Guest guest Posted October 8, 2003 Report Share Posted October 8, 2003 Hi , I couldn't get the abstract you were referring to (didn't make it past the PubMeds page). Can you give me the name of the first author and I'll do so stalking? It's always nice to have another person haunting the corridors of PubMeds. This isn't my area of expertise, but I'll speculate a little. Like MPGN, other proliferative kidney diseases (MPGN) are also idiopathic. For example, idiopath MPGN generally follows a common pattern (adolescent onset). However, it can also be caused by other viruses such as hep C, HIV and strep. My best guess is that the genes for an immune system defect unlying MPGN get turned on by adolescence or when responding to such viruses. In many cases, treatment of the underlying virus seems to be associated with stopping the progression of the MPGN. In other cases, treatment of the underlying virus has little effect on the MPGN which continues to progress (sorry to be so imprecise here, but MPGN is so rare that reproducable studies are close to nonexistent). I'm a little wary about leaping to the conclusion that it is caused by the virus, but rather the virus is associated with the " unmasking " as it were of the immune defect. I haven't seen anything that suggests anything different for IgAN Ultimately, with both MPGN and IgAN, I think we need to look at agents that turn off the defective gene or that inhibit the production of the proteins associated with it. However, this is mere speculation. I also made a huge fool of myself several years ago when I insisted that ulcers couldn't be caused by bacteria! There's this great web site that associates various diseases with different genes. I can't put my finger on it immediately, but I'll try to dig it up for you. Cy Re: Hepatitis B link > good grief I'm replying to my own posts, I'm losing it... > > I've been chewing the cud on this, now I get flare ups of IGAN when > I'm mega stressed/ run down etc, (akin to people getting cold sores, > but ever so slightly worse), some of us have grumbling constantly > detiorating IGAN, some of us have severe bouts of proteinurea type > IGAN, some of us spontaneously go into remission. The more I live > with this damn disease and research it, I'm gradually convincing > myself IGAN is a symptom of some other problem, as was recently > discovered for crohn's disease, I'd wager a ten pounds that some > virus is the problem (I don't gamble :-) hence my meager bet). > > > > > me, the web stalker, off again... > > > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > > cmd=Retrieve & db=PubMed & list_uids=12970894 & dopt=Abstract > > > > " CONCLUSION: There is a relationship between HBV infection and > IgAN " > > > > well, I've never seen a DEFINITE link in any paper before... > > > > mmmmmmmMMMMMMMMMMmmmmmmm > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2003 Report Share Posted October 9, 2003 , You're not losing it, I have similar thoughts and theories.......I heard a program, last week, on the BBC about Crohn's and ulcerative colitis and they have been doing lots of new studies in this area and have found that a lot of people who have got Crohn's (another autoimmune disease, as you know) have antibodies to the MAPS bug? They found antibodies in my blood for avium TB (Bird TB) and it was commented on by a Prof doing the tests that those antibodies floating around in my blood wouldn't help the way I feel. The point is though, that after having that horrendous bug I started to have kidney pains and infections etc etc. Sally UK Re: Hepatitis B link good grief I'm replying to my own posts, I'm losing it... I've been chewing the cud on this, now I get flare ups of IGAN when I'm mega stressed/ run down etc, (akin to people getting cold sores, but ever so slightly worse), some of us have grumbling constantly detiorating IGAN, some of us have severe bouts of proteinurea type IGAN, some of us spontaneously go into remission. The more I live with this damn disease and research it, I'm gradually convincing myself IGAN is a symptom of some other problem, as was recently discovered for crohn's disease, I'd wager a ten pounds that some virus is the problem (I don't gamble :-) hence my meager bet). > me, the web stalker, off again... > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > cmd=Retrieve & db=PubMed & list_uids=12970894 & dopt=Abstract > > " CONCLUSION: There is a relationship between HBV infection and IgAN " > > well, I've never seen a DEFINITE link in any paper