Guest guest Posted January 13, 2004 Report Share Posted January 13, 2004 We can only sa that Nick is on a combo of Oxi/5FU/LV/+ Avastin. He has the infusion pack. First it was 22 hours,then 46,hous then 56 hours now 70 hours. Reason slower delivery caused much less reaction and he tolerated it better and we both got to sleep...His loose stools were few,his nausea much better and a lot less cramping. The cold effects last about 5 days after then he can have whatever in moderation. problem is we have a 21 day cycle. Still the avastin causes a flush the next day and that lasts about 26 hours then gradually goes away. He gets a slight rash,which lasts maybe 12 hours and a tingling in toes and fingers but it has not lasted. He gets tired much more easily but he will be 73 March 17th. All in all he has some hair thinning,no real loss,has to keep out of bright sun and his lips get very dry(he uses a moistureizer) and his counts are fairly good. take care Nick & Jane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2004 Report Share Posted January 13, 2004 My husband has a similar situation. He was diagnosed on 9/19/02 as Stage IV with extensive liver mets (he was 48 at the time). We have also gone through CPT-11/5FU/LV (good results for 6 months, then became resistant) ........... just completed about 6 months of Oxa/Xeloda (including increasing xeloda dosages to 5,000 mgs and adding 800 mgs of Celebrex) and have failed that. His CEA has been climbing and is close to 300 now. (Jumped from 194 to 292 in 8 days!) So ...... since we are waiting to try Erbitux/CPT-11 ......we are going to start Thursday on the Oxa/5FU(22-hour infusion)/LV combo. The hope is, of course, that somehow the slow infusion and Leucovorin might affect his tumors differently than the Xeloda did. It's worth a try. We aren't comfortable taking him off treatment completely and really don't want to incorporate the Camptosar into the mixture again until the Erbitux is available...... if we can hold off that long. Did your husband ever respond to either of those treatments? How many liver mets does he have and what size are they? Depending on the answers, he may have other options besides just chemo. :-) If you don't mind giving us a little more information, I'm sure we'll all try to share what we have learned and try to help you " shortcut " to some possible options. Best wishes to both of you and I hope he has a good response to the 24-hour infusion. Kindest Regards, Donna S. > Hello... > > My husband was dx on 02/14/03 with stage IV colon cancer with mets > to his liver. He is 43. He has tried the Oxiliplatin, Xeloda > combo, the 5FU,Campostar and Lecuvorin combo without success. His > recent CEA count was 307 and his liver spots are growing again. > > He is now on the 5FU 24 Hour Infusion. He is on a 4 week on, two > week off schedule. He gets his pack refilled every Monday. Can > someone give me any insight to this chemo treatment? > > Thanks! > > Baker's Wife Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2004 Report Share Posted January 13, 2004 Hi Baker's Wife: My husband just recently got a new oncologist who also put him on a pump for 5FU infusion over a period of 48 hours as with his old onc, he had severe, severe diarrhea side effects that didn't really hit until mid second cycle...and never really went away, even when the dosage was reduced. I was told by my husbands new onc that administering 5FU this way seems to be less toxic...considering the dose he got, he seemed to tolerate very well. New onc also put him on Leucavorin and Oxilaplatin...even though he was diagnosed stage III 7/03...but that could all have changed. We think the cancer is back. I'm posting in update. Please keep us posted on how this works for your husband. Fondly, Monika > Hello... > > My husband was dx on 02/14/03 with stage IV colon cancer with mets > to his liver. He is 43. He has tried the Oxiliplatin, Xeloda > combo, the 5FU,Campostar and Lecuvorin combo without success. His > recent CEA count was 307 and his liver spots are growing again. > > He is now on the 5FU 24 Hour Infusion. He is on a 4 week on, two > week off schedule. He gets his pack refilled every Monday. Can > someone give me any insight to this chemo treatment? > > Thanks! > > Baker's Wife Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2004 Report Share Posted January 14, 2004 <<New onc also put him on Leucavorin and Oxilaplatin...even though he was diagnosed stage III 7/03...but that could all have changed. We think the cancer is back.>> ****** Oh, Monika .............. I hope they're wrong!!! What makes them think it's back? I'll be praying extra hard that they are wrong on this one!!! {{{{hugs}}}} Donna S. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2004 Report Share Posted January 14, 2004 My husband has four tumors that they can see on a CAT scan, and 8 that they can see on a PET scan. I'm not sure of the size of all of them, but the last scan showed that one grew from 4cm to about 6 cm across. (I think that's what he said. I was very upset and didn't digest all of it.) We were told awhile back that surgery to remove these is not an option for us. The doctor told us that this is the last treatment option that we have available to us right now. He did say that there are some new drugs that may be released, but it may be 4-6 months before they do so. So we are praying that this treatment will do the trick. Baker's Wife > > Hello... > > > > My husband was dx on 02/14/03 with stage IV colon cancer with mets > > to his liver. He is 43. He has tried the Oxiliplatin, Xeloda > > combo, the 5FU,Campostar and Lecuvorin combo without success. His > > recent CEA count was 307 and his liver spots are growing again. > > > > He is now on the 5FU 24 Hour Infusion. He is on a 4 week on, two > > week off schedule. He gets his pack refilled every Monday. Can > > someone give me any insight to this chemo treatment? > > > > Thanks! > > > > Baker's Wife Quote Link to comment Share on other sites More sharing options...
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