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Re: Darn Blood Pressure!

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Hi Teri!

We haven't heard from you in a while! Thanks for posting. I am sorry your

BP is hard to manage. I have found mine to be more problematic recently too. I

have been running 150/100 recently despite Cozaar, Lasix and Lopressor. I

think unfortunately that it does tend to get harder to manage as you lose renal

sufficiency. You are not in this boat alone!

Let us know what your doctor says on the 13th.

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Hi Teri.

Still mountain biking eh? Good for you. I wasn't able to ride my road bike

this past summer as much as before. I'm hoping that will change if I can

ever get a tranplant.

I had much the same problem as you with the blood pressure - pretty much

from around 1990 to almost the time I started dialysis. You don't even have

to have kidney disease. It seems to be in the nature of blood pressure

medications that for some, they work for a while and then gradually lose

their effectiveness. Me, well, no amount of any combination of meds worked

at all unless one was a diuretic.

Pierre

Darn Blood Pressure!

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been my

> biggest struggle with IGAN, being able to control my blood pressure

> with consistent medication (the same medicine over a long period of

> time). My current med combo is 160mg Diovan HCT and 10mg Norvasc.

> I've been on the Diovan for about 4 years now I think and it seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on meds "

> boat?

>

> Teri in Texas

>

>

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Hi Teri.

Still mountain biking eh? Good for you. I wasn't able to ride my road bike

this past summer as much as before. I'm hoping that will change if I can

ever get a tranplant.

I had much the same problem as you with the blood pressure - pretty much

from around 1990 to almost the time I started dialysis. You don't even have

to have kidney disease. It seems to be in the nature of blood pressure

medications that for some, they work for a while and then gradually lose

their effectiveness. Me, well, no amount of any combination of meds worked

at all unless one was a diuretic.

Pierre

Darn Blood Pressure!

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been my

> biggest struggle with IGAN, being able to control my blood pressure

> with consistent medication (the same medicine over a long period of

> time). My current med combo is 160mg Diovan HCT and 10mg Norvasc.

> I've been on the Diovan for about 4 years now I think and it seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on meds "

> boat?

>

> Teri in Texas

>

>

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Hi Teri,

I think you hit on the most recurrent (and serious) problems! This is one

I would completely defer to Pierre and others with more experience than

I.... however, from our limited (1.5 years) experience, it seems to be a

matter of perpetual vigilance and perpetual tweaking. 's current

combo is 15 mg lisinopril in the AM and PM, along with 10 mg Norvasc in the

AM and another 5 mg in the PM (a bit much for a 13 year old!). We are

currently on our third episode of trying to stay under control. It seems

that we spend 2-3 months getting meds adjusted, after which everything is

find for another 2-3 months ---- and then we start the whole cycle over

again!

Lest I seem alarmist, I should mention, that BP control for MPGN tends to be

more of an issue than for IgAN folks. However, it is a very serious issue

for everyone!

Cy

Darn Blood Pressure!

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been my

> biggest struggle with IGAN, being able to control my blood pressure

> with consistent medication (the same medicine over a long period of

> time). My current med combo is 160mg Diovan HCT and 10mg Norvasc.

> I've been on the Diovan for about 4 years now I think and it seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on meds "

> boat?

>

> Teri in Texas

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

>

> To unsubcribe via email,

> iga-nephropathy-unsubscribe

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

>

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Hi Teri,

I think you hit on the most recurrent (and serious) problems! This is one

I would completely defer to Pierre and others with more experience than

I.... however, from our limited (1.5 years) experience, it seems to be a

matter of perpetual vigilance and perpetual tweaking. 's current

combo is 15 mg lisinopril in the AM and PM, along with 10 mg Norvasc in the

AM and another 5 mg in the PM (a bit much for a 13 year old!). We are

currently on our third episode of trying to stay under control. It seems

that we spend 2-3 months getting meds adjusted, after which everything is

find for another 2-3 months ---- and then we start the whole cycle over

again!

Lest I seem alarmist, I should mention, that BP control for MPGN tends to be

more of an issue than for IgAN folks. However, it is a very serious issue

for everyone!

Cy

Darn Blood Pressure!

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been my

> biggest struggle with IGAN, being able to control my blood pressure

> with consistent medication (the same medicine over a long period of

> time). My current med combo is 160mg Diovan HCT and 10mg Norvasc.

> I've been on the Diovan for about 4 years now I think and it seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on meds "

> boat?

