Guest guest Posted March 12, 2008 Report Share Posted March 12, 2008 Simple Test Predicts Type 1 Diabetes Researchers are developing a simple test which follows a new cellular pathway, that may predict whether a child will develop Type 1 diabetes. Professor Ranjeny and her colleagues from UQ's Diamantina Institute for Cancer, Immunology and Metabolic Medicine , have identified a cellular pathway known as NF-kappa B that is activated in blood cells of people with Type 1 diabetes. " Blood cells are the major infection and immune-control cells of the body, called monocytes and dendritic cells, " Professor said. " Monocytes from healthy people are 'quiet' in the blood and if we expose them to infection outside the body, the NF-kappa B pathway gets activated. " In individuals with Type 1 diabetes, we found monocyte NF-kappa B was already activated in the blood, and when exposed to infection the pathway shut down. This tells us something fundamental about the problems of immune control that cause diabetes to develop in children. " As a spin off, by simply taking blood, we hope to now be able to identify if a child will develop diabetes. Professor said Type 1 diabetes is caused by problems in the immune system, so that the pancreas is not tolerated - like an organ rejection. " In a similar way, people with rheumatoid arthritis don't tolerate their own joints, and they get inflamed, sore and swollen, " she said. " The pancreas of diabetics doesn't get sore but it gets inflamed, and then stops producing the hormone insulin. Insulin is needed to control blood sugar. " She said the test would target families with a history of diabetes with the aim of picking up other children at risk. " Currently available tests pick up this risk rather late and in relatively few people, when there is already evidence of intolerance of the pancreas. We are investigating at what stage our test becomes abnormal, " she said. " With various trials of vaccines for diabetes underway, the potential is there to identify and intervene in children at risk of Type 1 diabetes before it occurs. " But what is also important, is that we are in a position to really investigate why the immune system loses control before the disease starts. That fundamental understanding will bring the vaccines of the future. " Abnormal NF- {kappa} B Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes- J. Immunol., Mar 2008; 180: 3166 - 3175. Article Options Print Print Send to Friend Send to friend This article is part of the following Newsletter This article is also part of the following Category See Diabetes In Control latest newsletter visit our home page. Search Diabetes In Control table with 2 columns and 2 rows Article Title: Article Description: table end Search Browse our other news categories below. A. 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Professor Ranjeny and her colleagues from UQ's Diamantina Institute for Cancer, Immunology and Metabolic Medicine , have identified a cellular pathway known as NF-kappa B that is activated in blood cells of people with Type 1 diabetes. " Blood cells are the major infection and immune-control cells of the body, called monocytes and dendritic cells, " Professor said. " Monocytes from healthy people are 'quiet' in the blood and if we expose them to infection outside the body, the NF-kappa B pathway gets activated. " In individuals with Type 1 diabetes, we found monocyte NF-kappa B was already activated in the blood, and when exposed to infection the pathway shut down. This tells us something fundamental about the problems of immune control that cause diabetes to develop in children. " As a spin off, by simply taking blood, we hope to now be able to identify if a child will develop diabetes. Professor said Type 1 diabetes is caused by problems in the immune system, so that the pancreas is not tolerated - like an organ rejection. " In a similar way, people with rheumatoid arthritis don't tolerate their own joints, and they get inflamed, sore and swollen, " she said. " The pancreas of diabetics doesn't get sore but it gets inflamed, and then stops producing the hormone insulin. Insulin is needed to control blood sugar. " She said the test would target families with a history of diabetes with the aim of picking up other children at risk. " Currently available tests pick up this risk rather late and in relatively few people, when there is already evidence of intolerance of the pancreas. We are investigating at what stage our test becomes abnormal, " she said. " With various trials of vaccines for diabetes underway, the potential is there to identify and intervene in children at risk of Type 1 diabetes before it occurs. " But what is also important, is that we are in a position to really investigate why the immune system loses control before the disease starts. That fundamental understanding will bring the vaccines of the future. " Abnormal NF- {kappa} B Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes- J. Immunol., Mar 2008 ; 180: 3166 - 3175. See Diabetes In Control latest newsletter visit our Search Diabetes In Control Browse our other news categories below. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Special Offers http://www.diabetesincontrol.com/aserver/adclick.php?n=a929c42d Free Newsletter Not Subscribed? Get the FREE Diabetes In Control Newsletter today. Click Here / / / A1CNow+RT *Results in just 5 minutes. New reimbursement rates for the A1cNow+ Call for more information. Click Here To Learn More *No waiting for lab results. *CLIA-Waived. *Lab-accurate at 99%. Flash movie end Copyright @ 1999-2006 Diabetes In Control, Inc.. 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