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Hashish found to be good for joints

By Judy Siegel

JERUSALEM (June 7) - If your joints are going to pot, a hashish derivative may

be your salvation. A doctoral student at the Hebrew University's School of

Pharmacy in Jerusalem has discovered that a substance taken from the drug can be

effective as an anti-inflammatory drug for rheumatoid arthritis.

For her work with hashish as a therapeutic agent, na Tchilibon - a

32-year-old immigrant from Milan - has been named a winner of one of this year's

Kaye Prizes for Innovations and Inventions at the university. The prizes were

awarded during the 64th meeting of the university's board of governors, which

ended yesterday.

Tchilibon said that hashish (cannabis), which is derived from the Indian hemp

plant, has been used since ancient times for treating various ailments, such as

malaria, constipation, and rheumatic pains. The plant has both psychoactive and

non-psychoactive constituent elements.

She investigated the metabolism of the major non-psychoactive material in

cannabis, called cannabidiol (CBD), and found that an acid derived from CBD,

code named HU-320, is a potent anti-inflammatory agent. HU-320 is comparable to

the known drug indomethacin, but without the known and considerable

gastrointestinal side effects caused by that drug. Tchilibon added that use of

hashish or marijuana (another hemp plant derivative) has never been shown to

cause those side effects.

A patent based on her work has been registered via the university's Yissum

Research Development Company. Further evaluation is anticipated to test the

effectiveness of HU-320, particularly as a potential treatment for rheumatoid

arthritis.

Commenting on her decision to settle in Israel alone, without her family, five

years ago, Tchilibon said: " I wanted to study for my doctorate in medicinal

chemistry, and I felt that the Hebrew University was the best place to do this. "

Her research has been conducted in the pharmacy school's Department of Medicinal

Chemistry and Natural Products.

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