Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 It appears that they are the same thing: " A standard treatment for colorectal cancer known as the Saltz regimen – a combination of three drugs including irinotecan (CPT-11), 5-flurouracil (5-FU) and leucovorin (LV). " Many here have had good results with this, in the states CPT-11 is often replaced by Oxilaplatin. That's what my husband is on and he's had good results with significant tumor shrinkage good appetite etc.He is also 43 which may make some difference but as I said MANY here have seen success. All chemo regimens have potential side effects. Diarrhea can be one. The oncologist should give you a list of things to look for and when to call. But if you are looking for an opinion I'd say give it a try. If your Mom gets bad side effects then you can discuss other options but for now this seems the way to go. God Bless and let us know how things work out. Narice ****************************** Hi all: It seems like there is an awful lot of information passed back and forth in this group that is helpful.  SO, I'm hoping some of you can provide insight regarding a chemo choice.  My Mom was diagnosed with Stage 4 colon cancer, had surgery four weeks ago and had two sections of bowel removed, but the surgeon noticed considerable spread to the bladder, ureters, and abdominal wall, which he was unable to completely remove for fear of compromising the ureters. Onc. opinion was not to radiate cause area was too large and too close to healthy bowel. Now she has a choice between Saltz and FOLFIRI regimens of 5FU, irinotecan and leucovorin (hope I spelled those right). We live in Canada, so drug choices are more limited (eg. no access to Oxaliplatin except in some clinical trials that she is not a candidate for). I have read some alarming reports about the toxicity of the Saltz regimen and its potential to cause life threatening diarrhea. Would this be a reason to choose FOLFIRI instead, or does it have exactly the same complications? Has anyone had to look in to this? Any insight or experience you can offer would be much appreciated. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 I live in Canada too and I was of the impression that Oxaloplatin is available here. I'll have to check that further. If not, then the triplet of CPT11/5FU/LV would hopefully help her. Barry > It appears that they are the same thing: > > " A standard treatment for colorectal cancer known as the Saltz regimen †" a > combination of three drugs including irinotecan (CPT-11), 5- flurouracil (5-FU) > and leucovorin (LV). " > > Many here have had good results with this, in the states CPT-11 is often > replaced by Oxilaplatin. That's what my husband is on and he's had good results > with significant tumor shrinkage good appetite etc.He is also 43 which may make > some difference but as I said MANY here have seen success. > > All chemo regimens have potential side effects. Diarrhea can be one. The > oncologist should give you a list of things to look for and when to call. > But if you are looking for an opinion I'd say give it a try. If your Mom gets > bad side effects then you can discuss other options but for now this seems > the way to go. > God Bless and let us know how things work out. > Narice > > ****************************** > Hi all: > > It seems like there is an awful lot of information passed back and > forth in this group that is helpful.  SO, I'm hoping some of you can > provide insight regarding a chemo choice.  My Mom was diagnosed with > Stage 4 colon cancer, had surgery four weeks ago and had two sections > of bowel removed, but the surgeon noticed considerable spread to the > bladder, ureters, and abdominal wall, which he was unable to > completely remove for fear of compromising the ureters. Onc. opinion > was not to radiate cause area was too large and too close to healthy > bowel. > > Now she has a choice between Saltz and FOLFIRI regimens of 5FU, > irinotecan and leucovorin (hope I spelled those right). We live in > Canada, so drug choices are more limited (eg. no access to > Oxaliplatin except in some clinical trials that she is not a > candidate for). > > I have read some alarming reports about the toxicity of the Saltz > regimen and its potential to cause life threatening diarrhea. Would > this be a reason to choose FOLFIRI instead, or does it have exactly > the same complications? > > Has anyone had to look in to this? Any insight or experience you can > offer would be much appreciated. > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 I was under the impression that oxaliplatin IS available in Canada. > > It appears that they are the same thing: > > > > " A standard treatment for colorectal cancer known as the Saltz > regimen †" a > > combination of three drugs including irinotecan (CPT-11), 5- > flurouracil (5-FU) > > and leucovorin (LV). " > > > > Many here have had good results with this, in the states CPT-11 is > often > > replaced by Oxilaplatin. That's what my husband is on and he's had > good results > > with significant tumor shrinkage good appetite etc.He is also 43 > which may make > > some difference but as I said MANY here have seen success. > > > > All chemo regimens have potential side effects. Diarrhea can be > one. The > > oncologist should give you a list of things to look for and when > to call. > > But if you are looking for an opinion I'd say give it a try. If > your Mom gets > > bad side effects then you can discuss other options but for now > this seems > > the way to go. > > God Bless and let us know how things work out. > > Narice > > > > ****************************** > > Hi all: > > > > It seems like there is an awful lot of information passed back and > > forth in this group that is helpful.  SO, I'm hoping some of you > can > > provide insight regarding a chemo choice.  My Mom was diagnosed > with > > Stage 4 colon cancer, had surgery four weeks ago and had two > sections > > of bowel removed, but the surgeon noticed considerable spread to > the > > bladder, ureters, and abdominal wall, which he was unable to > > completely remove for fear of compromising the ureters. Onc. > opinion > > was not to radiate cause area was too large and too close to > healthy > > bowel. > > > > Now she has a choice between Saltz and FOLFIRI regimens of 5FU, > > irinotecan and leucovorin (hope I spelled those right). We live > in > > Canada, so drug choices are more limited (eg. no access to > > Oxaliplatin except in some clinical trials that she is not a > > candidate for). > > > > I have read some alarming reports about the toxicity of the Saltz > > regimen and its potential to cause life threatening diarrhea. > Would > > this be a reason to choose FOLFIRI instead, or does it have > exactly > > the same complications? > > > > Has anyone had to look in to this? Any insight or experience you > can > > offer would be much appreciated. > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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