>

> Teri in Texas

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

>

> To unsubcribe via email,

> iga-nephropathy-unsubscribe

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

>

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The body has many different mechanisms or systems for raising blood

pressure. When it senses that more filtering is needed in the kidneys, it

uses them. Any drug you use, it can get around somehow. That's why many of

us end up taking an ACE inhibitor or an angiotensin II receptor blocker (to

partially block the renin-angiotensin system which the kidneys themselves

can control by simply secreting more renin), a calcium channel blocker (to

directly dilate the smooth muscle of the blood vessels), perhaps a beta

blocker to mainly slow down the heart rate and the pumping capacity of the

heart, a diuretic to remove more sodium and fluid, and if all that doesn't

work, the dreaded clonidine is trotted out. That one works mainly in the

brain. There are a number of lesser-used drugs also.

The minute you try to lower BP artificially, the body's systems for raising

BP get into high gear - but it does take them a little while to catch up. If

you block one, another takes over. In the end, nothing succeeds like taking

the sodium out or not putting it in (not that I'm suggesting anyone diet

without being advised by their doctor).

Pierre

Re: Darn Blood Pressure!

> Hi Teri,

>

> I think you hit on the most recurrent (and serious) problems! This is

one

> I would completely defer to Pierre and others with more experience than

> I.... however, from our limited (1.5 years) experience, it seems to be a

> matter of perpetual vigilance and perpetual tweaking. 's current

> combo is 15 mg lisinopril in the AM and PM, along with 10 mg Norvasc in

the

> AM and another 5 mg in the PM (a bit much for a 13 year old!). We are

> currently on our third episode of trying to stay under control. It

seems

> that we spend 2-3 months getting meds adjusted, after which everything is

> find for another 2-3 months ---- and then we start the whole cycle over

> again!

>

> Lest I seem alarmist, I should mention, that BP control for MPGN tends to

be

> more of an issue than for IgAN folks. However, it is a very serious issue

> for everyone!

>

> Cy

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Drugs like Diovan are thought to help lower proteinuria because, aside from

lowering the body's overall BP, they specifically lower intraglomerular BP -

lower BP in the glomeruli, less protein is pushed through the glomerular

walls. That's the theory, anyway. There may also be some healing properties

on the blood vessels that we don't yet understand, and the glomeruli are

just clumps of very tiny blood vessels. Because they lower the

intraglomerular BP, another consequence is that these drugs actually lower

your kidney function a little, but that's of no significance.

Pierre

Re: Darn Blood Pressure!

> Hi Teri,

> I too have had a time controlling my blood pressure. Over the past

10 years, I have had the exact same problem. My meds would work for awhile,

and then boom, up went the b/p. Try and Try again. My current b/p meds are

Diovan 160mg with HCTZ, and Toprol 50mg/d. My neph is trying to titrate up

to 320mg of Diovan due to the amount of protein I spill in the urine. I

don't quite understand it all, but the Diovan is supposed to help lessen the

amount of protein spilled. Anyway, Hang in there, but really be aggressive

on treatment. Must I remind everyone that at the age of 30 I had a stroke,

due to uncontrolled b/p. My prayers are with you.

>

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Hey Teri,

I have been taking 1 Tarka 2/180MG and 1 Cozaar 50MG just once a day

in the morning for 4 years without any problem.You may want to ask

your neph about these and see if they are right for you.Hope you

find something to help very soon.

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been

my

> biggest struggle with IGAN, being able to control my blood

pressure

> with consistent medication (the same medicine over a long period

of

> time). My current med combo is 160mg Diovan HCT and 10mg

Norvasc.

> I've been on the Diovan for about 4 years now I think and it

seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on

the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but

still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings

home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on

meds "

> boat?

>

> Teri in Texas

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Hi Teri,

I have been having problems with my bp meds this past year, and I

was just diagnosed in Mar 2002....I just keep hoping it's due to

stress (wedding) and illness (flu and colds).

I'm on 80 mg Diovan and salmon fish oil pills, so I'm always afraid

my neph will need to give me more aggresive treatments!

Sophia

> Anyone else have problems keeping their blood pressure down and

> staying on medications for more than a few years? That has been

my

> biggest struggle with IGAN, being able to control my blood

pressure

> with consistent medication (the same medicine over a long period

of

> time). My current med combo is 160mg Diovan HCT and 10mg

Norvasc.

> I've been on the Diovan for about 4 years now I think and it

seemed

> to do pretty well until the last few months. Now my BP is back up

> to 158/108 by the end of the day.....have to go back to neph on

the

> 13th to see what to do now.

>

> I mostly feel fine - I do feel fatigued most of the time, but

still

> lift weights and ride road and mountain bikes......but when I

> realize my BP will not stay controlled, it scares me and brings

home

> the fact that I really DO have a chronic kidney disease that could

> eventually take my kidneys......DARNIT!!!!! LOL

>

> Sigh - who all is in the " stupid high blood pressure while on

meds "

> boat?

>

> Teri in Texas

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I worry a little (now there's another stress!) about my job which is pretty

stressful and the impact on my BP

Re: Re: Darn Blood Pressure!

Hi Sophia,

Stress definitely has an impact on your blood pressure, and weddings count as

very high stress!

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