > 5 of 5 Photo(s) us.gif b.gif Quote Link to comment Share on other sites More sharing options...
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