before... > > mmmmmmmMMMMMMMMMMmmmmmmm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2003 Report Share Posted October 9, 2003 , You're not losing it, I have similar thoughts and theories.......I heard a program, last week, on the BBC about Crohn's and ulcerative colitis and they have been doing lots of new studies in this area and have found that a lot of people who have got Crohn's (another autoimmune disease, as you know) have antibodies to the MAPS bug? They found antibodies in my blood for avium TB (Bird TB) and it was commented on by a Prof doing the tests that those antibodies floating around in my blood wouldn't help the way I feel. The point is though, that after having that horrendous bug I started to have kidney pains and infections etc etc. Sally UK Re: Hepatitis B link good grief I'm replying to my own posts, I'm losing it... I've been chewing the cud on this, now I get flare ups of IGAN when I'm mega stressed/ run down etc, (akin to people getting cold sores, but ever so slightly worse), some of us have grumbling constantly detiorating IGAN, some of us have severe bouts of proteinurea type IGAN, some of us spontaneously go into remission. The more I live with this damn disease and research it, I'm gradually convincing myself IGAN is a symptom of some other problem, as was recently discovered for crohn's disease, I'd wager a ten pounds that some virus is the problem (I don't gamble :-) hence my meager bet). > me, the web stalker, off again... > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > cmd=Retrieve & db=PubMed & list_uids=12970894 & dopt=Abstract > > " CONCLUSION: There is a relationship between HBV infection and IgAN " > > well, I've never seen a DEFINITE link in any paper before... > > mmmmmmmMMMMMMMMMMmmmmmmm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2003 Report Share Posted October 9, 2003 the link was split by the editor:- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve & db=PubMed & list_uids=12970894 & dopt=Abstract full article:- http://www.wjgnet.com/1007-9327/9/2004.asp make sure you get it all on one line, no spaces... here's the header from the article:- ISSN 1007-9327 CN 14-1219/R World J Gastroenterol 2003 September;9 (9):2004-2008 Role of hepatitis B virus infection in pathogenesis of IgA nephropathy Nian-Song Wang, Zhao-Long Wu, Yue-E Zhang, Mu-Yi Guo, Lv-Tan Liao > Hi , > > I couldn't get the abstract you were referring to (didn't make it past the > PubMeds page). Can you give me the name of the first author and I'll do so > stalking? It's always nice to have another person haunting the corridors of > PubMeds. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2003 Report Share Posted October 9, 2003 Thanks a lot Jeff. I'm going to give this a serious read. However, it seems that one critical piece of info is missing from the article. The article states that " Among 100 patients with IgAN, HBs antigenemia was detected in 18 patients (18.00 %). " From my cursory read, the article fails to state what the Hep B infection rate is in that portion of the Chinese population. I would assume that the hep B infection rate is much higher than here as hep B vaccination is not universal. The argument would be a lot stronger if they showed that the hepititus rate is very low in the population at large. However, I want to go back and read this more closely, because I could be missing something. I appreciate getting full articles! It's good to know someone else out there is crawling the web on this stuff! Cy Re: Hepatitis B link > the link was split by the editor:- > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > cmd=Retrieve & db=PubMed & list_uids=12970894 & dopt=Abstract > > > full article:- > > http://www.wjgnet.com/1007-9327/9/2004.asp > > make sure you get it all on one line, no spaces... > > here's the header from the article:- > > ISSN 1007-9327 CN 14-1219/R World J Gastroenterol 2003 September;9 > (9):2004-2008 > Role of hepatitis B virus infection in pathogenesis of IgA nephropathy > > Nian-Song Wang, Zhao-Long Wu, Yue-E Zhang, Mu-Yi Guo, Lv-Tan Liao > > > > > > Hi , > > > > I couldn't get the abstract you were referring to (didn't make it > past the > > PubMeds page). Can you give me the name of the first author and > I'll do so > > stalking? It's always nice to have another person haunting the > corridors of > > PubMeds. > > > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > > Quote Link to comment Share on other sites More sharing options...
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